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FCN3 recombinant protein :: Ficolin 3 (FCN3) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2009080 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $115 +1 FREE 8GB USB
0.05 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $295 +1 FREE 8GB USB
0.2 mg  /  $370 +1 FREE 8GB USB
0.5 mg  /  $710 +1 FREE 8GB USB
1 mg  /  $1,050 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ficolin 3 (FCN3), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Ficolin 3 (FCN3)

 Product Gene Name   

FCN3 recombinant protein

[Similar Products]
 Matching Pairs    Antibody: Ficolin 3 (FCN3) (MBS2003967)
Antigen: Ficolin 3 (FCN3) (MBS2009080)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (27695601..27701315, complement). Location: 1p36.11
 OMIM    604973
 3D Structure    ModBase 3D Structure for O75636
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 Host    E. coli
 Species Reactivity    Homo sapiens (Human)
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 Purity/Purification    >97%
 Form/Format    20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300
 Concentration    200ug/mL (lot specific)
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 Source    Prokaryotic expression
 Residues    Glu34~Met297
 Tags    N-terminal His-Tag
 Tissue Specificity    Liver, Lung, Heart, Brain, Kidney
 Subcellular Location    Secreted
 Traits    Freeze-dried powder
 Predicted isoelectric point    6.3
 Predicted Molecular Mass    30.2kDa
 Accurate Molecular Mass    31kDa as determined by SDS-PAGE reducing conditions
 Usage    Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8 degree C for one month.
Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of FCN3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for FCN3 recombinant protein   

Positive Control, Immunogen, SDS-PAGE, WB.

(May be suitable for use in other assays to be determined by the end user.)

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 Sequence of FCN3 recombinant protein    FCN3 recombinant protein Sequence image
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 SDS-PAGE of FCN3 recombinant protein    FCN3 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for FCN3. It may not necessarily be applicable to this product.
 NCBI GI #    27754776
 NCBI GeneID    8547
 NCBI Accession #    NP_003656.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003665.2 [Other Products]
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 UniProt Primary Accession #    O75636 [Other Products]
 UniProt Secondary Accession #    Q6IBJ5; Q8WW86 [Other Products]
 UniProt Related Accession #    O75636 [Other Products]
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 NCBI Official Full Name    ficolin-3 isoform 1
 NCBI Official Synonym Full Names    ficolin (collagen/fibrinogen domain containing) 3
 NCBI Official Symbol    FCN3 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    ficolin-3; H-ficolin; ficolin 3; collagen/fibrinogen domain-containing protein 3; collagen/fibrinogen domain-containing lectin 3 p35; ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)
 UniProt Protein Name    Ficolin-3
 UniProt Synonym Protein Names   
Collagen/fibrinogen domain-containing lectin 3 p35; Collagen/fibrinogen domain-containing protein 3; Hakata antigen
 Protein Family    Ficolin
 UniProt Gene Name    FCN3 [Similar Products]
 UniProt Synonym Gene Names    FCNH; HAKA1 [Similar Products]
 UniProt Entry Name    FCN3_HUMAN
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 NCBI Summary for FCN3    Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FCN3    FCN3: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota. Defects in FCN3 are the cause of ficolin 3 deficiency (FCN3D). FCN3D is a disorder characterized by immunodeficiency, recurrent infections, brain abscesses and recurrent warts on the fingers. Affected individuals have normal levels of lymphocytes, normal T-cell responses, and normal antibodies, but a selective deficient antibody response to pneumococcal polysaccharide vaccine. Belongs to the ficolin lectin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: collagen; extracellular region

Molecular Function: protein binding; carbohydrate binding; antigen binding

Biological Process: negative regulation of virion penetration into host cell; innate immune response; complement activation, lectin pathway; recognition of apoptotic cell; defense response to virus; complement activation

Disease: Immunodeficiency Due To Ficolin 3 Deficiency
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 Research Articles on FCN3    1. Data show that the expression of ficolin-3(FCN3) in ovarian cancer (OC) was inversely correlated with serum ficolin-3 and lower in comparison with controls.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FCN3 recombinant proteinPathways associated with FCN3 recombinant protein
 Reference Product  PubMed Publications
 MASP2 recombinant protein  >11 publications with FCN3 and MASP2
 MASP1 recombinant protein  >8 publications with FCN3 and MASP1
 MBL2 recombinant protein  >4 publications with FCN3 and MBL2
 C1R recombinant protein  >1 publications with FCN3 and C1R
 C1S recombinant protein  >1 publications with FCN3 and C1S
 Products by Pathway  Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Creation Of C4 And C2 Activators Pathway antibodies  Creation Of C4 And C2 Activators Pathway Diagram
 Ficolins Bind To Repetitive Carbohydrate Structures On The Target Cell Surface Pathway antibodies  Ficolins Bind To Repetitive Carbohydrate Structures On The Target Cell Surface Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Initial Triggering Of Complement Pathway antibodies  Initial Triggering Of Complement Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Lectin Pathway Of Complement Activation antibodies  Lectin Pathway Of Complement Activation Diagram
Diseases associated with FCN3 recombinant proteinOrgans/Tissues associated with FCN3 recombinant protein
 Disease Name  Pubmed Publications
 Immunologic Deficiency Syndromes Antibodies  >1 publications with FCN3 and Immunologic Deficiency Syndromes
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >31 publications with FCN3 and Blood
 Liver Antibodies  >5 publications with FCN3 and Liver
 Lung Antibodies  >4 publications with FCN3 and Lung
 Kidney Antibodies  >2 publications with FCN3 and Kidney
 Intestine Antibodies  >1 publications with FCN3 and Intestine
 Placenta Antibodies  >1 publications with FCN3 and Placenta
 Eye Antibodies  >1 publications with FCN3 and Eye
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