NP_990766.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
focal adhesion kinase 1
NCBI Official Synonym Full Names
protein tyrosine kinase 2
NCBI Protein Information
focal adhesion kinase 1
UniProt Protein Name
Focal adhesion kinase 1
UniProt Synonym Protein Names
Focal adhesion kinase-related nonkinase; FRNK; p41/p43FRNK; Protein-tyrosine kinase 2; p125FAK; pp125FAK
UniProt Synonym Gene Names
UniProt Comments for FAK1
FAK: a tyrosine kinase of the FAK family required for cell migration and contact-dependent survival signaling. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Downstream of integrins and Src, upstream of Ras/MAPK. Localizes to focal adhesions that form between cells growing in the presence of extracellular matrix constituents. Interacts with CAS family members and with GIT1, SORBS1 and BCAR3. Interacts with Shb. Required for full Ras transformation of fibroblasts. Increased expression in breast and other cancers, related to chromosome 8q amplification. Overexpression and activation associated with increased migration, invasion and progression of ovarian cancer, and with progression in hepatocellular carcinoma, thyroid cancer, and acute myelogenous leukemia. siRNA increases chemosensitivity of pancreatic adenocarcinoma xenografts. Inhibitor: ISI15421 (antisense). Four splice-variant isoforms have been observed.
Protein type: EC 2.7.10.2; Fak family; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Cellular Component: cell; cytoplasm; extrinsic to internal side of plasma membrane; focal adhesion; sarcolemma
Molecular Function: calcium-dependent cysteine-type endopeptidase activity; identical protein binding; non-membrane spanning protein tyrosine kinase activity; protease binding; protein binding; protein-tyrosine kinase activity; receptor binding
Biological Process: actin filament organization; angiogenesis involved in wound healing; epidermal growth factor receptor signaling pathway; innate immune response; negative regulation of protein amino acid autophosphorylation; positive regulation of cell proliferation; positive regulation of focal adhesion formation; positive regulation of protein binding; protein amino acid autophosphorylation; pyramidal neuron migration; response to pH
Research Articles on FAK1
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Products associated with FAK1 recombinant protein
Pathways associated with FAK1 recombinant protein
Diseases associated with FAK1 recombinant protein
Organs/Tissues associated with FAK1 recombinant protein
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