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FLT3LG recombinant protein :: Flt3-Ligand Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143664 FLT3LG recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $1,125 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Flt3-Ligand (FLT3LG), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Flt3-Ligand, HEK

 Product Synonym Names    Flt3 Ligand Human, HEK; Flt3-Ligand Human Recombinant, HEK derived; Fms-related tyrosine kinase 3 ligand; FLK2; STK1; CD135; Stem Cell Tyrosine Kinase 1; FLT3LG; Flt3; Flt3 Ligand HEK
 Product Gene Name   

FLT3LG recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    TQDCSFQHSP ISSDFAVKIR ELSDYLLQDY PVTVASNLQD EELCGGLWRL VLAQRWMERL KTVAGSKMQG LLERVNTEIH FVTKCAFQPP PSCLRFVQTN ISRLLQETSE QLVALKPWIT RQNFSRCLEL QCQPDSSTLP PPWSPRPLEA TAPTAPQP
 OMIM    600007
 3D Structure    ModBase 3D Structure for P49771
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 Host    HEK293 (Human Embryonic Kidney cell line)
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 Purity/Purification    Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
 Form/Format    The protein was lyophilized with no additives.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized Flt3-Ligand in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
 Biological Activity    The ED50 as determined by the dose dependent proliferation of human OCI-AML5 cells is 0.5 to 1.0 ng/ml (Specific Activity: 2.0 x 1,000,000 1.0 x 1,000,000 units/mg).
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 Preparation and Storage    Lyophilized Flt3-Ligand although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution Flt3-Ligand should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of FLT3LG recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for FLT3LG recombinant protein

   Description: Flt3-Ligand Human Recombinant produced in HEK293 cells is a glycosylated, polypeptide chain, migrates as a diffuse band on SDS-PAGE due to heterogeneous glycosylation at 30kDa. Flt3-Ligand is purified by proprietary chromatographic techniques.

Introduction: FLT3 ligand is a receptor for the fl cytokine has a tyrosine-protein kinase activity & a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand synergizes with other CSFs and interleukins to induce growth and differentiation.
 Product Categories/Family for FLT3LG recombinant protein    CYTOKINES AND GROWTH FACTORS; Cytokines; Flt3 Ligand
NCBI/Uniprot data below describe general gene information for FLT3LG. It may not necessarily be applicable to this product.
 NCBI GI #    325197197
 NCBI GeneID    2323
 NCBI Accession #    NP_001191431.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001204502.1 [Other Products]
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 UniProt Primary Accession #    P49771 [Other Products]
 UniProt Secondary Accession #    Q05C96; A0AVC2; B9EGH2 [Other Products]
 UniProt Related Accession #    P49771 [Other Products]
 Molecular Weight    17,290 Da [Similar Products]
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 NCBI Official Full Name    fms-related tyrosine kinase 3 ligand isoform 1
 NCBI Official Synonym Full Names    fms-related tyrosine kinase 3 ligand
 NCBI Official Symbol    FLT3LG [Similar Products]
 NCBI Official Synonym Symbols   
FL; FLT3L
[Similar Products]
 NCBI Protein Information    fms-related tyrosine kinase 3 ligand; flt3 ligand
 UniProt Protein Name    Fms-related tyrosine kinase 3 ligand
 UniProt Synonym Protein Names   
SL cytokine
 Protein Family    Fms-related tyrosine kinase
 UniProt Gene Name    FLT3LG [Similar Products]
 UniProt Synonym Gene Names    Flt3 ligand; Flt3L [Similar Products]
 UniProt Entry Name    FLT3L_HUMAN
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 NCBI Summary for FLT3LG    Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]
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 UniProt Comments for FLT3LG    FLT3LG: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Ligand, receptor tyrosine kinase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: extracellular space; membrane; integral to membrane

Molecular Function: protein homodimerization activity; cytokine activity; receptor tyrosine kinase binding; receptor binding

Biological Process: regulation of myeloid dendritic cell activation; positive regulation of natural killer cell differentiation; lymphocyte differentiation; embryonic hemopoiesis; positive regulation of cell proliferation; positive regulation of protein amino acid phosphorylation; signal transduction; positive regulation of myoblast differentiation
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 Research Articles on FLT3LG    1. The immunohistochemical expression of caveolin-1 and podocalyxin in lungs from rats challenged with a 2-kDa macrophage-activating lipopeptide (MALP-2) and Flt3L, was examined.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FLT3LG recombinant proteinPathways associated with FLT3LG recombinant protein
 Reference Product  PubMed Publications
 FLT3 recombinant protein  >6 publications with FLT3LG and FLT3
 KITLG recombinant protein  >4 publications with FLT3LG and KITLG
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
Diseases associated with FLT3LG recombinant proteinOrgans/Tissues associated with FLT3LG recombinant protein
 Disease Name  Pubmed Publications
 Leukemia Antibodies  >2 publications with FLT3LG and Leukemia
 Lymphoma Antibodies  >1 publications with FLT3LG and Lymphoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with FLT3LG and Blood
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