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Fst recombinant protein :: Follistatin Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS538118 Fst recombinant protein
Unit / Price
0.02 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Follistatin (Fst), Recombinant Protein

★Popular Item★
 Also Known As   

Follistatin protein

 Product Synonym Names    activins-binding protein; FS protein
 Product Gene Name   

Fst recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    Region of Follistati n protein correspond ing to amino acids GNCWLRQAKN GRCQVLYKTE LSKEECCSTG RLSTSWTEED VNDNTLFKWM IFNGGAPNCI PCKETCENVD CGPGKKCRMN KKNKPRCVCA PDCSNITWKG PVCGLDGKTY RNECALLKAR CKEQPELEVQ YQGRCKKTCR DVFCPGSSTC VVDQTNNAYC VTCNRICPEP ASSEQYLCGN DGVTYSSACH LRKATCLLGR SIGLAYEGKC IKAKSCEDIQ CTGGKKCLWD FKVGRGRCSL CDELCPDSKS DEPVCASDNA TYASECAMKE AACSSGVLLE VKHSGSCN.
 3D Structure    ModBase 3D Structure for P47931
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 Host    Human
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 Purity/Purification    > 95% pure
 Form/Format    Lyophilized from 10mM Na3PO4, pH 7.5, with 75mM NaCl. Reconstitute in distilled water to a concentration of 0.1-1.0 mg/ml
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 Protein Type    Recombinant
 Biological Significance    Follistatin is a secreted protein that binds to ligands of the TGF beta family and regulates their activity by inhibiting their access to signaling receptors. It was originally discovered as activin antagonists whose activity suppresses expression and secretion of the pituitary hormone FSH (follicle stimulating hormone). In addition to being a natural antagonist, follistatin can inhibit the activity of other TGF beta ligands including BMP-2, -4, -6, -7, Myostatin, GDF-11, and TGF beta1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues.
 Bioactivity    Determined by its ability to neutralize Activin A inhibitory effect of Mouse MPC-11 cells. The expected ED50 is 0.1-0.4 ug/ml in the presence of 7.5 ng/ml Activin A.
 Endotoxin Levels    Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
 Expression System    E Coli
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 Preparation and Storage    Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of Fst recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Fst recombinant protein

   Purified recombinant Human Follistatin protein
 Product Categories/Family for Fst recombinant protein    Proteases, Inhibitors, & Enzymes
 Applications Tested/Suitable for Fst recombinant protein   

User optimized

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NCBI/Uniprot data below describe general gene information for Fst. It may not necessarily be applicable to this product.
 NCBI GI #    6679867
 NCBI GeneID    14313
 NCBI Accession #    NP_032072.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_008046.2 [Other Products]
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 UniProt Primary Accession #    P47931 [Other Products]
 UniProt Secondary Accession #    A6H6P0 [Other Products]
 UniProt Related Accession #    P47931 [Other Products]
 Molecular Weight    31.5 kDa [Similar Products]
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 NCBI Official Full Name    follistatin isoform 2
 NCBI Official Synonym Full Names    follistatin
 NCBI Official Symbol    Fst [Similar Products]
 NCBI Official Synonym Symbols   
FS; AL033346
[Similar Products]
 NCBI Protein Information    follistatin
 UniProt Protein Name    Follistatin
 UniProt Synonym Protein Names   
Activin-binding protein
 Protein Family    Follistatin
 UniProt Gene Name    Fst [Similar Products]
 UniProt Synonym Gene Names    FS [Similar Products]
 UniProt Entry Name    FST_MOUSE
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 NCBI Summary for Fst    The protein encoded by this gene binds to and negatively regulates activin, as well as other members of the transforming growth factor beta family, and acts to prevent uncontrolled cellular proliferation. This protein also contains a heparin-binding sequence. It is expressed in many of the tissues in which activin is synthesized and is thought to clear activin from the circulation by attachment to the cell surface. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms, including FST315 and FST288, that differ at their C-terminus. Another isoform, FST303 is thought to be produced by proteolytic cleavage of FST315. These isoforms differ in their localization and in their ability to bind heparin. While FST315 is a circulating protein, FST288 is tissue-bound, and FST303 is gonad-specific. While deletion of all isoforms results in embryonic lethality, expression of just FST288 is sufficient for embryonic development, but the resultant mice have fertility defects. [provided by RefSeq, Aug 2014]
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 UniProt Comments for Fst    FST: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH)

