NP_077060.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
91,825 Da
NCBI Official Full Name
fibroblast growth factor receptor 1
NCBI Official Synonym Full Names
Fibroblast growth factor receptor 1
NCBI Protein Information
fibroblast growth factor receptor 1
UniProt Protein Name
Fibroblast growth factor receptor 1
UniProt Synonym Protein Names
Basic fibroblast growth factor receptor 1; MFR; Proto-oncogene c-Fgr; CD_antigen: CD331
UniProt Synonym Gene Names
UniProt Entry Name
FGFR1_RAT
NCBI Summary for FGFR1
proportion of transmembrane and soluble extracellular isoforms may modulate fibroblast growth factor signaling; plays a role in regulation of neuronal cell proliferation [RGD, Feb 2006]
UniProt Comments for FGFR1
FGFR1 iso2: a receptor tyrosine kinase of the highly-conserved fibroblast growth factor receptor (FGFR). Binds both acidic and basic fibroblast growth factors and is involved in limb induction. Point mutations cause Pfeffer syndrome (finger and toe malformations and other skeletal errors) and dominant Kallmann syndrome 2. Stem cell leukemia lymphoma syndrome (SCLL) may be caused by a t(8;13)(p12;q12) translocation that fuses a zinc finger gene, ZNF198, to FGFR1. Various myeloproliferative disorders have been linked to translocations that fuse FGFR1 to FOP, FIM, CEP1 or the atypical kinase, Bcr. Inhibitor: SU5402. 20 isoforms of the human protein produced by alternative splicing have been described.
Protein type: EC 2.7.10.1; Oncoprotein; Kinase, protein; Protein kinase, tyrosine (receptor); Protein kinase, TK; Membrane protein, integral; TK group; FGFR family
Cellular Component: cytoplasmic membrane-bound vesicle; integral to membrane; plasma membrane; nucleus; cytosol; receptor complex
Molecular Function: heparin binding; identical protein binding; protein binding; protein homodimerization activity; fibroblast growth factor binding; fibroblast growth factor receptor activity; protein-tyrosine kinase activity; protein complex binding; cell adhesion molecule binding; glycoprotein binding; ATP binding
Biological Process: paraxial mesoderm development; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; cell maturation; middle ear morphogenesis; negative regulation of transcription from RNA polymerase II promoter; orbitofrontal cortex development; positive regulation of MAP kinase activity; sensory perception of sound; positive regulation of MAPKKK cascade; ureteric bud development; induction of an organ; salivary gland morphogenesis; positive regulation of cell proliferation; midbrain development; positive regulation of mesenchymal cell proliferation; chondrocyte differentiation; negative regulation of osteoblast differentiation; angiogenesis; neurite development; embryonic limb morphogenesis; central nervous system neuron development; positive regulation of cardiac muscle cell proliferation; inner ear morphogenesis; fibroblast growth factor receptor signaling pathway; motogenic signaling involved in postnatal olfactory bulb interneuron migration; in utero embryonic development; stem cell maintenance; outer ear morphogenesis; positive regulation of cell cycle; regulation of cell proliferation; neuroblast division in the ventricular zone; mesenchymal cell differentiation; generation of neurons; regulation of gene expression; blood vessel morphogenesis; auditory receptor cell development; positive regulation of transcription from RNA polymerase II promoter; regulation of sensory perception of pain; brain development; positive regulation of neuron differentiation; regulation of lateral mesodermal cell fate specification; lung development
Research Articles on FGFR1
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Products associated with FGFR1 recombinant protein
Pathways associated with FGFR1 recombinant protein
Diseases associated with FGFR1 recombinant protein
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