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FGF7 recombinant protein :: Fibroblast growth factor 7 protein (FGF7) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS969360
SDS-PAGE
Unit / Price
0.002 mg  /  $115 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $720 +1 FREE 8GB USB
0.25 mg  /  $1,230 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fibroblast growth factor 7 protein (FGF7), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Fibroblast growth factor 7 protein (FGF7) (Active)

 Product Synonym Names    FGF-7; HBGF-7; Keratinocyte growth factor
 Product Gene Name   

FGF7 recombinant protein

[Similar Products]
 Product Synonym Gene Name    KGF [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    32-194aa, Full Length of Mature Protein
 Sequence    CNDMTPEQMA TNVNCSSPER HTRSYDYMEG GDIRVRRLFC RTQWYLRIDK RGKVKGTQEM KNNYNIMEIR TVAVGIVAIK GVESEFYLAM NKEGKLYAKK ECNEDCNFKE LILENHYNTY ASAKWTHNGG EMFVALNQKG IPVRGKKTKK EQKTAHFLPM AIT
 OMIM    M60828 mRNA
 3D Structure    ModBase 3D Structure for P21781
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 Host    E Coli
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 Purity/Purification    >=96% as determined by SDS-PAGE and HPLC. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
 Biological Activity    Fully biologically active when compared to standard. The ED50 as determined by thymidine uptake assay using FGF-receptors transfected BaF3 cells is less than 10 ng/ml, corresponding to a specific activity of > 1.0 105 IU/mg.
 Storage Buffer    0.2 um filtered 20 mM PB, 0.5 M NaCl, pH 8.0,lyophilized
 Endotoxin    Less than 1.0 EU/ug as determined by LAL method.
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 Preparation and Storage    Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of FGF7 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for FGF7 recombinant protein

   Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation. {ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:8663044}.
 Product Categories/Family for FGF7 recombinant protein    Biological Active Protein; Cancer; Growth Factor
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 SDS-PAGE of FGF7 recombinant protein    FGF7 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for FGF7. It may not necessarily be applicable to this product.
 NCBI GI #    4503705
 NCBI GeneID    2252
 NCBI Accession #    NP_002000.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002009.3 [Other Products]
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 UniProt Primary Accession #    P21781 [Other Products]
 UniProt Secondary Accession #    Q6FGV5; Q96FG5; H0YNY5 [Other Products]
 UniProt Related Accession #    P21781 [Other Products]
 Molecular Weight    18.9 kDa
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 NCBI Official Full Name    fibroblast growth factor 7
 NCBI Official Synonym Full Names    fibroblast growth factor 7
 NCBI Official Symbol    FGF7 [Similar Products]
 NCBI Official Synonym Symbols   
KGF; HBGF-7
[Similar Products]
 NCBI Protein Information    fibroblast growth factor 7
 UniProt Protein Name    Fibroblast growth factor 7
 UniProt Synonym Protein Names   
Heparin-binding growth factor 7; HBGF-7; Keratinocyte growth factor
 Protein Family    Fibroblast growth factor
 UniProt Gene Name    FGF7 [Similar Products]
 UniProt Synonym Gene Names    KGF; FGF-7; HBGF-7 [Similar Products]
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 NCBI Summary for FGF7    The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FGF7    FGF7: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation. Belongs to the heparin-binding growth factors family.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 15q21.2

Cellular Component: extracellular region

Molecular Function: 1-phosphatidylinositol-3-kinase activity; chemoattractant activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity

Biological Process: actin cytoskeleton reorganization; epidermis development; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; mesenchymal cell proliferation; phosphoinositide-mediated signaling; positive chemotaxis; positive regulation of cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of keratinocyte migration; positive regulation of peptidyl-tyrosine phosphorylation; regulation of phosphoinositide 3-kinase cascade; response to wounding
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 Research Articles on FGF7    1. The stability and activity of rhKGF mutants were analyzed using GROMACS molecular dynamics (MD) simulations and docking tools, respectively. The results showed that N159S (N105S in rhKGF sequence) and I172V (I118V in rhKGF) substitutions caused an increased stability and affinity of the rhKGF to Fibroblast growth factor receptor 2 (FGFR2).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FGF7 recombinant proteinPathways associated with FGF7 recombinant protein
 Reference Product  PubMed Publications
 FGFR2 recombinant protein  >268 publications with FGF7 and FGFR2
 FGF2 recombinant protein  >139 publications with FGF7 and FGF2
 FGF1 recombinant protein  >100 publications with FGF7 and FGF1
 FGFR1 recombinant protein  >64 publications with FGF7 and FGFR1
 FGFR3 recombinant protein  >26 publications with FGF7 and FGFR3
 FGFR4 recombinant protein  >18 publications with FGF7 and FGFR4
 SHH recombinant protein  >17 publications with FGF7 and SHH
 EGFR recombinant protein  >15 publications with FGF7 and EGFR
 FGF6 recombinant protein  >12 publications with FGF7 and FGF6
 FGFBP1 recombinant protein  >2 publications with FGF7 and FGFBP1
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activated Point Mutants Of FGFR2 Pathway antibodies  Activated Point Mutants Of FGFR2 Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Constitutive Signaling By Aberrant PI3K In Cancer Pathway antibodies  Constitutive Signaling By Aberrant PI3K In Cancer Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
Diseases associated with FGF7 recombinant proteinOrgans/Tissues associated with FGF7 recombinant protein
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >80 publications with FGF7 and Carcinoma
 Lung Injury Antibodies  >66 publications with FGF7 and Lung Injury
 Hyperplasia Antibodies  >65 publications with FGF7 and Hyperplasia
 Lung Diseases Antibodies  >64 publications with FGF7 and Lung Diseases
 Inflammation Antibodies  >52 publications with FGF7 and Inflammation
 Fibrosis Antibodies  >40 publications with FGF7 and Fibrosis
 Necrosis Antibodies  >36 publications with FGF7 and Necrosis
 Prostatic Hyperplasia Antibodies  >27 publications with FGF7 and Prostatic Hyperplasia
 Breast Neoplasms Antibodies  >25 publications with FGF7 and Breast Neoplasms
 Pulmonary Fibrosis Antibodies  >22 publications with FGF7 and Pulmonary Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >178 publications with FGF7 and Lung
 Skin Antibodies  >169 publications with FGF7 and Skin
 Embryonic Tissue Antibodies  >118 publications with FGF7 and Embryonic Tissue
 Bone Antibodies  >76 publications with FGF7 and Bone
 Prostate Antibodies  >74 publications with FGF7 and Prostate
 Intestine Antibodies  >72 publications with FGF7 and Intestine
 Vascular Antibodies  >57 publications with FGF7 and Vascular
 Kidney Antibodies  >46 publications with FGF7 and Kidney
 Muscle Antibodies  >39 publications with FGF7 and Muscle
 Liver Antibodies  >38 publications with FGF7 and Liver
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