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FADS2 recombinant protein :: Fatty acid desaturase 2 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1090546
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $145 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $205 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $325 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $520 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $850 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fatty acid desaturase 2 (FADS2), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Fatty acid desaturase 2

 Product Synonym Names    Acyl-CoA 6-desaturase; Delta(6) fatty acid desaturase; D6D; Delta(6) desaturase; Delta-6 desaturase
 Product Gene Name   

FADS2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-131aa; Partial
 Sequence    MGKGGNQGEG AAEREVSVPT FSWEEIQKHN LRTDRWLVID RKVYNITKWS IQHPGGQRVI GHYAGEDATD AFRAFHPDLE FVGKFLKPLL IGELAPEEPS QDHGKNSKIT EDFRALRKTA EDMNLFKTNH V
 OMIM    606149
 3D Structure    ModBase 3D Structure for O95864
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of FADS2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for FADS2 recombinant protein

   Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It catalizes as well the introduction of a cis double bond in palmitate to produce the mono-unsaturated fatty acid sapienate, the most abundant fatty acid in sebum.
 Product Categories/Family for FADS2 recombinant protein    Cardiovascular
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 SDS-PAGE of FADS2 recombinant protein    FADS2 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for FADS2. It may not necessarily be applicable to this product.
 NCBI GI #    527498295
 NCBI GeneID    9415
 NCBI Accession #    NP_001268430.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001281501.1 [Other Products]
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 UniProt Primary Accession #    O95864 [Other Products]
 UniProt Secondary Accession #    Q6MZQ7; Q96H07; Q96SV8; Q9H3G3; Q9Y3X4; A8K2M6; B7Z634 [Other Products]
 UniProt Related Accession #    O95864 [Other Products]
 Molecular Weight    48,883 Da
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 NCBI Official Full Name    fatty acid desaturase 2 isoform 2
 NCBI Official Synonym Full Names    fatty acid desaturase 2
 NCBI Official Symbol    FADS2 [Similar Products]
 NCBI Official Synonym Symbols   
D6D; DES6; TU13; FADSD6; LLCDL2; SLL0262
[Similar Products]
 NCBI Protein Information    fatty acid desaturase 2
 UniProt Protein Name    Fatty acid desaturase 2
 UniProt Synonym Protein Names   
Acyl-CoA 6-desaturase; Delta(6) fatty acid desaturase; D6D; Delta(6) desaturase; Delta-6 desaturase
 Protein Family    Fatty acid desaturase
 UniProt Gene Name    FADS2 [Similar Products]
 UniProt Synonym Gene Names    D6D; Delta(6) desaturase; Delta-6 desaturase [Similar Products]
 UniProt Entry Name    FADS2_HUMAN
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 NCBI Summary for FADS2    The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
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 UniProt Comments for FADS2    FADS2: Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma- linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It catalizes as well the introduction of a cis double bond in palmitate to produce the mono-unsaturated fatty acid sapienate, the most abundant fatty acid in sebum. Belongs to the fatty acid desaturase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; EC 1.14.19.-; Lipid Metabolism - alpha-linolenic acid; Oxidoreductase; Lipid Metabolism - unsaturated fatty acid biosynthesis

Chromosomal Location of Human Ortholog: 11q12.2

Cellular Component: endoplasmic reticulum membrane; integral to plasma membrane; membrane

Molecular Function: linoleoyl-CoA desaturase activity; stearoyl-CoA 9-desaturase activity

Biological Process: linoleic acid metabolic process; unsaturated fatty acid biosynthetic process; unsaturated fatty acid metabolic process
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Product References and Citations for FADS2 recombinant protein

   "Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase." Cho H.P., Nakamura M.T., Clarke S.D. J. Biol. Chem. 274:471-477(1999)
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 Research Articles on FADS2    1. Data suggest that up-regulation of FADS2 (delta-6 fatty acid desaturase) and down-regulation of FADS1 (delta-5 fatty acid desaturase) in obesity leads to altered long-chain polyunsaturated fatty acid nutritional status. [META-ANALYSIS, REVIEW]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FADS2 recombinant proteinPathways associated with FADS2 recombinant protein
 Reference Product  PubMed Publications
 ELOVL5 recombinant protein  >29 publications with FADS2 and ELOVL5
 ELOVL2 recombinant protein  >22 publications with FADS2 and ELOVL2
 Products by Pathway  Pathway Diagram
 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate Biosynthesis (6-desaturase) Pathway antibodies  (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate Biosynthesis (6-desaturase) Pathway Diagram
 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate Biosynthesis II (4-desaturase) Pathway antibodies  (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate Biosynthesis II (4-desaturase) Pathway Diagram
 Biosynthesis Of Unsaturated Fatty Acids Pathway antibodies  Biosynthesis Of Unsaturated Fatty Acids Pathway Diagram
 Biosynthesis Of Unsaturated Fatty Acids Pathway antibodies  Biosynthesis Of Unsaturated Fatty Acids Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram
 Linoleic Acid (LA) Metabolism Pathway antibodies  Linoleic Acid (LA) Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
Diseases associated with FADS2 recombinant proteinOrgans/Tissues associated with FADS2 recombinant protein
 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >62 publications with FADS2 and Fatty Liver
 Cardiovascular Diseases Antibodies  >26 publications with FADS2 and Cardiovascular Diseases
 Inflammation Antibodies  >20 publications with FADS2 and Inflammation
 Liver Diseases Antibodies  >13 publications with FADS2 and Liver Diseases
 Atherosclerosis Antibodies  >7 publications with FADS2 and Atherosclerosis
 Carcinoma, Hepatocellular Antibodies  >5 publications with FADS2 and Carcinoma, Hepatocellular
 Weight Gain Antibodies  >5 publications with FADS2 and Weight Gain
 Nervous System Diseases Antibodies  >4 publications with FADS2 and Nervous System Diseases
 Disease Models, Animal Antibodies  >4 publications with FADS2 and Disease Models, Animal
 Liver Neoplasms Antibodies  >3 publications with FADS2 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >100 publications with FADS2 and Blood
 Liver Antibodies  >68 publications with FADS2 and Liver
 Brain Antibodies  >30 publications with FADS2 and Brain
 Heart Antibodies  >21 publications with FADS2 and Heart
 Muscle Antibodies  >19 publications with FADS2 and Muscle
 Adipose Tissue Antibodies  >18 publications with FADS2 and Adipose Tissue
 Skin Antibodies  >12 publications with FADS2 and Skin
 Connective Tissue Antibodies  >7 publications with FADS2 and Connective Tissue
 Vascular Antibodies  >6 publications with FADS2 and Vascular
 Lung Antibodies  >5 publications with FADS2 and Lung
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