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FBLN1 recombinant protein :: Fibulin 1 (FBLN1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2010143 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
SDS-PAGE
Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $260 +1 FREE 8GB USB
0.1 mg  /  $395 +1 FREE 8GB USB
0.2 mg  /  $485 +1 FREE 8GB USB
0.5 mg  /  $945 +1 FREE 8GB USB
1 mg  /  $1,395 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fibulin 1 (FBLN1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Fibulin 1 (FBLN1)

 Product Gene Name   

FBLN1 recombinant protein

[Similar Products]
 Matching Pairs    Antibody: Fibulin 1 (FBLN1) (MBS2006933)
Antigen: Fibulin 1 (FBLN1) (MBS2010143)
 Matching Pairs    Antibody: Fibulin 1 (FBLN1) (MBS2085940)
Antigen: Fibulin 1 (FBLN1) (MBS2010143)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The sequence of the target protein is listed below. LNDRC RGGGPCKQQC RDTGDEVVCS CFVGYQLLSD GVSCEDVNEC ITGSHSCRLG ESCINTVGSF RCQRDSSCGT GYELTEDNSC KDIDECESGI HNCLPDFICQ NTLGSFRCRP KLQCKSGFIQ DALGNCIDIN ECLSISAPCP IGHTCINTEG SYTCQKNVPN CGRGYHLNEE GTRCVDVDEC APPAEPCGKG HRCVNSPGSF RCECKTGYYF DGISRMCV
 Chromosome Location    Chromosome: 22; NC_000022.10 (45898719..45997014). Location: 22q13.31
 OMIM    135820
 3D Structure    ModBase 3D Structure for P23142
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 Host    E Coli
 Species Reactivity    Homo sapiens (Human)
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 Purity/Purification    > 95%
 Form/Format    Supplied as lyophilized form in 10mM PBS, pH7.4, containing 1mM DTT, 5% trehalose, 0.01% sarcosyl and preservative.
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 Residues    Asp399~Ile578 (Accession # P23142) with N-terminal His-Tag
 Subcellular Location    Secreted, extracellular space, extracellular matrix
 Endotoxin Level    <1.0EU per 1ug (determined by the LAL method)
 Predicted isoelectric point    5.4
 Predicted Molecular Mass    25.7kDa
  Accurate Molecular Mass    30kDa as determined by SDS-PAGE reducing conditions.
 Reconstitution    Reconstitute in sterile ddH2O.
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of FBLN1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for FBLN1 recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-PAGE of FBLN1 recombinant protein    FBLN1 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for FBLN1. It may not necessarily be applicable to this product.
 NCBI GI #    34734062
 NCBI GeneID    2192
 NCBI Accession #    NP_001987.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001996.3 [Other Products]
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 UniProt Primary Accession #    P23142 [Other Products]
 UniProt Secondary Accession #    P23143; P23144; P37888; Q5TIC4; Q8TBH8; Q9HBQ5; Q9UC21; Q9UGR4; Q9UH41; B0QY42 [Other Products]
 UniProt Related Accession #    P23142 [Other Products]
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 NCBI Official Full Name    fibulin-1 isoform C
 NCBI Official Synonym Full Names    fibulin 1
 NCBI Official Symbol    FBLN1 [Similar Products]
 NCBI Official Synonym Symbols   
FBLN; FIBL1
[Similar Products]
 NCBI Protein Information    fibulin-1
 UniProt Protein Name    Fibulin-1
 UniProt Gene Name    FBLN1 [Similar Products]
 UniProt Synonym Gene Names    FIBL-1 [Similar Products]
 UniProt Entry Name    FBLN1_HUMAN
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 NCBI Summary for FBLN1    Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3' end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FBLN1    FBLN1: Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP. A chromosomal aberration involving FBLN1 is found in a complex type of synpolydactyly referred to as 3/3-prime/4 synpolydactyly associated with metacarpal and metatarsal synostoses. Reciprocal translocation t(12;22)(p11.2;q13.3) with C12orf2. Fibroblasts derived from a patient with synpolydactyly displayed alterations in the level of isoform D splice variant incorporated into the ECM and secreted into the conditioned culture medium. By contrast, the expression of isoform C was not perturbed in the patients fibroblasts. Furthermore, no aberrant polypeptides were detected in extracts of cultured patients fibroblasts. The translocation t(12;22) may result in haploinsufficiency of the isoform D splice variant, which could lead to the observed limb malformation. Elevated expression and altered processing of FBLN1 protein is associated with human breast cancer. Belongs to the fibulin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Extracellular matrix; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; extracellular region; basement membrane

Molecular Function: protease activator activity; extracellular matrix structural constituent; calcium ion binding

Biological Process: extracellular matrix organization and biogenesis; viral reproduction; embryo implantation

Disease: Synpolydactyly 2
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 Research Articles on FBLN1    1. Increased plasma fibulin-1 levels are associated with diabetes and impaired kidney function.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with FBLN1 recombinant proteinDiseases associated with FBLN1 recombinant protein
 Products by Pathway  Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Molecules Associated With Elastic Fibres Pathway antibodies  Molecules Associated With Elastic Fibres Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >11 publications with FBLN1 and Neoplasms
 Carcinoma Antibodies  >7 publications with FBLN1 and Carcinoma
 Prostatic Neoplasms Antibodies  >4 publications with FBLN1 and Prostatic Neoplasms
 Adenocarcinoma Antibodies  >3 publications with FBLN1 and Adenocarcinoma
 Kidney Diseases Antibodies  >2 publications with FBLN1 and Kidney Diseases
 Synpolydactyly 2 Antibodies  >2 publications with FBLN1 and Synpolydactyly 2
 Neoplasms, Experimental Antibodies  >2 publications with FBLN1 and Neoplasms, Experimental
 Proteinuria Antibodies  >1 publications with FBLN1 and Proteinuria
 Liver Diseases Antibodies  >1 publications with FBLN1 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with FBLN1 and Carcinoma, Hepatocellular
Organs/Tissues associated with FBLN1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with FBLN1 and Blood
 Eye Antibodies  >5 publications with FBLN1 and Eye
 Embryonic Tissue Antibodies  >4 publications with FBLN1 and Embryonic Tissue
 Prostate Antibodies  >4 publications with FBLN1 and Prostate
 Bone Antibodies  >3 publications with FBLN1 and Bone
 Skin Antibodies  >3 publications with FBLN1 and Skin
 Heart Antibodies  >2 publications with FBLN1 and Heart
 Uterus Antibodies  >2 publications with FBLN1 and Uterus
 Uncharacterized Tissue Antibodies  >2 publications with FBLN1 and Uncharacterized Tissue
 Nerve Antibodies  >2 publications with FBLN1 and Nerve
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