NP_062268.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,912 Da
NCBI Official Full Name
fructose-1,6-bisphosphatase 1
NCBI Official Synonym Full Names
fructose bisphosphatase 1
NCBI Protein Information
fructose-1,6-bisphosphatase 1
UniProt Protein Name
Fructose-1,6-bisphosphatase 1
UniProt Synonym Protein Names
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; Fructose-1,6-bisphosphatase isozyme 3; FBPase 3; Liver FBPase
UniProt Synonym Gene Names
UniProt Comments for Fbp1
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
Research Articles on Fbp1
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Pathways associated with Fbp1 recombinant protein
Diseases associated with Fbp1 recombinant protein
Organs/Tissues associated with Fbp1 recombinant protein
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