View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List Fibroblast growth factor 21 Recombinant Protein Catalog # MBS650204 Unit / Price 0.025 mg / $810 +1 FREE 8GB USB 5x0.025 mg / $3,480 +4 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name Fibroblast growth factor 21, Recombinant Protein Full Product Name Fibroblast growth factor 21, Recombinant, Human (FGF-21) Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Host E Coli Purity/Purification Purified> 97%, as determined by SDS-PAGE and visualized by silver stain. Endotoxin: < 1.0 EU per 1ug of the protein as determined by the LAL method. Form/Format Supplied as a lyophilized powder from 10mM MES, 50mM sodium sulfate, 0.2mM EDTA and Preparation and Storage -20 degree C/-70 degree C Other Notes Small volumes of Fibroblast growth factor 21 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for Fibroblast growth factor 21 recombinant protein Human FGF-21 Fibroblast growth factor 21 (FGF-21) is a member of the FGF gene family, which currently contains 22 human members. Based on its structure, it is further classified as an FGF19 subfamily member. This subfamily includes FGF-19, -21, and -23. Like all other FGF subfamilies, FGF-19 subfamily members contain a 120 amino acid (aa) core FGF domain that exhibits a b-trefoil structure (1, 2). Unlike other FGF subfamilies, FGF-19 subfamily members apparently exhibit poor binding to ECM, resulting in highly diffusible molecules (3). The c-DNA for FGF-21 predicts a 209 aa polypeptide that contains a 28 aa signal sequence and a 181 aa mature region (4). Notably, FGF-21, as well as FGF-19 shows limited binding to heparin (4). One potential alternate splice form has been reported. It shows a 43 aa substitution for the C-terminal 12 aa of the standard form (5). Mature human FGF-21 shows 81% aa identity to mouse FGF-21, and is known to be active on mouse cells (4, 6). The FGF-19 subfamily is considered endocrine in nature. All three subfamily members impact some aspect of metabolism, all three are induced by a nuclear receptor heterodimer that includes RXR, and all three utilize Klotho family members for signal transduction (7, 8, 9). FGF-21 is produced by hepatocytes in response to free fatty acid (FFA) stimulation of a PPARa/RXR dimeric complex. This situation occurs clinically during starvation, or following the ingestion of a high-fat/low-carbohydrate diet. Upon FGF-21 secretion, white adipose tissue is induced to release FFAs from triglyceride stores. Once FFAs reach hepatocytes, they are oxidized and reduced to acetyl-CoA. The acetyl-CoA is recombined into 4-carbon ketone bodies (acetoacetate and b-hydroxybutyrate), released, and transported to peripheral tissues for TCA processing and energy generation. Recombinant human FGF-21 consists of amino acids encompassing His29-Ser209, with an N-terminal 5-His tag (Accession # Q9NSA1). It has a predicted molecular mass of approximately 20.2kD. Product Categories/Family for Fibroblast growth factor 21 recombinant protein Growth Factors; Cytokines; Growth Factors-FGF SDS-Page of Fibroblast growth factor 21 recombinant protein 1ug/lane of Recombinant Human FGF-21 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 24kD. TOP NCBI/Uniprot data below describe general gene information for Fibroblast growth factor 21. It may not necessarily be applicable to this product. NCBI GI # 114731554 TOP NCBI Official Full Name fibroblast growth factor 21 Protein Family Fibroblast growth factor TOP NCBI Summary for Fibroblast growth factor 21 The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined. [provided by RefSeq, Jul 2008] TOP UniProt Comments for Fibroblast growth factor 21 FGF21: Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Belongs to the heparin-binding growth factors family.Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 19q13.33Cellular Component: extracellular regionMolecular Function: protein binding; growth factor activity; fibroblast growth factor receptor bindingBiological Process: positive regulation of glucose import; cell-cell signaling; positive regulation of cell proliferation; positive regulation of low-density lipoprotein receptor biosynthetic process; signal transduction Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with Fibroblast growth factor 21 recombinant protein Reference Product PubMed Publications FLNA recombinant protein >12 publications with Fibroblast growth factor 21 and FLNA Pathways associated with Fibroblast growth factor 21 recombinant protein Products by Pathway Pathway Diagram Focal Adhesion Pathway antibodies Focal Adhesion Pathway Diagram Focal Adhesion Pathway antibodies Focal Adhesion Pathway Diagram MAPK Signaling Pathway antibodies MAPK Signaling Pathway Diagram MAPK Signaling Pathway antibodies MAPK Signaling Pathway Diagram Salmonella Infection Pathway antibodies Salmonella Infection Pathway Diagram Salmonella Infection Pathway antibodies Salmonella Infection Pathway Diagram Organs/Tissues associated with Fibroblast growth factor 21 recombinant protein Organ/Tissue Name Pubmed Publications Bone Antibodies >13 publications with Fibroblast growth factor 21 and Bone Connective Tissue Antibodies >4 publications with Fibroblast growth factor 21 and Connective Tissue Heart Antibodies >3 publications with Fibroblast growth factor 21 and Heart Muscle Antibodies >3 publications with Fibroblast growth factor 21 and Muscle Brain Antibodies >3 publications with Fibroblast growth factor 21 and Brain Vascular Antibodies >2 publications with Fibroblast growth factor 21 and Vascular Embryonic Tissue Antibodies >2 publications with Fibroblast growth factor 21 and Embryonic Tissue Ear Antibodies >1 publications with Fibroblast growth factor 21 and Ear Kidney Antibodies >1 publications with Fibroblast growth factor 21 and Kidney Umbilical Cord Antibodies >1 publications with Fibroblast growth factor 21 and Umbilical Cord TOP