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FCRL3 recombinant protein :: Fc receptor-like protein 3 (FCRL3) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1288578 FCRL3 recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $1,350 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,350 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,570 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,570 +1 FREE 8GB USB
1 mg (E-Coli)  /  $2,240 +2 FREE 8GB USB
0.1 mg (Baculovirus)  /  $2,240 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,705 +3 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,705 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fc receptor-like protein 3 (FCRL3), Recombinant Protein

 Also Known As   

Recombinant Human Fc receptor-like protein 3 (FCRL3), partial

 Product Gene Name   

FCRL3 recombinant protein

[Similar Products]
 Product Synonym Gene Name    FCRL3 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    18-573
 Sequence    GVA PKAVLLLNPP WSTAFKGEKV ALICSSISHS LAQGDTYWYH DEKLLKIKHD KIQITEPGNY QCKTRGSSLS DAVHVEFSPD WLILQALHPV FEGDNVILRC QGKDNKNTHQ KVYYKDGKQL PNSYNLEKIT VNSVSRDNSK YHCTAYRKFY ILDIEVTSKP LNIQVQELFL HPVLRASSST PIEGSPMTLT CETQLSPQRP DVQLQFSLFR DSQTLGLGWS RSPRLQIPAM WTEDSGSYWC EVETVTHSIK KRSLRSQIRV QRVPVSNVNL EIRPTGGQLI EGENMVLICS VAQGSGTVTF SWHKEGRVRS LGRKTQRSLL AELHVLTVKE SDAGRYYCAA DNVHSPILST WIRVTVRIPV SHPVLTFRAP RAHTVVGDLL ELHCESLRGS PPILYRFYHE DVTLGNSSAP SGGGASFNLS LTAEHSGNYS CDADNGLGAQ HSHGVSLRVT VPVSRPVLTL RAPGAQAVVG DLLELHCESL RGSFPILYWF YHEDDTLGNI SAHSGGGASF NLSLTTEHSG NYSCEADNGL GAQHSKVVTL NVTGTSRNRT GLT
 OMIM    180300
 3D Structure    ModBase 3D Structure for Q96P31
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Human
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of FCRL3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for FCRL3 recombinant protein

   This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus.
NCBI/Uniprot data below describe general gene information for FCRL3. It may not necessarily be applicable to this product.
 NCBI GI #    998614219
 NCBI GeneID    115352
 NCBI Accession #    NP_001307262.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001320333.1 [Other Products]
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 UniProt Primary Accession #    Q96P31 [Other Products]
 UniProt Secondary Accession #    Q5VXZ8; Q8N6S2; Q96LA4; Q96P27; Q96P28; Q96P29; Q96P30; A0N0M4; A8MTH7; D3DVD2 [Other Products]
 UniProt Related Accession #    Q96P31 [Other Products]
 Molecular Weight    77,921 Da
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 NCBI Official Full Name    Fc receptor-like protein 3 isoform 3
 NCBI Official Synonym Full Names    Fc receptor like 3
 NCBI Official Symbol    FCRL3 [Similar Products]
 NCBI Official Synonym Symbols   
FCRH3; IFGP3; IRTA3; SPAP2; CD307c
[Similar Products]
 NCBI Protein Information    Fc receptor-like protein 3
 UniProt Protein Name    Fc receptor-like protein 3
 UniProt Synonym Protein Names   
Fc receptor homolog 3Curated; FcRH3Curated; IFGP family protein 3; hIFGP3; Immune receptor translocation-associated protein 3; SH2 domain-containing phosphatase anchor protein 2; CD_antigen: CD307c
 Protein Family    Fc receptor-like protein
 UniProt Gene Name    FCRL3 [Similar Products]
 UniProt Synonym Gene Names    FcR-like protein 3Curated; FcRL3Curated; FcRH3Curated; hIFGP3 [Similar Products]
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 NCBI Summary for FCRL3    This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
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 UniProt Comments for FCRL3    Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells (PubMed:23857366). Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling (PubMed:19843936). Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells (PubMed:20190142, PubMed:19494275).
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 Research Articles on FCRL3    1. Pooled genome wide association study identified a genetic variant upstream of FCRL3 as a susceptibility locus for Graves' disease in addition to those identified in the Major Histo-compatibility Complex.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FCRL3 recombinant proteinPathways associated with FCRL3 recombinant protein
 Reference Product  PubMed Publications
 ZAP70 recombinant protein  >1 publications with FCRL3 and ZAP70
 Products by Pathway  Pathway Diagram
 T Cell Receptor Signaling Pathway antibodies  T Cell Receptor Signaling Pathway Diagram
Diseases associated with FCRL3 recombinant proteinOrgans/Tissues associated with FCRL3 recombinant protein
 Disease Name  Pubmed Publications
 Autoimmune Diseases Antibodies  >61 publications with FCRL3 and Autoimmune Diseases
 Thyroid Diseases Antibodies  >17 publications with FCRL3 and Thyroid Diseases
 Graves Disease Antibodies  >12 publications with FCRL3 and Graves Disease
 Eye Diseases Antibodies  >9 publications with FCRL3 and Eye Diseases
 Goiter Antibodies  >7 publications with FCRL3 and Goiter
 Hyperthyroidism Antibodies  >7 publications with FCRL3 and Hyperthyroidism
 Metabolic Diseases Antibodies  >6 publications with FCRL3 and Metabolic Diseases
 Thyroiditis Antibodies  >6 publications with FCRL3 and Thyroiditis
 Thyroiditis, Autoimmune Antibodies  >6 publications with FCRL3 and Thyroiditis, Autoimmune
 Digestive System Diseases Antibodies  >5 publications with FCRL3 and Digestive System Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >18 publications with FCRL3 and Blood
 Liver Antibodies  >2 publications with FCRL3 and Liver
 Bone Marrow Antibodies  >2 publications with FCRL3 and Bone Marrow
 Pharynx Antibodies  >1 publications with FCRL3 and Pharynx
 Eye Antibodies  >1 publications with FCRL3 and Eye
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