NP_072145.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
60,355 Da
NCBI Official Full Name
frizzled-4
NCBI Official Synonym Full Names
frizzled class receptor 4
NCBI Protein Information
frizzled-4
UniProt Protein Name
Frizzled-4
UniProt Synonym Protein Names
CD_antigen: CD344
UniProt Synonym Gene Names
NCBI Summary for Fzd4
putative Wnt receptor; may play a role in the Wnt signaling pathway [RGD, Feb 2006]
UniProt Comments for Fzd4
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues ().
Research Articles on Fzd4
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Pathways associated with Fzd4 recombinant protein
Diseases associated with Fzd4 recombinant protein
Organs/Tissues associated with Fzd4 recombinant protein
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