Protein type: Secreted; Secreted, signal peptide

Cellular Component: cytoplasm; extracellular region; nucleus

Molecular Function: heparan sulfate proteoglycan binding; activin binding

Biological Process: BMP signaling pathway; positive regulation of hair follicle development; negative regulation of activin receptor signaling pathway; negative regulation of cell differentiation; hair follicle morphogenesis; gamete generation; hemopoietic progenitor cell differentiation; negative regulation of transcription from RNA polymerase II promoter; keratinocyte proliferation; pattern specification process; skeletal development; female gonad development; odontogenesis of dentine-containing teeth
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 Research Articles on Fst    1. Results implicate a role of follistatin (Fst) in the induction of brown adipocyte character and regulation of energy metabolism.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Fst recombinant proteinPathways associated with Fst recombinant protein
 Reference Product  PubMed Publications
 Inhba recombinant protein  >11 publications with Fst and Inhba
 Inhbb recombinant protein  >8 publications with Fst and Inhbb
 Bmp2 recombinant protein  >7 publications with Fst and Bmp2
 Bmp4 recombinant protein  >4 publications with Fst and Bmp4
 Bmp7 recombinant protein  >3 publications with Fst and Bmp7
 Nog recombinant protein  >2 publications with Fst and Nog
 Bmp5 recombinant protein  >2 publications with Fst and Bmp5
 Bmp6 recombinant protein  >1 publications with Fst and Bmp6
 Products by Pathway  Pathway Diagram
 Antagonism Of Activin By Follistatin Pathway antibodies  Antagonism Of Activin By Follistatin Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Activin Pathway antibodies  Signaling By Activin Pathway Diagram
 TGF Beta Signaling Pathway antibodies  TGF Beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
Diseases associated with Fst recombinant proteinOrgans/Tissues associated with Fst recombinant protein
 Disease Name  Pubmed Publications
 Learning Disorders Antibodies  >57 publications with Fst and Learning Disorders
 Inflammation Antibodies  >53 publications with Fst and Inflammation
 Necrosis Antibodies  >44 publications with Fst and Necrosis
 Cardiovascular Diseases Antibodies  >39 publications with Fst and Cardiovascular Diseases
 Cognition Disorders Antibodies  >28 publications with Fst and Cognition Disorders
 Weight Loss Antibodies  >21 publications with Fst and Weight Loss
 Breast Neoplasms Antibodies  >15 publications with Fst and Breast Neoplasms
 Abnormalities, Drug-Induced Antibodies  >13 publications with Fst and Abnormalities, Drug-Induced
 Hypertension Antibodies  >12 publications with Fst and Hypertension
 Prenatal Exposure Delayed Effects Antibodies  >9 publications with Fst and Prenatal Exposure Delayed Effects
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >864 publications with Fst and Brain
 Muscle Antibodies  >80 publications with Fst and Muscle
 Skin Antibodies  >74 publications with Fst and Skin
 Eye Antibodies  >46 publications with Fst and Eye
 Ovary Antibodies  >43 publications with Fst and Ovary
 Embryonic Tissue Antibodies  >19 publications with Fst and Embryonic Tissue
 Lung Antibodies  >16 publications with Fst and Lung
 Spleen Antibodies  >15 publications with Fst and Spleen
 Adipose Tissue Antibodies  >11 publications with Fst and Adipose Tissue
 Thyroid Antibodies  >10 publications with Fst and Thyroid
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