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FBLN5 recombinant protein :: Fibulin 5 (FBLN5) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2011471 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment) FBLN5 recombinant protein
Unit / Price
0.01 mg  /  $190 +1 FREE 8GB USB
0.05 mg  /  $405 +1 FREE 8GB USB
0.1 mg  /  $625 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fibulin 5 (FBLN5), Recombinant Protein

 Also Known As   

Recombinant Fibulin 5 (FBLN5)

 Product Gene Name   

FBLN5 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with N-terminal His-Tag, its sequence is listed below.
MGHHHHHHSG SEF-IGENRC MCPA EHTSCRDQPF TILYRDMDVV SGRSVPADIF QMQATTRYPG AYYIFQIKSG NEGREFYMRQ TGPISATLVM TRPIKGPRDI QLDLEMITVN TVINFRGSSV IRLRIYVSQY PF
 Chromosome Location    Chromosome: 12; NC_000078.6 (101746565..101819130, complement). Location: 12; 12 F1
 3D Structure    ModBase 3D Structure for Q9WVH9
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 Host    E Coli
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 Purity/Purification    > 95%
 Form/Format    Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
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 Organism    Mus musculus (Mouse)
 Expression System    Prokaryotic expression
 Residues    Ile327~Phe448 (Accession # Q9WVH9) with N-terminal His-Tag
 Endotoxin Level    <1.0EU per 1ug (determined by the LAL method)
 Reconstitution    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of FBLN5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for FBLN5 recombinant protein

   About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
 Applications Tested/Suitable for FBLN5 recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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NCBI/Uniprot data below describe general gene information for FBLN5. It may not necessarily be applicable to this product.
 NCBI GI #    6753824
 NCBI GeneID    23876
 NCBI Accession #    NP_035942.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_011812.4 [Other Products]
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 UniProt Primary Accession #    Q9WVH9 [Other Products]
 UniProt Secondary Accession #    Q541Z7 [Other Products]
 UniProt Related Accession #    Q9WVH9 [Other Products]
 Molecular Weight    15.5kDa
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 NCBI Official Full Name    fibulin-5
 NCBI Official Synonym Full Names    fibulin 5
 NCBI Official Symbol    Fbln5 [Similar Products]
 NCBI Official Synonym Symbols   
A55; EVEC; DANCE
[Similar Products]
 NCBI Protein Information    fibulin-5; FIBL-5; developmental arteries and neural crest EGF-like protein
 UniProt Protein Name    Fibulin-5
 UniProt Synonym Protein Names   
Developmental arteries and neural crest EGF-like protein
 Protein Family    Fibulin
 UniProt Gene Name    Fbln5 [Similar Products]
 UniProt Synonym Gene Names    Dance; FIBL-5; Dance [Similar Products]
 UniProt Entry Name    FBLN5_MOUSE
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 UniProt Comments for FBLN5    FBLN5: Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling. Defects in FBLN5 are the cause of cutis laxa, autosomal dominant, type 2 (ADCL2). A connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. Additional variable clinical features are gastrointestinal diverticula, hernia, and genital prolapse. Rare manifestations are pulmonary artery stenosis, aortic aneurysm, bronchiectasis, and emphysema. Defects in FBLN5 are a cause of cutis laxa, autosomal recessive, type 1A (ARCL1A). A connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. The clinical spectrum of autosomal recessive cutis laxa is highly heterogeneous with respect to organ involvement and severity. Type I autosomal recessive cutis laxa is a specific, life-threatening disorder with organ involvement, lung atelectasis and emphysema, diverticula of the gastrointestinal and genitourinary systems, and vascular anomalies. Associated cranial anomalies, late closure of the fontanel, joint laxity, hip dislocation, and inguinal hernia have been observed but are uncommon. Defects in FBLN5 are the cause of age-related macular degeneration type 3 (ARMD3). ARMD is a multifactorial disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid (known as drusen) that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Belongs to the fibulin family.

Protein type: Secreted, signal peptide; Secreted

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; extracellular region

Molecular Function: integrin binding; protein C-terminus binding; protein homodimerization activity; calcium ion binding

Biological Process: elastic fiber assembly; extracellular matrix organization and biogenesis; secretion; cell adhesion
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 Research Articles on FBLN5    1. Without LTBP-4, fibulin-5 and tropoelastin deposition was discontinuous and punctate in vitro and in vivo
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with FBLN5 recombinant proteinDiseases associated with FBLN5 recombinant protein
 Products by Pathway  Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Molecules Associated With Elastic Fibres Pathway antibodies  Molecules Associated With Elastic Fibres Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >16 publications with FBLN5 and Cardiovascular Diseases
 Vascular Diseases Antibodies  >11 publications with FBLN5 and Vascular Diseases
 Heart Diseases Antibodies  >9 publications with FBLN5 and Heart Diseases
 Disease Models, Animal Antibodies  >8 publications with FBLN5 and Disease Models, Animal
 Nervous System Diseases Antibodies  >6 publications with FBLN5 and Nervous System Diseases
 Emphysema Antibodies  >5 publications with FBLN5 and Emphysema
 Inflammation Antibodies  >3 publications with FBLN5 and Inflammation
 Macular Degeneration, Age-Related, 3 Antibodies  >2 publications with FBLN5 and Macular Degeneration, Age-Related, 3
 CUTIS LAXA, AUTOSOMAL DOMINANT 1 Antibodies  >2 publications with FBLN5 and CUTIS LAXA, AUTOSOMAL DOMINANT 1
 Uterine Cervical Neoplasms Antibodies  >2 publications with FBLN5 and Uterine Cervical Neoplasms
Organs/Tissues associated with FBLN5 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >41 publications with FBLN5 and Skin
 Lung Antibodies  >18 publications with FBLN5 and Lung
 Heart Antibodies  >10 publications with FBLN5 and Heart
 Vagina Antibodies  >10 publications with FBLN5 and Vagina
 Embryonic Tissue Antibodies  >10 publications with FBLN5 and Embryonic Tissue
 Bone Antibodies  >7 publications with FBLN5 and Bone
 Kidney Antibodies  >6 publications with FBLN5 and Kidney
 Eye Antibodies  >6 publications with FBLN5 and Eye
 Brain Antibodies  >5 publications with FBLN5 and Brain
 Ovary Antibodies  >3 publications with FBLN5 and Ovary
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