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FBP1 recombinant protein :: Fructose-1,6-Bisphosphatase 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143831 FBP1 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,235 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fructose-1,6-Bisphosphatase 1 (FBP1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Fructose-1,6-Bisphosphatase 1

 Product Synonym Names    FBP1 Human; Fructose-1,6-Bisphosphatase 1 Human Recombinant; FBP1; FBP; D-fructose-1; 6-bisphosphate 1-phosphohydrolase 1; FBPase 1; Fructose-1; 6-bisphosphatase 1
 Product Gene Name   

FBP1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MADQAPFDTD VNTLTRFVME EGRKARGTGE LTQLLNSLCT AVKAISSAVR KAGIAHLYGI AGSTNVTGDQ VKKLDVLSND LVMNMLKSSF ATCVLVSEED KHAIIVEPEK RGKYVVCFDP LDGSSNIDCL VSVGTIFGIY RKKSTDEPSE KDALQPGRNL VAAGYALYGS ATMLVLAMDC GVNCFMLDPA IGEFILVDKD VKIKKKGKIY SLNEGYARDF DPAVTEYIQR KKFPPDNSAP YGARYVGSMV ADVHRTLVYG GIFLYPANKK SPNGKLRLLY ECNPMAYVME KAGGMATTGK EAVLDVIPTD IHQRAPVILG SPDDVLEFLK VYEKHSAQ
 OMIM    229700
 3D Structure    ModBase 3D Structure for P09467
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE.
 Form/Format    The FBP1 protein solution is formulated in 20mM Tris-HCl pH-8, 1mM DTT and 10% glycerol.
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 Source    Escherichia Coli.
 Physical Appearance    Sterile Filtered clear solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of FBP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for FBP1 recombinant protein

   Description: The FBP1 Human recombinant protein is a single, non-glycosilated polypeptide chain produced in E Coli, having a molecular weight of 39kDa and containing 358 amino acids (1-338 a.a.). The FBP1 enzyme is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatography techniques.

Introduction: FBP1 is a gluconeogenesis regulatory protein which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. FBP1 deficiency is associated with hypoglycemia and metabolic acidosis. FBP1 regulates mouse endogenous glucose production. FBP1 coupled with phosphofructokinase (PFK) takes part in the metabolism of pancreatic islet cells.
 Product Categories/Family for FBP1 recombinant protein    ENZYMES; Enzymes; Phosphatase
NCBI/Uniprot data below describe general gene information for FBP1. It may not necessarily be applicable to this product.
 NCBI GI #    16579888
 NCBI GeneID    2203
 NCBI Accession #    NP_000498.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000507.3 [Other Products]
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 UniProt Primary Accession #    P09467 [Other Products]
 UniProt Secondary Accession #    O75571; Q53F94; Q96E46 [Other Products]
 UniProt Related Accession #    P09467 [Other Products]
 Molecular Weight    36,842 Da
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 NCBI Official Full Name    fructose-1,6-bisphosphatase 1
 NCBI Official Synonym Full Names    fructose-1,6-bisphosphatase 1
 NCBI Official Symbol    FBP1 [Similar Products]
 NCBI Official Synonym Symbols   
FBP
[Similar Products]
 NCBI Protein Information    fructose-1,6-bisphosphatase 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; FBPase 1; fructose-bisphosphatase 1; growth-inhibiting protein 17; liver FBPase
 UniProt Protein Name    Fructose-1,6-bisphosphatase 1
 UniProt Synonym Protein Names   
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; Liver FBPase
 Protein Family    Fat-body protein
 UniProt Gene Name    FBP1 [Similar Products]
 UniProt Synonym Gene Names    FBP; FBPase 1 [Similar Products]
 UniProt Entry Name    F16P1_HUMAN
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 NCBI Summary for FBP1    Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FBP1    FBPase: a key enzyme of gluconeogenesis that catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate, a precursor to glucose 6-phosphate. A regulator of glucose synthesis from non-carbohydrates. Two paralogs of this enzyme exists in humans, FBP1 in the liver and FBP2 in muscle. While both forms are inhibited allosterically by AMP, NAD and Ca2+, the muscle form is about 100-fold more sensitive to AMP and NAD, and about 1000-fold more sensitive to inhibition by Ca2+. Forms homotetramers that are stabilized in the active state by divalent cations (Mg2+, Mn2+ , Co+2, or Zn2+). Deficiency of FBP1 leads to a disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.

Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Phosphatase (non-protein); EC 3.1.3.11; Mitochondrial; Carbohydrate Metabolism - pentose phosphate pathway; Carbohydrate Metabolism - fructose and mannose

Chromosomal Location of Human Ortholog: 9q22.3

Cellular Component: cytoplasm; cytosol

Molecular Function: monosaccharide binding; identical protein binding; protein binding; metal ion binding; fructose-bisphosphatase activity; AMP binding

Biological Process: dephosphorylation; carbohydrate metabolic process; glucose metabolic process; negative regulation of Ras protein signal transduction; regulation of gluconeogenesis; pathogenesis; negative regulation of cell growth; fructose 6-phosphate metabolic process; negative regulation of glycolysis; fructose metabolic process; protein homotetramerization; gluconeogenesis

Disease: Fructose-1,6-bisphosphatase Deficiency
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 Research Articles on FBP1    1. the gluconeogenic enzyme fructose-1,6-bisphosphatase 1 (FBP1) is uniformly depleted in over six hundred clear cell renal cell carcinoma tumours examined.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FBP1 recombinant proteinPathways associated with FBP1 recombinant protein
 Reference Product  PubMed Publications
 GPI recombinant protein  >7 publications with FBP1 and GPI
 MDH2 recombinant protein  >3 publications with FBP1 and MDH2
 PFKL recombinant protein  >1 publications with FBP1 and PFKL
 TALDO1 recombinant protein  >1 publications with FBP1 and TALDO1
 TKT recombinant protein  >1 publications with FBP1 and TKT
 ALDOB recombinant protein  >1 publications with FBP1 and ALDOB
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Gluconeogenesis Pathway antibodies  Gluconeogenesis Pathway Diagram
 Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway antibodies  Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway Diagram
 Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway antibodies  Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway Diagram
Diseases associated with FBP1 recombinant proteinOrgans/Tissues associated with FBP1 recombinant protein
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >9 publications with FBP1 and Liver Diseases
 Fructose-1,6-Diphosphatase Deficiency Antibodies  >7 publications with FBP1 and Fructose-1,6-Diphosphatase Deficiency
 Kidney Diseases Antibodies  >5 publications with FBP1 and Kidney Diseases
 Liver Neoplasms Antibodies  >4 publications with FBP1 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >4 publications with FBP1 and Carcinoma, Hepatocellular
 Hepatomegaly Antibodies  >3 publications with FBP1 and Hepatomegaly
 Inflammation Antibodies  >3 publications with FBP1 and Inflammation
 Necrosis Antibodies  >3 publications with FBP1 and Necrosis
 Neoplasms, Experimental Antibodies  >3 publications with FBP1 and Neoplasms, Experimental
 Hyperglycemia Antibodies  >3 publications with FBP1 and Hyperglycemia
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >22 publications with FBP1 and Liver
 Blood Antibodies  >18 publications with FBP1 and Blood
 Kidney Antibodies  >8 publications with FBP1 and Kidney
 Lung Antibodies  >3 publications with FBP1 and Lung
 Prostate Antibodies  >2 publications with FBP1 and Prostate
 Pancreas Antibodies  >2 publications with FBP1 and Pancreas
 Intestine Antibodies  >2 publications with FBP1 and Intestine
 Connective Tissue Antibodies  >1 publications with FBP1 and Connective Tissue
 Bladder Antibodies  >1 publications with FBP1 and Bladder
 Stomach Antibodies  >1 publications with FBP1 and Stomach
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