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FGF 9 recombinant protein :: Fibroblast Growth Factor-9 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142291 FGF 9 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $3,435 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fibroblast Growth Factor-9 (FGF 9), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Fibroblast Growth Factor-9

 Product Synonym Names    FGF 9 Human; Fibroblast Growth Factor-9 Human Recombinant; GAF (Glia-activating factor); HBGF-9; MGC119914; MGC119915; FGF-9
 Product Gene Name   

FGF 9 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    APLGEVGNYF GVQDAVPFGN VPVLPVDSPV LLSDHLGQSE AGGLPRGPAV TDLDHLKGIL RRRQLYCRTG FHLEIFPNGT IQGTRKDHSR FGILEFISIA VGLVSIRGVD SGLYLGMNEK GELYGSEKLT QECVFREQFE ENWYNTYSSN LYKHVDTGRR YYVALNKDGT PREGTRTKRH QKFTHFLPRP VDPDKVPELY KDILSQS.
 OMIM    600921
 3D Structure    ModBase 3D Structure for P31371
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by RP-HPLC and SDS-PAGE.
 Form/Format    The sterile protein powder is lyophilized from 1mg/ml solution containing 1xPBS.
Sterile Filtered white lyophilized powder.
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 Solubility    It is recommended to reconstitute the lyophilized Fibroblast Growth Factor-9 Human Recombinant sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
 Biological Activity    The ED50, calculated by the dose-dependant proliferation of BAF3 cells expressing FGF receptors (measured by 3H-thymidine uptake) is <0.5ng/ml, corresponding to a specific activity of 2,000,000 Units/mg.
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 Preparation and Storage    Lyophilized Fibroblast Growth Factor 9 Human Recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution FGF-9 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of FGF 9 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for FGF 9 recombinant protein

   Description: Fibroblast Growth Factor-9 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 207 amino acids and having a molecular mass of 23.4 kDa. The FGF-9 is purified by proprietary chromatographic techniques.

Introduction: The human FGF-9 cDNA encodes a 208 amino acid residue protein that contains a single, potential N-linked glycosylation site. The native protein is glycosylated and is efficiently secreted after synthesis, although FGF -9 lacks a typical secretion signal. Rat and mouse FGF-9 show a very high homology to human FGF-9. The transcripts for FGF-9 have been found in brain and in kidney tissue. Fibroblast Growth Factor-9 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF9 was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog (Shh) signaling. Mice lacking the homolog gene displayed a male-to-female sex reversal phenotype, which suggested a role in testicular embryogenesis Fibroblast Growth Factor 9 may have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
 Product Categories/Family for FGF 9 recombinant protein    CYTOKINES AND GROWTH FACTORS; Growth Factors; Fibroblast Growth Factor
NCBI/Uniprot data below describe general gene information for FGF 9. It may not necessarily be applicable to this product.
 NCBI GI #    4503707
 NCBI GeneID    2254
 NCBI Accession #    NP_002001.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002010.2 [Other Products]
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 UniProt Primary Accession #    P31371 [Other Products]
 UniProt Secondary Accession #    Q3SY32; A8K427 [Other Products]
 UniProt Related Accession #    P31371 [Other Products]
 Molecular Weight    23,441 Da
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 NCBI Official Full Name    fibroblast growth factor 9
 NCBI Official Synonym Full Names    fibroblast growth factor 9
 NCBI Official Symbol    FGF9 [Similar Products]
 NCBI Official Synonym Symbols   
GAF; FGF-9; SYNS3; HBFG-9; HBGF-9
[Similar Products]
 NCBI Protein Information    fibroblast growth factor 9; fibroblast growth factor 9 (glia-activating factor); heparin-binding growth factor 9
 UniProt Protein Name    Fibroblast growth factor 9
 UniProt Synonym Protein Names   
Glia-activating factor; GAF; Heparin-binding growth factor 9; HBGF-9
 UniProt Gene Name    FGF9 [Similar Products]
 UniProt Synonym Gene Names    FGF-9; GAF; HBGF-9 [Similar Products]
 UniProt Entry Name    FGF9_HUMAN
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 NCBI Summary for FGF 9    The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog (Shh) signaling. Mice lacking the homolog gene displayed a male-to-female sex reversal phenotype, which suggested a role in testicular embryogenesis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FGF 9    FGF9: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors. Defects in FGF9 are the cause of multiple synostoses syndrome type 3 (SYNS3). Multiple synostoses syndrome is an autosomal dominant condition characterized by progressive joint fusions of the fingers, wrists, ankles and cervical spine, characteristic facies and progressive conductive deafness. Belongs to the heparin-binding growth factors family.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 13q11-q12

