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mFGF 21 recombinant protein :: Fibroblast Growth Factor-21 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142216 mFGF 21 recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $3,515 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fibroblast Growth Factor-21 (mFGF 21), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Fibroblast Growth Factor-21

 Product Synonym Names    FGF 21 Mouse; Fibroblast Growth Factor-21 Mouse Recombinant; Fibroblast growth factor 21; FGF-21
 Product Gene Name   

mFGF 21 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MAY PIPDSSPLLQ FGGQVRQRYL YTDDDQDTEA HLEIREDGTV VGAAHRSPES LLELKALKPG VIQILGVKAS RFLCQQPDGA LYGSPHFDPE ACSFRELLLE DGYNVYQSEA HGLPLRLPQK DSPNQDATSW GPVRFLPMPG LLHEPQDQAG FLPPEPPDVG SSDPLSMVEP LQGRSPSYAS
 3D Structure    ModBase 3D Structure for Q9JJN1
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    Filtered (0.4 um) and lyophilized from 0.5 mg/ml in 20mM TRIS, 20mM NaCl, pH 7.5.
Filtered white lyophilized powder.
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 Solubility    It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. Add DTT (0.2mM) and NaCl (0.1-0.15M) before freezing to prevent potential aggregation.
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 Preparation and Storage    Lyophilized FGF-21 Mouse Recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution Fibroblast Growth Factor 21 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of mFGF 21 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for mFGF 21 recombinant protein

   Description: Fibroblast Growth Factor -21 Mouse Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 183 amino acids including N-terminal Methionin and having a molecular mass of 20.1 kDa. The FGF-21 is purified by proprietary chromatographic techniques.

Introduction: The FGFs are a family of more than 20 small (~1726 kDa) secreted peptides. The initial characterization of these proteins focused on their ability to stimulate fibroblast proliferation. This mitogenic activity was mediated through FGF receptors (FGFRs) 1, 2, or 3. A fourth closely related tyrosine kinase receptor (FGFR4) was able to bind the FGFs but did not lead to a mitogenic response.FGFs modulate cellular activity via at least 5 distinct subfamilies of high-affinity FGF receptors (FGFRs): FGFR-1, -2, -3, and -4, all with intrinsic tyrosine kinase activity and, except for FGFR-4, multiple splice isoforms, and FGFR-5, which lacks an intracellular kinase domain. There is growing evidence that FGFRs can be important for regulation of glucose and lipid homeostasis. The overexpression of a dominant negative form of FGFR-1 in ? cells leads to diabetes in mice, which thus implies that proper FGF signaling is required for normal ? cell function and glycemia maintenance. FGFR-2 appears to be a key molecule during pancreatic development. Moreover, FGFR-4 has been implicated in cholesterol metabolism and bile acid synthesis.FGF-19, has been shown to cause resistance to diet-induced obesity and insulin desensitization and to improve insulin, glucose, and lipid profiles in diabetic rodents. Since these effects, at least in part, are mediated through the observed changes in metabolic rates, FGF-19 can be considered as a regulator of energy expenditure.FGF-21 is preferentially expressed in liver, but an exact knowledge of FGF-21 bioactivity and its mode of action have been lacking to date. FGF-21 is a potent activator of glucose uptake on adipocytes, protects animals from diet-induced obesity when overexpressed in transgenic mice, and lowers blood glucose and triglyceride levels when therapeutically administered to diabetic rodents.
 Product Categories/Family for mFGF 21 recombinant protein    CYTOKINES AND GROWTH FACTORS; Growth Factors; Fibroblast Growth Factor
NCBI/Uniprot data below describe general gene information for mFGF 21. It may not necessarily be applicable to this product.
 NCBI GI #    9910218
 NCBI GeneID    56636
 NCBI Accession #    NP_064397.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_020013.4 [Other Products]
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 UniProt Primary Accession #    Q9JJN1 [Other Products]
 UniProt Related Accession #    Q9JJN1 [Other Products]
 Molecular Weight    23,237 Da
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 NCBI Official Full Name    fibroblast growth factor 21
 NCBI Official Synonym Full Names    fibroblast growth factor 21
 NCBI Official Symbol    Fgf21 [Similar Products]
 NCBI Protein Information    fibroblast growth factor 21; FGF-21
 UniProt Protein Name    Fibroblast growth factor 21
 UniProt Gene Name    Fgf21 [Similar Products]
 UniProt Synonym Gene Names    FGF-21 [Similar Products]
 UniProt Entry Name    FGF21_MOUSE
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 UniProt Comments for mFGF 21    FGF21: Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Belongs to the heparin-binding growth factors family.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular region

Molecular Function: growth factor activity; fibroblast growth factor receptor binding; receptor binding

Biological Process: positive regulation of glucose import; fibroblast growth factor receptor signaling pathway; positive regulation of cell proliferation
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 Research Articles on mFGF 21    1. The IRE1alpha-XBP1 pathway of the unfolded protein response could directly activate the transcriptional expression of Fgf21.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with mFGF 21 recombinant proteinPathways associated with mFGF 21 recombinant protein
 Reference Product  PubMed Publications
 Klb recombinant protein  >41 publications with mFGF 21 and Klb
 Fgfr1 recombinant protein  >41 publications with mFGF 21 and Fgfr1
 Fgfr4 recombinant protein  >19 publications with mFGF 21 and Fgfr4
 Sirt1 recombinant protein  >10 publications with mFGF 21 and Sirt1
 Fgfr2 recombinant protein  >8 publications with mFGF 21 and Fgfr2
 Fgfr3 recombinant protein  >7 publications with mFGF 21 and Fgfr3
 Akt1 recombinant protein  >6 publications with mFGF 21 and Akt1
 Cyp7a1 recombinant protein  >5 publications with mFGF 21 and Cyp7a1
 Insr recombinant protein  >1 publications with mFGF 21 and Insr
 Products by Pathway  Pathway Diagram
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 Melanoma Pathway antibodies  Melanoma Pathway Diagram
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 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
Diseases associated with mFGF 21 recombinant proteinOrgans/Tissues associated with mFGF 21 recombinant protein
 Disease Name  Pubmed Publications
 Obesity Antibodies  >209 publications with mFGF 21 and Obesity
 Insulin Resistance Antibodies  >162 publications with mFGF 21 and Insulin Resistance
 Fatty Liver Antibodies  >147 publications with mFGF 21 and Fatty Liver
 Hyperinsulinism Antibodies  >101 publications with mFGF 21 and Hyperinsulinism
 Liver Diseases Antibodies  >92 publications with mFGF 21 and Liver Diseases
 Diabetes Mellitus, Type 2 Antibodies  >71 publications with mFGF 21 and Diabetes Mellitus, Type 2
 Inflammation Antibodies  >49 publications with mFGF 21 and Inflammation
 Disease Models, Animal Antibodies  >44 publications with mFGF 21 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >44 publications with mFGF 21 and Cardiovascular Diseases
 Weight Loss Antibodies  >36 publications with mFGF 21 and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >305 publications with mFGF 21 and Liver
 Pancreas Antibodies  >23 publications with mFGF 21 and Pancreas
 Testis Antibodies  >1 publications with mFGF 21 and Testis
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