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FOXI1 recombinant protein :: Forkhead box protein I1 (FOXI1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1478917 FOXI1 recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $1,145 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,145 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,375 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,375 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,830 +2 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,830 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,295 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,295 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Forkhead box protein I1 (FOXI1), Recombinant Protein

 Also Known As   

Recombinant Human Forkhead box protein I1 (FOXI1)

 Product Synonym Names    Forkhead box protein I1; Forkhead-related protein FKHL10; Forkhead-related transcription factor 6; FREAC-6; Hepatocyte nuclear factor 3 forkhead homolog 3; HFH-3; HNF-3/fork-head homolog 3
 Product Gene Name   

FOXI1 recombinant protein

[Similar Products]
 Product Synonym Gene Name    FOXI1; FKHL10; FREAC6 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-378
 Sequence    MSSFDLPAPS PPRCSPQFPS IGQEPPEMNL YYENFFHPQG VPSPQRPSFE GGGEYGATPN PYLWFNGPTM TPPPYLPGPN ASPFLPQAYG VQRPLLPSVS GLGGSDLGWL PIPSQEELMK LVRPPYSYSA LIAMAIHGAP DKRLTLSQIY QYVADNFPFY NKSKAGWQNS IRHNLSLNDC FKKVPRDEDD PGKGNYWTLD PNCEKMFDNG NFRRKRKRKS DVSSSTASLA LEKTESSLPV DSPKTTEPQD ILDGASPGGT TSSPEKRPSP PPSGAPCLNS FLSSMTAYVS GGSPTSHPLV TPGLSPEPSD KTGQNSLTFN SFSPLTNLSN HSGGGDWANP MPTNMLSYGG SVLSQFSPHF YNSVNTSGVL YPREGTEV
 OMIM    601093
 3D Structure    ModBase 3D Structure for Q12951
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol; lyophilization may be available upon request.
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information. Additional charge for Tag removal. Tag removal service standardly refers to removal of N-terminal Tag. Any C-terminal Myc-tag may remain intact unless removal of the C-terminal Myc-tag is specifically requested. In most cases tags can be successfully removed. If the lab concludes the protein is no longer stable after tag removal then your protein will be supplied with the tag intact, and you will not be charged for tag removal service.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of FOXI1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for FOXI1. It may not necessarily be applicable to this product.
 NCBI GI #    21618327
 NCBI GeneID    2299
 NCBI Accession #    NP_036320.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_012188.4 [Other Products]
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 UniProt Primary Accession #    Q12951 [Other Products]
 UniProt Secondary Accession #    Q14518; Q66SR7; Q8N6L8 [Other Products]
 UniProt Related Accession #    Q12951 [Other Products]
 Molecular Weight    30,814 Da
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 NCBI Official Full Name    forkhead box protein I1 isoform a
 NCBI Official Synonym Full Names    forkhead box I1
 NCBI Official Symbol    FOXI1 [Similar Products]
 NCBI Official Synonym Symbols   
HFH3; FKH10; HFH-3; FKHL10; FREAC6; FREAC-6
[Similar Products]
 NCBI Protein Information    forkhead box protein I1; forkhead-like 10; HNF-3/fork-head homolog 3; HNF-3/fork-head homolog-3; forkhead-related activator 6; forkhead-related protein FKHL10; forkhead-related transcription factor 6; hepatocyte nuclear factor 3 forkhead homolog 3
 UniProt Protein Name    Forkhead box protein I1
 UniProt Synonym Protein Names   
Forkhead-related protein FKHL10; Forkhead-related transcription factor 6; FREAC-6; Hepatocyte nuclear factor 3 forkhead homolog 3; HFH-3; HNF-3/fork-head homolog 3
 Protein Family    Forkhead box protein
 UniProt Gene Name    FOXI1 [Similar Products]
 UniProt Synonym Gene Names    FKHL10; FREAC6; FREAC-6; HFH-3; HNF-3/fork-head homolog 3 [Similar Products]
 UniProt Entry Name    FOXI1_HUMAN
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 NCBI Summary for FOXI1    This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it is possible that this gene plays an important role in the development of the cochlea and vestibulum, as well as embryogenesis. Mutations in this gene may be associated with the common cavity phenotype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FOXI1    FOXI1: Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 5q34

Cellular Component: nucleus

Molecular Function: sequence-specific DNA binding; transcription factor activity; DNA bending activity

Biological Process: inner ear morphogenesis; embryonic development; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter

Disease: Pendred Syndrome; Deafness, Autosomal Recessive 4, With Enlarged Vestibular Aqueduct
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 Research Articles on FOXI1    1. We found no evidence for a significant association between mutations of KCNJ10 and FOXI1 with SLC26A4 in Pendred syndrome/enlarged vestibular aqueducts.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FOXI1 recombinant proteinDiseases associated with FOXI1 recombinant protein
 Reference Product  PubMed Publications
 SLC26A4 recombinant protein  >19 publications with FOXI1 and SLC26A4
 KCNJ10 recombinant protein  >13 publications with FOXI1 and KCNJ10
 GJB2 recombinant protein  >2 publications with FOXI1 and GJB2
 EDA recombinant protein  >1 publications with FOXI1 and EDA
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >15 publications with FOXI1 and Nervous System Diseases
 DEAFNESS, AUTOSOMAL RECESSIVE 4, WITH ENLARGED VESTIBULAR AQUEDUCT Antibodies  >10 publications with FOXI1 and DEAFNESS, AUTOSOMAL RECESSIVE 4, WITH ENLARGED VESTIBULAR AQUEDUCT
 Liver Neoplasms Antibodies  >2 publications with FOXI1 and Liver Neoplasms
 Heart Diseases Antibodies  >1 publications with FOXI1 and Heart Diseases
 Liver Neoplasms, Experimental Antibodies  >1 publications with FOXI1 and Liver Neoplasms, Experimental
 Adenocarcinoma Antibodies  >1 publications with FOXI1 and Adenocarcinoma
 Infertility, Female Antibodies  >1 publications with FOXI1 and Infertility, Female
 Fetal Death Antibodies  >1 publications with FOXI1 and Fetal Death
 Fibrosis Antibodies  >1 publications with FOXI1 and Fibrosis
 Eye Diseases Antibodies  >1 publications with FOXI1 and Eye Diseases
Organs/Tissues associated with FOXI1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >12 publications with FOXI1 and Kidney
 Lung Antibodies  >7 publications with FOXI1 and Lung
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