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FGFR4 recombinant protein :: Fibroblast Growth Factor Receptor-4 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142779 FGFR4 recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $5,015 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fibroblast Growth Factor Receptor-4 (FGFR4), Recombinant Protein

 Also Known As   

Recombinant Human Fibroblast Growth Factor Receptor-4

 Product Synonym Names    FGFR4 Human; Fibroblast Growth Factor Receptor 4 Fc Chimera Human Recombinant; CD334; TKF; JTK2; FGFR4
 Product Gene Name   

FGFR4 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    134935
 3D Structure    ModBase 3D Structure for P22455
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 Host    Insect Cells
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 Purity/Purification    Greater than 90.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
 Form/Format    CD334 was lyophilized from a concentrated (1 mg/ml) sterile solution containing no additives.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized FGFR-4 in sterile PBS not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
 Biological Activity    Determined by its ability to inhibit human FGF acidic-dependent proliferation on R1 cells. The ED50 for this effect is typically at 15.0-30.0 ng/ml.
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 Preparation and Storage    Lyophilized FGFR4 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution FGFR4 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of FGFR4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for FGFR4 recombinant protein

   Description: Soluble FGFR-4a (IIIc) Fc Chimera Human Recombinant fused with Xa cleavage site with the Fc part of human IgG1 produced in baculovirus is a heterodimeric, glycosylated, Polypeptide chain and having a molecular mass of 170 kDa. The FGFR4 is purified by proprietary chromatographic techniques.

Introduction: Fibroblast growth factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentiation, angiogenesis, wound healing and tumorgenesis. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding. Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid-box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain. Multiple forms of FGF R1 - 3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGF R1 and 2 results in receptors containing all three Ig domains, referred to as the a isoform, or only IgII and IgIII, referred to as the b isoform. Only the a isoform has been identified for FGF R3 and FGF R4. Additional splicing events for FGF R1 - 3, involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons, generate FGF receptors with alternative IgIII domains (IIIb and IIIc). A IIIa isoform which is a secreted FGF binding protein containing only the N-terminal half of the IgIII domain plus some intron sequences has also been reported for FGF R1. Mutations in FGF R1 - 3 have been found in patients with birth defects involving craniosynostosis. The complex patterns of expression of these receptors as well as the specificity of their interactions with the various FGF ligand family members are under investigation.
 Product Categories/Family for FGFR4 recombinant protein    PROTEIN KINASES; Enzymes; FGF Receptors
NCBI/Uniprot data below describe general gene information for FGFR4. It may not necessarily be applicable to this product.
 NCBI GI #    634743314
 NCBI GeneID    2264
 NCBI Accession #    NP_001278909.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001291980.1 [Other Products]
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 UniProt Primary Accession #    P22455 [Other Products]
 UniProt Secondary Accession #    O43785; Q14309; Q71TW8; Q8TDA0; Q96KE5; G3JVM2; G3JVM5; G3JVM7; G3JVM9 [Other Products]
 UniProt Related Accession #    P22455; AAB25788 [Other Products]
 Molecular Weight    64,640 Da
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 NCBI Official Full Name    fibroblast growth factor receptor 4 isoform 3
 NCBI Official Synonym Full Names    fibroblast growth factor receptor 4
 NCBI Official Symbol    FGFR4 [Similar Products]
 NCBI Official Synonym Symbols   
TKF; JTK2; CD334
[Similar Products]
 NCBI Protein Information    fibroblast growth factor receptor 4; hydroxyaryl-protein kinase; protein-tyrosine kinase; tyrosine kinase related to fibroblast growth factor receptor; tyrosylprotein kinase
 UniProt Protein Name    Fibroblast growth factor receptor 4
 UniProt Synonym Protein Names   
CD_antigen: CD334
 Protein Family    Fibroblast growth factor receptor
 UniProt Gene Name    FGFR4 [Similar Products]
 UniProt Synonym Gene Names    JTK2; TKF; FGFR-4 [Similar Products]
 UniProt Entry Name    FGFR4_HUMAN
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 NCBI Summary for FGFR4    The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FGFR4    FGFR4: a tyrosine-kinase receptor that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of the MAP kinase and AKT signaling pathways. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling. Two isoforms of the human protein are formed by alternative splicing. This description may include information from UniProtKB

