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FTCD recombinant protein :: Formiminotransferase Cyclodeaminase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142443 FTCD recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $3,215 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Formiminotransferase Cyclodeaminase (FTCD), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Formiminotransferase Cyclodeaminase

 Product Synonym Names    FTCD Human; Formiminotransferase Cyclodeaminase Human Recombinant; Formiminotransferase-cyclodeaminase; FTCD; LCHC1; LC-1
 Product Gene Name   

FTCD recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    229100
 3D Structure    ModBase 3D Structure for O95954
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 Host    Sf9 Insect Cells
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 Purity/Purification    Greater than 95% as determined by SDS-PAGE.
 Form/Format    FTCD is supplied in 16mM HEPES buffer pH-7.6, 240mM sodium chloride, and 20% glycerol.
 Concentration    0.35-0.7 ug/ml (depending on the type of ELISA plate and coating buffer).Suitable for biotinylation and iodination. (lot specific)
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 Immunological Functions    1. Binds IgG-type human auto-antibodies.2. Standard ELISA test (checker-board analysis of positive/negative sera panels, immuno-dot test).
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree Cfor longer periods of time. Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of FTCD recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for FTCD recombinant protein

   Description: Formiminotransferase Cyclodeaminase Human Recombinant (also called liver cytosol type 1) produced in SF9, is a glycosylated, polypeptide chain having a molecular mass of 59,749 Dalton.The FTCD is expressed with a -6xHis tag and purified by proprietary chromatographic techniques.

Introduction: Formiminotransferase cyclodeaminase is an enzyme which catalyzes the conversion of formiminoglutamateand tetrahydrofolateinto formiminotetrahydrofolateand glutamate.Formiminotransferase cyclodeaminase, a bifunctional enzyme of tetrahydrofolate synthesis, is the target antigen of anti-LC1 (liver cytosol antigen type 1) autoantibodies. Presence of LC1 autoantibodies is a marker for type 2 autoimmune hepatitis (for which anti-LKM 1/cytochrome P450 2D6 autoantibodies are a further marker).Serum LC1 autoantibody concentrations appear to fluctuate in parallel with aminotransferase levels, a particularly intriguing observation that suggests a possible role of LC1 autoreactivity in the pathogenic mechanism leading to hepatocyte injury.
 Product Categories/Family for FTCD recombinant protein    ENZYMES; Enzymes; Deaminase
NCBI/Uniprot data below describe general gene information for FTCD. It may not necessarily be applicable to this product.
 NCBI GI #    11140815
 NCBI GeneID    10841
 NCBI Accession #    NP_006648.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006657.2 [Other Products]
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 UniProt Primary Accession #    O95954 [Other Products]
 UniProt Secondary Accession #    Q86V03; Q9HCT4; Q9HCT5; Q9HCT6; Q9UHJ2; B9EGD0 [Other Products]
 UniProt Related Accession #    O95954 [Other Products]
 Molecular Weight    16,503 Da
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 NCBI Official Full Name    formimidoyltransferase-cyclodeaminase
 NCBI Official Synonym Full Names    formimidoyltransferase cyclodeaminase
 NCBI Official Symbol    FTCD [Similar Products]
 NCBI Official Synonym Symbols   
LCHC1
[Similar Products]
 NCBI Protein Information    formimidoyltransferase-cyclodeaminase; formiminotransferase cyclodeaminase; formiminotransferase-cyclodeaminase
 UniProt Protein Name    Formimidoyltransferase-cyclodeaminase
 UniProt Synonym Protein Names   
Formiminotransferase-cyclodeaminase; FTCD; LCHC1Including the following 2 domains:Glutamate formimidoyltransferase (EC:2.1.2.5)Alternative name(s):Glutamate formiminotransferase; Glutamate formyltransferase
 Protein Family    Formimidoyltransferase-cyclodeaminase
 UniProt Gene Name    FTCD [Similar Products]
 UniProt Synonym Gene Names    FTCD [Similar Products]
 UniProt Entry Name    FTCD_HUMAN
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 NCBI Summary for FTCD    The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Dec 2009]
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 UniProt Comments for FTCD    FTCD: Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool. Defects in FTCD are the cause of glutamate formiminotransferase deficiency (FIGLU-URIA); also known as formiminoglutamicaciduria (FIGLU-uria). It is an autosomal recessive disorder. Features of a severe phenotype, include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia, and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay, and no hematological abnormalities. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Methyltransferase; EC 4.3.1.4; EC 2.1.2.5; Lyase; Cofactor and Vitamin Metabolism - one carbon pool by folate; Amino Acid Metabolism - histidine

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: centriole; Golgi apparatus; cytoplasm; cytosol

Molecular Function: formimidoyltetrahydrofolate cyclodeaminase activity; glutamate formimidoyltransferase activity; folic acid binding

Biological Process: folic acid and derivative metabolic process; cytoskeleton organization and biogenesis; histidine catabolic process to glutamate and formamide; histidine catabolic process; histidine catabolic process to glutamate and formate

Disease: Formiminotransferase Deficiency
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 Research Articles on FTCD    1. FTCD is a positive regulator of the hypoxia-HIF signaling pathway and has an important role in cell proliferation, metabolism and migration in HepG2 cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FTCD recombinant proteinPathways associated with FTCD recombinant protein
 Reference Product  PubMed Publications
 GART recombinant protein  >1 publications with FTCD and GART
 MTR recombinant protein  >1 publications with FTCD and MTR
 MTHFD1L recombinant protein  >1 publications with FTCD and MTHFD1L
 MTHFD1 recombinant protein  >1 publications with FTCD and MTHFD1
 Products by Pathway  Pathway Diagram
 Histidine Catabolism Pathway antibodies  Histidine Catabolism Pathway Diagram
 Histidine Metabolism Pathway antibodies  Histidine Metabolism Pathway Diagram
 Histidine Metabolism Pathway antibodies  Histidine Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 One Carbon Metabolism Pathway antibodies  One Carbon Metabolism Pathway Diagram
 One Carbon Pool By Folate Pathway antibodies  One Carbon Pool By Folate Pathway Diagram
 One Carbon Pool By Folate Pathway antibodies  One Carbon Pool By Folate Pathway Diagram
 Histidine Degradation Pathway antibodies  Histidine Degradation Pathway Diagram
Diseases associated with FTCD recombinant proteinOrgans/Tissues associated with FTCD recombinant protein
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >13 publications with FTCD and Liver Diseases
 Brain Diseases Antibodies  >13 publications with FTCD and Brain Diseases
 Hepatitis Antibodies  >12 publications with FTCD and Hepatitis
 Disease Models, Animal Antibodies  >5 publications with FTCD and Disease Models, Animal
 Neurobehavioral Manifestations Antibodies  >5 publications with FTCD and Neurobehavioral Manifestations
 Cardiovascular Diseases Antibodies  >4 publications with FTCD and Cardiovascular Diseases
 Glutamate formiminotransferase deficiency Antibodies  >4 publications with FTCD and Glutamate formiminotransferase deficiency
 Inflammation Antibodies  >3 publications with FTCD and Inflammation
 Carcinoma, Hepatocellular Antibodies  >3 publications with FTCD and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >3 publications with FTCD and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >57 publications with FTCD and Brain
 Liver Antibodies  >19 publications with FTCD and Liver
 Kidney Antibodies  >4 publications with FTCD and Kidney
 Eye Antibodies  >3 publications with FTCD and Eye
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