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FGF 1 recombinant protein :: Fibroblast Growth Factor-acidic Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142241 FGF 1 recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $6,270 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fibroblast Growth Factor-acidic (FGF 1), Recombinant Protein

 Also Known As   

Recombinant Human Fibroblast Growth Factor-acidic, Sf9

 Product Synonym Names    FGF 1 Human, Sf9; Fibroblast Growth Factor-Acidic Human Recombinant, Sf9; HBGF-1; ECGF-beta; FIBP; FGFIBP; FIBP-1; ECGF; ECGFA; GLIO703; FGF1; FGF-a; FGF 1 Sf9
 Product Gene Name   

FGF 1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The sequence of the first five N-terminal amino acids as determined and was found to be Met-Phe-As n-Leu-Pro.
 OMIM    131220
 3D Structure    ModBase 3D Structure for P05230
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 Host    Baculovirus
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 Purity/Purification    Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
 Form/Format    The sterile protein solution (1.8mg/ml) contains 20mM Tris HCl pH=7.9, 100mM KCl, 0.2mM DTT and 20% glycerol.
Sterile Filtered liquid formulation.
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 Biological Activity    The ED50, calculated by the dose-dependant proliferation of BAF3 cells expressing FGF receptors (measured by 3H-thymidine uptake) is <10 ng/ml, corresponding to a specific activity of 100,000IU/mg.
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 Preparation and Storage    Fibroblast Growth Factor-acidic although stable at 4 degree C for 3 weeks, should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of FGF 1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for FGF 1 recombinant protein

   Description: Fibroblast Growth Factor-1 Human Recombinant (FGF-1) produced in Sf9 insect cells is a single, glycosylated, polypeptide chain containing 140 amino acids and having a molecular mass of 15803 Dalton. The FGF-a is purified by proprietary chromatographic techniques.

Introduction: Acidic fibroblast growth factor is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Three alternatively spliced variants encoding different isoforms have been described. The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors.
 Product Categories/Family for FGF 1 recombinant protein    CYTOKINES AND GROWTH FACTORS; Growth Factors; Fibroblast Growth Factor
NCBI/Uniprot data below describe general gene information for FGF 1. It may not necessarily be applicable to this product.
 NCBI GI #    4503697
 NCBI GeneID    2246
 NCBI Accession #    NP_000791.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000800.4 [Other Products]
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 UniProt Primary Accession #    P05230 [Other Products]
 UniProt Secondary Accession #    P07502; Q16588; B2R5T0; D3DQF2 [Other Products]
 UniProt Related Accession #    P05230 [Other Products]
 Molecular Weight    6,698 Da
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 NCBI Official Full Name    fibroblast growth factor 1 isoform 1
 NCBI Official Synonym Full Names    fibroblast growth factor 1 (acidic)
 NCBI Official Symbol    FGF1 [Similar Products]
 NCBI Official Synonym Symbols   
AFGF; ECGF; FGFA; ECGFA; ECGFB; FGF-1; HBGF1; HBGF-1; GLIO703; ECGF-beta; FGF-alpha
[Similar Products]
 NCBI Protein Information    fibroblast growth factor 1; beta-endothelial cell growth factor; endothelial cell growth factor, alpha; endothelial cell growth factor, beta; heparin-binding growth factor 1
 UniProt Protein Name    Fibroblast growth factor 1
 UniProt Synonym Protein Names   
Acidic fibroblast growth factor; aFGF; Endothelial cell growth factor; ECGF; Heparin-binding growth factor 1; HBGF-1
 UniProt Gene Name    FGF1 [Similar Products]
 UniProt Synonym Gene Names    FGFA; FGF-1; aFGF; ECGF; HBGF-1 [Similar Products]
 UniProt Entry Name    FGF1_HUMAN
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 NCBI Summary for FGF 1    The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]
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 UniProt Comments for FGF 1    FGF1: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; Cytokine; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: nucleoplasm; extracellular space; proteinaceous extracellular matrix; nucleolus; extracellular region; cell cortex; cytosol

