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mFGF 8 recombinant protein :: Fibroblast Growth Factor-8 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS144417 mFGF 8 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fibroblast Growth Factor-8 (mFGF 8), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Fibroblast Growth Factor-8

 Product Synonym Names    FGF 8 Mouse; Fibroblast Growth Factor-8 Mouse Recombinant; Fibroblast growth factor 8; FGF-8; Androgen-induced growth factor; AIGF; Heparin-binding growth factor 8; HBGF-8; Fgf8
 Product Gene Name   

mFGF 8 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P37237
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
 Form/Format    FGF-8 protein was lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized FGF-8 in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
 Biological Activity    The ED50, as determined by the dose-dependent a cell proliferation assay using NR6R-3T3 mouse fibroblast cells is <25 ng/ml in the presence of 0.1 ug/ml heprin, corresponding to a specific activity of > 4.0x104 units/mg.
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 Preparation and Storage    Lyophilized FGF-8 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution FGF-8 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of mFGF 8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for mFGF 8 recombinant protein

   Description: FGF-8 Mouse Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 246 amino acids and having a molecular mass of 28.1kDa.The FGF-8 is purified by proprietary chromatographic techniques.

Introduction: FGF8 is part of the fibroblast growth factor family. FGF family members have wide mitogenic and cell survival activities, and participate in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF8 supports androgen and anchorage independent growth of mammary tumor cells. FGF8 over expression increases tumor growth and angiogensis. The adult expression of FGF-8 gene is restricted to testes and ovaries. FGF8 functions as an embryonic epithelial factor. FGF8 takes part in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination.
 Product Categories/Family for mFGF 8 recombinant protein    CYTOKINES AND GROWTH FACTORS; Growth Factors; Fibroblast Growth Factor
NCBI/Uniprot data below describe general gene information for mFGF 8. It may not necessarily be applicable to this product.
 NCBI GI #    261599076
 NCBI GeneID    14179
 NCBI Accession #    NP_001159834.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001166362.1 [Other Products]
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 UniProt Primary Accession #    P37237 [Other Products]
 UniProt Related Accession #    P37237 [Other Products]
 Molecular Weight    23,522 Da
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 NCBI Official Full Name    fibroblast growth factor 8 isoform 3
 NCBI Official Synonym Full Names    fibroblast growth factor 8
 NCBI Official Symbol    Fgf8 [Similar Products]
 NCBI Official Synonym Symbols   
Aigf; Fgf-8
[Similar Products]
 NCBI Protein Information    fibroblast growth factor 8; HBGF-8; androgen-induced growth factor; heparin-binding growth factor 8
 UniProt Protein Name    Fibroblast growth factor 8
 UniProt Synonym Protein Names   
Androgen-induced growth factor; AIGF; Heparin-binding growth factor 8; HBGF-8
 UniProt Gene Name    Fgf8 [Similar Products]
 UniProt Synonym Gene Names    Aigf; FGF-8; AIGF; HBGF-8 [Similar Products]
 UniProt Entry Name    FGF8_MOUSE
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 UniProt Comments for mFGF 8    FGF8: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Defects in FGF8 are the cause of Kallmann syndrome type 6 (KAL6). Kallmann syndrome is a disorder that associates hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone- synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous. Defects in FGF8 are a cause of idiopathic hypogonadotropic hypogonadism (IHH). IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. Belongs to the heparin-binding growth factors family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; Cytokine

Cellular Component: extracellular space; extracellular region; intracellular; external side of plasma membrane

Molecular Function: growth factor activity; type 2 fibroblast growth factor receptor binding; receptor binding; fibroblast growth factor receptor binding; type 1 fibroblast growth factor receptor binding; chemoattractant activity

Biological Process: heart morphogenesis; heart development; multicellular organismal development; adrenocorticotropin hormone secreting cell differentiation; motor axon guidance; Wnt receptor signaling pathway through beta-catenin; mesodermal cell migration; BMP signaling pathway; positive chemotaxis; induction of an organ; male genitalia development; pallium development; negative regulation of neuron apoptosis; kidney development; regulation of odontogenesis of dentine-containing teeth; central nervous system neuron development; inner ear morphogenesis; fibroblast growth factor receptor signaling pathway; cell fate commitment; positive regulation of mitosis; neural plate morphogenesis; subpallium development; forebrain morphogenesis; dorsal/ventral axon guidance; patterning of blood vessels; forebrain neuron development; positive regulation of cell division; midbrain-hindbrain boundary development; response to oxidative stress; determination of left/right symmetry; negative regulation of apoptosis; gonad development; apoptosis; cell proliferation in forebrain; forebrain dorsal/ventral pattern formation; thyroid stimulating hormone secreting cell differentiation; embryonic hindlimb morphogenesis; embryonic development ending in birth or egg hatching; positive regulation of cell proliferation; thyroid gland development; heart looping; cell differentiation; otic vesicle formation; negative regulation of cardiac muscle development; pharyngeal system development; MAPKKK cascade; limb morphogenesis; positive regulation of organ growth; telencephalon development; generation of neurons; ureteric bud branching; embryonic heart tube development; blood vessel remodeling; lung development
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 Research Articles on mFGF 8    1. Results show that DLX5, p63, Pin1 and FGF8 participate to the same time- and location-restricted regulatory loop essential for apical ectodermal ridge stratification, hence for normal patterning and skeletal morphogenesis of the limb buds.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with mFGF 8 recombinant proteinPathways associated with mFGF 8 recombinant protein
 Reference Product  PubMed Publications
 Fgfr1 recombinant protein  >114 publications with mFGF 8 and Fgfr1
 Otx2 recombinant protein  >93 publications with mFGF 8 and Otx2
 Fgf4 recombinant protein  >91 publications with mFGF 8 and Fgf4
 Fgf10 recombinant protein  >90 publications with mFGF 8 and Fgf10
 Gbx2 recombinant protein  >62 publications with mFGF 8 and Gbx2
 Fgfr2 recombinant protein  >48 publications with mFGF 8 and Fgfr2
 En1 recombinant protein  >47 publications with mFGF 8 and En1
 Fgfr3 recombinant protein  >37 publications with mFGF 8 and Fgfr3
 Fgfr4 recombinant protein  >21 publications with mFGF 8 and Fgfr4
 Fgf15 recombinant protein  >12 publications with mFGF 8 and Fgf15
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Diseases associated with mFGF 8 recombinant proteinOrgans/Tissues associated with mFGF 8 recombinant protein
 Disease Name  Pubmed Publications
 Craniofacial Abnormalities Antibodies  >80 publications with mFGF 8 and Craniofacial Abnormalities
 Nervous System Diseases Antibodies  >59 publications with mFGF 8 and Nervous System Diseases
 Abnormalities, Multiple Antibodies  >57 publications with mFGF 8 and Abnormalities, Multiple
 Genital Diseases, Male Antibodies  >49 publications with mFGF 8 and Genital Diseases, Male
 Disease Models, Animal Antibodies  >44 publications with mFGF 8 and Disease Models, Animal
 Kallmann Syndrome Antibodies  >41 publications with mFGF 8 and Kallmann Syndrome
 Cardiovascular Abnormalities Antibodies  >36 publications with mFGF 8 and Cardiovascular Abnormalities
 Heart Defects, Congenital Antibodies  >31 publications with mFGF 8 and Heart Defects, Congenital
 Cleft Palate Antibodies  >29 publications with mFGF 8 and Cleft Palate
 Heart Diseases Antibodies  >26 publications with mFGF 8 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >373 publications with mFGF 8 and Embryonic Tissue
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