NP_418092.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
NCBI Official Full Name
formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase
NCBI Protein Information
formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase
UniProt Protein Name
Formamidopyrimidine-DNA glycosylase
UniProt Synonym Protein Names
DNA-(apurinic or apyrimidinic site) lyase MutM (EC:4.2.99.18); AP lyase MutM
UniProt Synonym Gene Names
UniProt Entry Name
FPG_ECOLI
NCBI Summary for MUTM
MutM (also known as Fpg) is a DNA glycosylase that works in the base excision repair (BER) pathway to repair certain types of pre-mutagenic lesions. [More information is available at EcoCyc: EG10329].
UniProt Comments for MUTM
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG) and its derivatives such as guanidinohydantoin:C and spiroiminodihydantoin:C, however it also acts on thymine glycol:G, 5,6-dihydrouracil:G and 5-hydroxyuracil:G. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Cleaves ssDNA containing an AP site.
Research Articles on MUTM
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Products associated with MUTM recombinant protein
Pathways associated with MUTM recombinant protein
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