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FPN recombinant protein :: Ferroportin (FPN) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2012282 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $130 +1 FREE 8GB USB
0.05 mg  /  $225 +1 FREE 8GB USB
0.1 mg  /  $340 +1 FREE 8GB USB
0.2 mg  /  $415 +1 FREE 8GB USB
0.5 mg  /  $800 +1 FREE 8GB USB
1 mg  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ferroportin (FPN), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Ferroportin (FPN)

 Product Gene Name   

FPN recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2; NC_000002.11 (190425316..190448478, complement). Location: 2q32
 OMIM    604653
 3D Structure    ModBase 3D Structure for Q9NP59
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 Host    E Coli
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 Purity/Purification    > 80%
 Form/Format    20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300.
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 Source    Prokaryotic expression.
 Residues    Trp127~Val321 linked with LEHHHHHH
 Tags    Two N-terminal Tags, His-tag and GST-tag
  Tissue Specificity    Placenta, Spleen.
 Subcellular Location    Cell membrane; Multi-pass membrane protein.
 Traits    Freeze-dried powder
 Predicted isoelectric point    6.0
 Predicted Molecular Mass    52.8kDa
 Accurate Molecular Mass    52kDa as determined by SDS-PAGE reducing conditions.
 Usage    Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8 degree C for one month.
Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of FPN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for FPN recombinant protein   

SDS-PAGE, WB, ELISA, IP, CoIP, Purification, Amine Reactive Labeling.
(May be suitable for use in other assays to be determined by the end user.)

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 Sequence of FPN recombinant protein    FPN recombinant protein Sequence image
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 Gene Sequencing of FPN recombinant protein    FPN recombinant protein Gene Sequencing image
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 SDS-PAGE of FPN recombinant protein    FPN recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for FPN. It may not necessarily be applicable to this product.
 NCBI GI #    7657100
 NCBI GeneID    30061
 NCBI Accession #    NP_055400.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_014585.5 [Other Products]
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 UniProt Primary Accession #    Q9NP59 [Other Products]
 UniProt Secondary Accession #    Q6FI62; Q7Z4F8; Q8IVB2; Q9NRL0 [Other Products]
 UniProt Related Accession #    Q9NP59 [Other Products]
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 NCBI Official Full Name    solute carrier family 40 member 1
 NCBI Official Synonym Full Names    solute carrier family 40 (iron-regulated transporter), member 1
 NCBI Official Symbol    SLC40A1 [Similar Products]
 NCBI Official Synonym Symbols   
FPN1; HFE4; MTP1; IREG1; MST079; MSTP079; SLC11A3
[Similar Products]
 NCBI Protein Information    solute carrier family 40 member 1; iron regulated gene 1; putative ferroportin 1 variant IIIA; putative ferroportin 1 variant IIIB; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3
 UniProt Protein Name    Solute carrier family 40 member 1
 UniProt Synonym Protein Names   
Ferroportin-1; Iron-regulated transporter 1
 UniProt Gene Name    SLC40A1 [Similar Products]
 UniProt Synonym Gene Names    FPN1; IREG1; SLC11A3 [Similar Products]
 UniProt Entry Name    S40A1_HUMAN
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 NCBI Summary for FPN    The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]
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 UniProt Comments for FPN    SLC40A1: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4). HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevation of the transferrin saturation. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.

Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family

Chromosomal Location of Human Ortholog: 2q32

Cellular Component: multivesicular body; synaptic vesicle; basolateral plasma membrane; integral to plasma membrane; cytoplasm; integral to membrane; plasma membrane; intracellular

Molecular Function: iron ion transmembrane transporter activity; protein binding

Biological Process: anatomical structure morphogenesis; cellular iron ion homeostasis; positive regulation of transcription from RNA polymerase II promoter; transmembrane transport; lymphocyte homeostasis; negative regulation of apoptosis

Disease: Hemochromatosis, Type 4
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 Research Articles on FPN    1. A model is proposed that suggests that unlike proteases, which are irreversibly bound to activated alpha2M, hepcidin remains labile and available to down-regulate Fpn1.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FPN recombinant proteinPathways associated with FPN recombinant protein
 Reference Product  PubMed Publications
 HFE recombinant protein  >49 publications with FPN and HFE
 HAMP recombinant protein  >39 publications with FPN and HAMP
 TFR2 recombinant protein  >34 publications with FPN and TFR2
 HFE2 recombinant protein  >10 publications with FPN and HFE2
 SLC11A2 recombinant protein  >5 publications with FPN and SLC11A2
 HEPH recombinant protein  >1 publications with FPN and HEPH
 Products by Pathway  Pathway Diagram
 Iron Metabolism In Placenta Pathway antibodies  Iron Metabolism In Placenta Pathway Diagram
 Iron Uptake And Transport Pathway antibodies  Iron Uptake And Transport Pathway Diagram
 Metal Ion SLC Transporters Pathway antibodies  Metal Ion SLC Transporters Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway antibodies  Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway Diagram
Diseases associated with FPN recombinant proteinOrgans/Tissues associated with FPN recombinant protein
 Disease Name  Pubmed Publications
 Iron Overload Antibodies  >58 publications with FPN and Iron Overload
 Hemochromatosis Antibodies  >55 publications with FPN and Hemochromatosis
 Liver Diseases Antibodies  >15 publications with FPN and Liver Diseases
 Anemia Antibodies  >14 publications with FPN and Anemia
 Hemochromatosis, type 4 Antibodies  >12 publications with FPN and Hemochromatosis, type 4
 Inflammation Antibodies  >4 publications with FPN and Inflammation
 Neoplasms Antibodies  >4 publications with FPN and Neoplasms
 Fibrosis Antibodies  >3 publications with FPN and Fibrosis
 Breast Neoplasms Antibodies  >3 publications with FPN and Breast Neoplasms
 Brain Diseases Antibodies  >2 publications with FPN and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >41 publications with FPN and Blood
 Liver Antibodies  >33 publications with FPN and Liver
 Heart Antibodies  >6 publications with FPN and Heart
 Bone Antibodies  >6 publications with FPN and Bone
 Intestine Antibodies  >6 publications with FPN and Intestine
 Kidney Antibodies  >5 publications with FPN and Kidney
 Muscle Antibodies  >5 publications with FPN and Muscle
 Spleen Antibodies  >4 publications with FPN and Spleen
 Brain Antibodies  >4 publications with FPN and Brain
 Lung Antibodies  >3 publications with FPN and Lung
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