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CX3CL1 recombinant protein :: Fractalkine Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS539569 CX3CL1 recombinant protein
Unit / Price
0.02 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fractalkine (CX3CL1), Recombinant Protein

 Also Known As   

Fractalkine protein

 Product Synonym Names    CX3CL1 protein; Neurotactin protein
 Product Gene Name   

CX3CL1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    Region of Fractalkin e protein correspond ing to amino acids QHHGVTKCNI TCSKMTSKIP VALLIHYQQN QASCGKRAII LETRQHRLFC ADPKEQWVKD AMQHLDRQAA ALTRNG.
 OMIM    601880
 3D Structure    ModBase 3D Structure for P78423
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 Host    Human
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 Purity/Purification    > 98% pure
 Form/Format    Supplied as a lyophilized powder.
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 Protein Type    Recombinant
 Biological Significance    Fractalkine is a CX3CL chemokine that signals through the CX3CR1 receptor. Fractalkine has been shown to chemoattract monocytes, microglia cells and NK cells. Recombinant rat Fractalkine is an 8.7 kDa protein containing 76 amino acid residues, including the four conserved cysteine residues present in CC chemokines.
 Bioactivity    Determined by its ability to chemoattract human monocytes using a concentration range of 5.0-10.0 ng/ml.
 Endotoxin Levels    Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
 Expression System    E Coli
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 Preparation and Storage    Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of CX3CL1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for CX3CL1 recombinant protein

   Purified recombinant Human Fractalkine protein
 Product Categories/Family for CX3CL1 recombinant protein    Cytokines & Growth Factors
 Applications Tested/Suitable for CX3CL1 recombinant protein   

User optimized

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NCBI/Uniprot data below describe general gene information for CX3CL1. It may not necessarily be applicable to this product.
 NCBI GI #    4506857
 NCBI GeneID    6376
 NCBI Accession #    NP_002987.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002996.3 [Other Products]
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 UniProt Primary Accession #    P78423 [Other Products]
 UniProt Secondary Accession #    O00672 [Other Products]
 UniProt Related Accession #    P78423 [Other Products]
 Molecular Weight    8.7 kDa [Similar Products]
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 NCBI Official Full Name    fractalkine isoform 1
 NCBI Official Synonym Full Names    chemokine (C-X3-C motif) ligand 1
 NCBI Official Symbol    CX3CL1 [Similar Products]
 NCBI Official Synonym Symbols   
NTN; NTT; CXC3; CXC3C; SCYD1; ABCD-3; C3Xkine; fractalkine; neurotactin
[Similar Products]
 NCBI Protein Information    fractalkine
 UniProt Protein Name    Fractalkine
 UniProt Synonym Protein Names   
C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; Neurotactin; Small-inducible cytokine D1
 Protein Family    Fractalkine
 UniProt Gene Name    CX3CL1 [Similar Products]
 UniProt Synonym Gene Names    FKN; NTT; SCYD1 [Similar Products]
 UniProt Entry Name    X3CL1_HUMAN
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 UniProt Comments for CX3CL1    CX3CL1: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1. Belongs to the intercrine delta family.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16q13

Cellular Component: extracellular space; cell surface; extracellular region; plasma membrane; integral to membrane

Molecular Function: protein binding; chemokine activity; receptor binding

Biological Process: neutrophil chemotaxis; positive regulation of transforming growth factor-beta1 production; cytokine and chemokine mediated signaling pathway; leukocyte chemotaxis; defense response; chemotaxis; angiogenesis involved in wound healing; macrophage chemotaxis; leukocyte adhesive activation; positive regulation of angiogenesis; positive regulation of calcium-independent cell-cell adhesion; immune response; cell adhesion; lymphocyte chemotaxis; positive regulation of inflammatory response
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 Research Articles on CX3CL1    1. CX3CL1 induces recruitment of CX3CR1(+)ICAM-1(+)CD4(+) T-cells into the central nervous system (CNS) during the early inflammatory response in multiple sclerosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CX3CL1 recombinant proteinPathways associated with CX3CL1 recombinant protein
 Reference Product  PubMed Publications
 CX3CR1 recombinant protein  >499 publications with CX3CL1 and CX3CR1
 CCR2 recombinant protein  >61 publications with CX3CL1 and CCR2
 CCR5 recombinant protein  >37 publications with CX3CL1 and CCR5
 CXCR3 recombinant protein  >30 publications with CX3CL1 and CXCR3
 CCR1 recombinant protein  >19 publications with CX3CL1 and CCR1
 CCR7 recombinant protein  >13 publications with CX3CL1 and CCR7
 CXCR2 recombinant protein  >13 publications with CX3CL1 and CXCR2
 CCR3 recombinant protein  >13 publications with CX3CL1 and CCR3
 CXCR1 recombinant protein  >8 publications with CX3CL1 and CXCR1
 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
Diseases associated with CX3CL1 recombinant proteinOrgans/Tissues associated with CX3CL1 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >346 publications with CX3CL1 and Inflammation
 Necrosis Antibodies  >181 publications with CX3CL1 and Necrosis
 Cardiovascular Diseases Antibodies  >153 publications with CX3CL1 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >94 publications with CX3CL1 and Atherosclerosis
 Lung Diseases Antibodies  >67 publications with CX3CL1 and Lung Diseases
 Pain Antibodies  >61 publications with CX3CL1 and Pain
 Kidney Diseases Antibodies  >57 publications with CX3CL1 and Kidney Diseases
 Heart Diseases Antibodies  >49 publications with CX3CL1 and Heart Diseases
 Liver Diseases Antibodies  >49 publications with CX3CL1 and Liver Diseases
 Myocardial Ischemia Antibodies  >40 publications with CX3CL1 and Myocardial Ischemia
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >191 publications with CX3CL1 and Brain
 Muscle Antibodies  >94 publications with CX3CL1 and Muscle
 Kidney Antibodies  >86 publications with CX3CL1 and Kidney
 Lung Antibodies  >84 publications with CX3CL1 and Lung
 Heart Antibodies  >67 publications with CX3CL1 and Heart
 Liver Antibodies  >63 publications with CX3CL1 and Liver
 Nerve Antibodies  >53 publications with CX3CL1 and Nerve
 Skin Antibodies  >42 publications with CX3CL1 and Skin
 Intestine Antibodies  >33 publications with CX3CL1 and Intestine
 Eye Antibodies  >27 publications with CX3CL1 and Eye
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