Cellular Component: extracellular space; cytoplasm; extracellular region; basement membrane

Molecular Function: heparin binding; growth factor activity; fibroblast growth factor receptor binding

Biological Process: negative regulation of Wnt receptor signaling pathway; nerve growth factor receptor signaling pathway; embryonic skeletal development; negative regulation of transcription from RNA polymerase II promoter; signal transduction; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of activin receptor signaling pathway; substantia nigra development; cell-cell signaling; positive regulation of MAPKKK cascade; protein import into nucleus; male sex determination; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; chondrocyte differentiation; positive regulation of smoothened signaling pathway; angiogenesis; regulation of timing of cell differentiation; embryonic gut development; positive regulation of cardiac muscle cell proliferation; embryonic limb morphogenesis; epidermal growth factor receptor signaling pathway; inner ear morphogenesis; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; male gonad development; osteoblast differentiation; positive regulation of cell division; insulin receptor signaling pathway; innate immune response; positive regulation of epithelial cell proliferation

Disease: Multiple Synostoses Syndrome 3
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 Research Articles on FGF 9    1. expression is associated with poor prognosis in lung cancer
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FGF 9 recombinant proteinPathways associated with FGF 9 recombinant protein
 Reference Product  PubMed Publications
 FGFR2 recombinant protein  >54 publications with FGF 9 and FGFR2
 FGFR3 recombinant protein  >52 publications with FGF 9 and FGFR3
 FGF10 recombinant protein  >39 publications with FGF 9 and FGF10
 FGFR1 recombinant protein  >37 publications with FGF 9 and FGFR1
 FGF7 recombinant protein  >27 publications with FGF 9 and FGF7
 FGF4 recombinant protein  >23 publications with FGF 9 and FGF4
 FGFR4 recombinant protein  >11 publications with FGF 9 and FGFR4
 FGF6 recombinant protein  >7 publications with FGF 9 and FGF6
 FGF23 recombinant protein  >5 publications with FGF 9 and FGF23
 FGF19 recombinant protein  >3 publications with FGF 9 and FGF19
 Products by Pathway  Pathway Diagram
 Activated Point Mutants Of FGFR2 Pathway antibodies  Activated Point Mutants Of FGFR2 Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 FGFR Ligand Binding And Activation Pathway antibodies  FGFR Ligand Binding And Activation Pathway Diagram
Diseases associated with FGF 9 recombinant proteinOrgans/Tissues associated with FGF 9 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >14 publications with FGF 9 and Nervous System Diseases
 Adenocarcinoma Antibodies  >14 publications with FGF 9 and Adenocarcinoma
 Lung Diseases Antibodies  >10 publications with FGF 9 and Lung Diseases
 Urogenital Abnormalities Antibodies  >9 publications with FGF 9 and Urogenital Abnormalities
 Hypertrophy Antibodies  >8 publications with FGF 9 and Hypertrophy
 Cardiovascular Diseases Antibodies  >8 publications with FGF 9 and Cardiovascular Diseases
 Lung Neoplasms Antibodies  >7 publications with FGF 9 and Lung Neoplasms
 Hyperplasia Antibodies  >6 publications with FGF 9 and Hyperplasia
 Heart Diseases Antibodies  >6 publications with FGF 9 and Heart Diseases
 Inflammation Antibodies  >5 publications with FGF 9 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >56 publications with FGF 9 and Testis
 Embryonic Tissue Antibodies  >46 publications with FGF 9 and Embryonic Tissue
 Lung Antibodies  >40 publications with FGF 9 and Lung
 Brain Antibodies  >36 publications with FGF 9 and Brain
 Blood Antibodies  >23 publications with FGF 9 and Blood
 Heart Antibodies  >14 publications with FGF 9 and Heart
 Eye Antibodies  >12 publications with FGF 9 and Eye
 Kidney Antibodies  >12 publications with FGF 9 and Kidney
 Connective Tissue Antibodies  >11 publications with FGF 9 and Connective Tissue
 Intestine Antibodies  >8 publications with FGF 9 and Intestine
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