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FBN1 recombinant protein :: Fibrillin-1 (FBN1), partial Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS952913 FBN1 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $535 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $700 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $715 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $785 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $850 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $945 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,060 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,070 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,090 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,105 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,555 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,610 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,665 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,080 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fibrillin-1 (FBN1), partial, Recombinant Protein

 Also Known As   

Recombinant Bovine Fibrillin-1 (FBN1), partial

 Product Synonym Names    Fibrillin-1; MP340
 Product Gene Name   

FBN1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    2732-2871. Partial, provide the Asprosin chain
 Sequence    SANETDASNI EDQPEIEANV SLASWDVEKT AVFAFNISHI SNKVRILELL PALTTLTNHN RYLIESGNEN GFFKINQKEG ISYLHFTKKK PVAGTYSLQI SSTPLYKKKE LNQLEDKYDK DYLSGELGDN LKMKIQILLH
 3D Structure    ModBase 3D Structure for P98133
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Bos taurus (Bovine)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of FBN1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for FBN1 recombinant protein

   This gene encodes a member of the fibrillin family. The encoded protein is a large, extracellular matrix glycoprotein that serve as a structural component of 10-12 nm calcium-binding microfibrils. These microfibrils provide force bearing structural support in elastic and nonelastic connective tissue throughout the body. Mutations in this gene are associated with Marfan syndrome, isolated ectopia lentis, autosomal dominant Weill-Marchesani syndrome, MASS syndrome, and Shprintzen-Goldberg craniosynostosis syndrome.
NCBI/Uniprot data below describe general gene information for FBN1. It may not necessarily be applicable to this product.
 NCBI GI #    27806637
 NCBI GeneID    281154
 NCBI Accession #    NP_776478.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_174053.2 [Other Products]
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 UniProt Primary Accession #    P98133 [Other Products]
 UniProt Related Accession #    P98133 [Other Products]
 Molecular Weight    312,250 Da
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 NCBI Official Full Name    fibrillin-1
 NCBI Official Symbol    FBN1 [Similar Products]
 NCBI Protein Information    fibrillin-1; MP340
 UniProt Protein Name    Fibrillin-1
 UniProt Synonym Protein Names   
MP340
 Protein Family    Fibrillin
 UniProt Gene Name    FBN1 [Similar Products]
 UniProt Entry Name    FBN1_BOVIN
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 UniProt Comments for FBN1    Fibrillin-1: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles. Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11. This leads to disruption of TNFSF11-induced Ca2+ signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function. Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1. Binds heparin and this interaction plays an important role in the assembly of microfibrils.
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 Research Articles on FBN1    1. Study concludes that the c.8227-1G>A mutation is causative for Marfan syndrome-like disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FBN1 recombinant proteinPathways associated with FBN1 recombinant protein
 Reference Product  PubMed Publications
 COL1A1 recombinant protein  >7 publications with FBN1 and COL1A1
 LOX recombinant protein  >4 publications with FBN1 and LOX
 DCN recombinant protein  >4 publications with FBN1 and DCN
 LOXL1 recombinant protein  >3 publications with FBN1 and LOXL1
 ELN recombinant protein  >3 publications with FBN1 and ELN
 MFAP2 recombinant protein  >1 publications with FBN1 and MFAP2
 ITGAV recombinant protein  >1 publications with FBN1 and ITGAV
 MFAP5 recombinant protein  >1 publications with FBN1 and MFAP5
 Products by Pathway  Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
Diseases associated with FBN1 recombinant proteinOrgans/Tissues associated with FBN1 recombinant protein
 Disease Name  Pubmed Publications
 Marfan Syndrome Antibodies  >457 publications with FBN1 and Marfan Syndrome
 Cardiovascular Diseases Antibodies  >400 publications with FBN1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >377 publications with FBN1 and Heart Diseases
 Ectopia Lentis Antibodies  >90 publications with FBN1 and Ectopia Lentis
 Aortic Aneurysm, Thoracic Antibodies  >59 publications with FBN1 and Aortic Aneurysm, Thoracic
 Disease Models, Animal Antibodies  >40 publications with FBN1 and Disease Models, Animal
 Arachnodactyly Antibodies  >35 publications with FBN1 and Arachnodactyly
 Aortic Rupture Antibodies  >24 publications with FBN1 and Aortic Rupture
 Nervous System Diseases Antibodies  >18 publications with FBN1 and Nervous System Diseases
 Weill-Marchesani Syndrome Antibodies  >17 publications with FBN1 and Weill-Marchesani Syndrome
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >62 publications with FBN1 and Skin
 Muscle Antibodies  >38 publications with FBN1 and Muscle
 Lung Antibodies  >18 publications with FBN1 and Lung
 Kidney Antibodies  >10 publications with FBN1 and Kidney
 Cartilage Antibodies  >4 publications with FBN1 and Cartilage
 Brain Antibodies  >4 publications with FBN1 and Brain
 Reticulum Antibodies  >3 publications with FBN1 and Reticulum
 Ovary Antibodies  >3 publications with FBN1 and Ovary
 Intestine Antibodies  >1 publications with FBN1 and Intestine
 Pancreas Antibodies  >1 publications with FBN1 and Pancreas
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