NP_075555.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
38,772 Da
NCBI Official Full Name
forkhead box protein L2
NCBI Official Synonym Full Names
forkhead box L2
NCBI Protein Information
forkhead box protein L2
UniProt Protein Name
Forkhead box protein L2
NCBI Summary for FOXL2
This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Expansion of a polyalanine repeat region and other mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3. [provided by RefSeq, Jul 2016]
UniProt Comments for FOXL2
Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (). Is a regulator of CYP19 expression (). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.
Research Articles on FOXL2
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Products associated with FOXL2 recombinant protein
Diseases associated with FOXL2 recombinant protein
Organs/Tissues associated with FOXL2 recombinant protein
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