Protein type: Protein kinase, TK; Kinase, protein; Membrane protein, integral; Protein kinase, tyrosine (receptor); EC 2.7.10.1; TK group; FGFR family

Chromosomal Location of Human Ortholog: 5q35.2

Cellular Component: nucleoplasm; Golgi apparatus; transport vesicle; endoplasmic reticulum; integral to plasma membrane; cytoplasm; extracellular region; plasma membrane; intercellular junction; endosome

Molecular Function: heparin binding; protein binding; fibroblast growth factor binding; fibroblast growth factor receptor activity; protein-tyrosine kinase activity; ATP binding

Biological Process: epidermal growth factor receptor signaling pathway; cell migration; peptidyl-tyrosine phosphorylation; regulation of lipid metabolic process; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; positive regulation of proteolysis; protein amino acid autophosphorylation; positive regulation of metalloenzyme activity; glucose homeostasis; induction of an organ; positive regulation of cell proliferation; insulin receptor signaling pathway; innate immune response; phosphate ion homeostasis
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 Research Articles on FGFR4    1. The FGFR4 transmembrane polymorphic variants can modulate cellular growth and sensitivity to glucocorticoid hormone negative feedback.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FGFR4 recombinant proteinPathways associated with FGFR4 recombinant protein
 Reference Product  PubMed Publications
 FGF2 recombinant protein  >68 publications with FGFR4 and FGF2
 FGF19 recombinant protein  >65 publications with FGFR4 and FGF19
 FGF1 recombinant protein  >56 publications with FGFR4 and FGF1
 KLB recombinant protein  >25 publications with FGFR4 and KLB
 FGF21 recombinant protein  >19 publications with FGFR4 and FGF21
 FGF4 recombinant protein  >17 publications with FGFR4 and FGF4
 FGF6 recombinant protein  >15 publications with FGFR4 and FGF6
 FGF9 recombinant protein  >11 publications with FGFR4 and FGF9
 FGF3 recombinant protein  >9 publications with FGFR4 and FGF3
 FGF5 recombinant protein  >5 publications with FGFR4 and FGF5
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
Diseases associated with FGFR4 recombinant proteinOrgans/Tissues associated with FGFR4 recombinant protein
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >52 publications with FGFR4 and Breast Neoplasms
 Liver Diseases Antibodies  >31 publications with FGFR4 and Liver Diseases
 Brain Diseases Antibodies  >27 publications with FGFR4 and Brain Diseases
 Carcinoma, Hepatocellular Antibodies  >25 publications with FGFR4 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >24 publications with FGFR4 and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >21 publications with FGFR4 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >21 publications with FGFR4 and Disease Models, Animal
 Lung Neoplasms Antibodies  >20 publications with FGFR4 and Lung Neoplasms
 Lung Diseases Antibodies  >18 publications with FGFR4 and Lung Diseases
 Neoplasm Metastasis Antibodies  >16 publications with FGFR4 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >80 publications with FGFR4 and Liver
 Muscle Antibodies  >60 publications with FGFR4 and Muscle
 Embryonic Tissue Antibodies  >52 publications with FGFR4 and Embryonic Tissue
 Blood Antibodies  >47 publications with FGFR4 and Blood
 Lung Antibodies  >39 publications with FGFR4 and Lung
 Brain Antibodies  >37 publications with FGFR4 and Brain
 Intestine Antibodies  >22 publications with FGFR4 and Intestine
 Kidney Antibodies  >21 publications with FGFR4 and Kidney
 Nerve Antibodies  >20 publications with FGFR4 and Nerve
 Lymph Antibodies  >20 publications with FGFR4 and Lymph
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