Molecular Function: heparin binding; protein binding; growth factor activity; Hsp70 protein binding; fibroblast growth factor receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; anatomical structure morphogenesis; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; multicellular organismal development; positive regulation of cholesterol biosynthetic process; signal transduction; positive regulation of MAP kinase activity; positive regulation of angiogenesis; positive regulation of cell division; induction of an organ; positive regulation of cell proliferation; insulin receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; positive regulation of epithelial cell proliferation; positive regulation of cell migration; lung development
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 Research Articles on FGF 1    1. While results are awaited from these clinical investigations in squamous NSCLC and other disease settings, additional research is needed to elucidate the role of FGF/FGFR signaling in the biology of NSCLC of different histologies
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to Recombinant Human Fibroblast Growth Factor-acidic, Sf9
 Catalog #  Product Name  Catalog #  Product Name
 MBS144738  Recombinant Mouse Fibroblast Growth Factor-acidic, His Tag  MBS143188  Recombinant Mouse Fibroblast Growth Factor-acidic
 MBS319027  Human FGF-acidic, Recombinant  MBS555541  Recombinant Human Fibroblast Growth Factor-acidic
 MBS142141  Recombinant Human Fibroblast Growth Factor-acidic  MBS143477  Bovine Fibroblast Growth Factor-acidic
 MBS555540  Recombinant Human Fibroblast Growth Factor-acidic-Sf9 Insect Cells derived  MBS145008  Recombinant Rat Fibroblast Growth Factor-acidic
 MBS142241  Recombinant Human Fibroblast Growth Factor-acidic, Sf9
Products associated with FGF 1 recombinant proteinPathways associated with FGF 1 recombinant protein
 Reference Product  PubMed Publications
 FGFR1 recombinant protein  >221 publications with FGF 1 and FGFR1
 FGFR2 recombinant protein  >123 publications with FGF 1 and FGFR2
 FGFR3 recombinant protein  >67 publications with FGF 1 and FGFR3
 FGFR4 recombinant protein  >56 publications with FGF 1 and FGFR4
 S100A13 recombinant protein  >31 publications with FGF 1 and S100A13
 SYT1 recombinant protein  >15 publications with FGF 1 and SYT1
 EGFR recombinant protein  >14 publications with FGF 1 and EGFR
 GRB2 recombinant protein  >11 publications with FGF 1 and GRB2
 FGF23 recombinant protein  >7 publications with FGF 1 and FGF23
 FGFBP1 recombinant protein  >5 publications with FGF 1 and FGFBP1
 Products by Pathway  Pathway Diagram
 Activated Point Mutants Of FGFR2 Pathway antibodies  Activated Point Mutants Of FGFR2 Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 FGF Signaling Pathway antibodies  FGF Signaling Pathway Diagram
Diseases associated with FGF 1 recombinant proteinOrgans/Tissues associated with FGF 1 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >137 publications with FGF 1 and Nervous System Diseases
 Heart Diseases Antibodies  >63 publications with FGF 1 and Heart Diseases
 Inflammation Antibodies  >60 publications with FGF 1 and Inflammation
 Necrosis Antibodies  >59 publications with FGF 1 and Necrosis
 Myocardial Ischemia Antibodies  >55 publications with FGF 1 and Myocardial Ischemia
 Neoplasms, Experimental Antibodies  >43 publications with FGF 1 and Neoplasms, Experimental
 Hyperplasia Antibodies  >39 publications with FGF 1 and Hyperplasia
 Fibrosis Antibodies  >35 publications with FGF 1 and Fibrosis
 Cell Transformation, Neoplastic Antibodies  >33 publications with FGF 1 and Cell Transformation, Neoplastic
 Liver Diseases Antibodies  >33 publications with FGF 1 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >300 publications with FGF 1 and Brain
 Muscle Antibodies  >249 publications with FGF 1 and Muscle
 Nerve Antibodies  >193 publications with FGF 1 and Nerve
 Embryonic Tissue Antibodies  >169 publications with FGF 1 and Embryonic Tissue
 Bone Antibodies  >149 publications with FGF 1 and Bone
 Heart Antibodies  >119 publications with FGF 1 and Heart
 Liver Antibodies  >116 publications with FGF 1 and Liver
 Lung Antibodies  >115 publications with FGF 1 and Lung
 Eye Antibodies  >106 publications with FGF 1 and Eye
 Skin Antibodies  >84 publications with FGF 1 and Skin
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