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FST recombinant protein :: Follistatin Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS553343 FST recombinant protein
Unit / Price
0.002 mg  /  $145 +1 FREE 8GB USB
0.01 mg  /  $220 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Follistatin (FST), Recombinant Protein

★Popular Item★
 Also Known As   

Human Follistatin Recombinant

 Product Synonym Names    fst; follicle; follistatin
 Product Gene Name   

FST recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    136470
 3D Structure    ModBase 3D Structure for P19883
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 Host    HEk293 Cells
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 Purity/Purification    >95%, as determined by SDS-PAGE and HPLC
 Form/Format    Recombinant Human Follistatin was lyophillized at 1mg/ml containing no additives.
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 Domain    Follistatin
 Biological Activity    The ED(50) was determined by the ability to neutralize Activin A inhibitory effect of mouse MPC-11 and was determined to be 0.1-0.4 ug/ml in the presence of 7.5 ng/ml Activin A.
 Edotoxin    Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug)
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 Preparation and Storage    Upon reconstitution, this protein can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for 12 months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of FST recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for FST recombinant protein    Cytokines
NCBI/Uniprot data below describe general gene information for FST. It may not necessarily be applicable to this product.
 NCBI GI #    5453652
 NCBI GeneID    10468
 NCBI Accession #    NP_006341.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006350.3 [Other Products]
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 UniProt Primary Accession #    P19883 [Other Products]
 UniProt Secondary Accession #    Q9BTH0; B5BU94 [Other Products]
 Molecular Weight    Native human Follistatin, generated by the proteolytic removal of the signal peptide and propeptide, the molecule has a calculated molecular mass of approximately 31 kDa. Recombinant Follistatin is a disulfide-linked monomer protein consisting of 296 amin
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 NCBI Official Full Name    follistatin isoform FST317
 UniProt Protein Name    Follistatin
 UniProt Synonym Protein Names   
Activin-binding protein
 Protein Family    Follistatin
 UniProt Gene Name    FST [Similar Products]
 UniProt Synonym Gene Names    FS [Similar Products]
 UniProt Entry Name    FST_HUMAN
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 NCBI Summary for FST    Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FST    FST: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q11.2

Cellular Component: cytoplasm; extracellular region; nucleus

Molecular Function: heparan sulfate proteoglycan binding; signal transducer activity; protein binding; activin binding

Biological Process: BMP signaling pathway; positive regulation of hair follicle development; negative regulation of activin receptor signaling pathway; negative regulation of cell differentiation; hair follicle morphogenesis; gamete generation; hemopoietic progenitor cell differentiation; negative regulation of transcription from RNA polymerase II promoter; keratinocyte proliferation; skeletal development; pattern specification process; female gonad development; odontogenesis of dentine-containing teeth

Disease: Polycystic Ovary Syndrome 1
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Product References and Citations for FST recombinant protein

   structure of myostatin·follistatin-like 3: n-terminal domains of follistatin-type molecules exhibit alternate modes of binding .J. Biol. Chem., Jan 2012; 287: 1043 - 1053.
the type 1 insulin-like growth factor receptor (igf-ir) pathway is mandatory for the follistatin-induced skeletal muscle hypertrophy .Endocrinology, Jan 2012; 153: 241 - 253.
short-term energy deprivation alters activin a and follistatin but not inhibin b levels of lean healthy women in a leptin-independent manner .J. Clin. Endocrinol. Metab., Dec 2011; 96: 3750 - 3758.
the expression of activins, their type ii receptors and follistatin in human fallopian tube during the menstrual cycle and in pseudo-pregnancy .Hum. Reprod., Dec 2011; 26: 3346 - 3354.
energy deprivation alters in a leptin- and cortisol-independent manner circulating levels of activin a and follistatin but not myostatin in healthy males .J. Clin. Endocrinol. Metab., Nov 2011; 96: 3416 - 3423.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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