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GADD45B recombinant protein

Scan QR to view Datasheet Catalog #    MBS203204
SDS-Page
Unit / Price
0.1 mg  /  $255 +1 FREE 8GB USB
0.5 mg  /  $535 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GADD45B, Recombinant Protein

 Also Known As   

GADD45B, 1-160aa, Human, E Coli

 Product Synonym Names    Growth arrest and DNA-damage-inducible beta; MYD118; Growth arrest and DNA-damage-inducible beta; GADD45B; Growth arrest and DNA-damage-inducible; beta GADD45 Beta; GADD45BETA; ADD45 beta; growth arrest and DNA-damage-inducible 45 beta; Growth arrest and DNA-damage-inducible protein; myeloid differentiation primary response gene; Myeloid differentiation primary response protein MyD118; Negative growth-regulatory protein MyD118.
 Product Gene Name   

GADD45B recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MTLEELVACD NAAQKMQTVT AAVEELLVAA QRQDRLTVGV YESAKLMNVD PDSVVLCLLA IDEEEEDDIA LQIHFTLIQS FCCDNDINIV RVSGMQRLAQ LLGEPAETQG TTEARDLHCL LVTNPHTDAW KSHGLVEVAS YCEESRGNNQ WVPYISLQER
 OMIM    AF090950 mRNA
 3D Structure    ModBase 3D Structure for O75293
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl Buffer (pH 7.5)
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of GADD45B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for GADD45B recombinant protein

   GADD45B is a member of GADD45 family (GADD45alpha, beta, and gamma) that are nuclear proteins to interact with various proteins implicated in stress responses and cell-cycle-related proteins. The function of GADD45 proteins is involved in growth-regulatory mechanisms and apoptosis. GADD45B is necessary for adult neurogenesis, including brain-derived neurotrophic factor and fibroblast growth factor. And therefore, this protein is implicated in affecting synaptic plasticity. Recombinant GADD45B protein was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for GADD45B recombinant protein    Cell Cycle
 Applications Tested/Suitable for GADD45B recombinant protein   

SDS-PAGE

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 SDS-Page of GADD45B recombinant protein    GADD45B recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for GADD45B. It may not necessarily be applicable to this product.
 NCBI GI #    86991436
 NCBI GeneID    4616
 NCBI Accession #    NP_056490 [Other Products]
 NCBI GenBank Nucleotide #    NM_015675.3 [Other Products]
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 UniProt Primary Accession #    O75293 [Other Products]
 UniProt Secondary Accession #    O75960; Q17R46; A8KAM2 [Other Products]
 UniProt Related Accession #    O75293 [Other Products]
 Molecular Weight    17.8 kDa (160 aa), confirmed by MALDI-TOF.
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 NCBI Official Full Name    growth arrest and DNA damage-inducible protein GADD45 beta
 NCBI Official Synonym Full Names    growth arrest and DNA damage inducible beta
 NCBI Official Symbol    GADD45B [Similar Products]
 NCBI Official Synonym Symbols   
MYD118; GADD45BETA
[Similar Products]
 NCBI Protein Information    growth arrest and DNA damage-inducible protein GADD45 beta
 UniProt Protein Name    Growth arrest and DNA damage-inducible protein GADD45 beta
 UniProt Synonym Protein Names   
Myeloid differentiation primary response protein MyD118; Negative growth regulatory protein MyD118
 Protein Family    Growth arrest and DNA damage-inducible protein
 UniProt Gene Name    GADD45B [Similar Products]
 UniProt Synonym Gene Names    MYD118 [Similar Products]
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 NCBI Summary for GADD45B    This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GADD45B    Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.
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Product References and Citations for GADD45B recombinant protein

   Takekawa M., et al. (1998) Cell 95 (4), 521-30; Zerbini LF., et al. (2004) PNAS 101 (37), 13618-23;
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 Research Articles on GADD45B    1. present study provides evidence that variations in GADD45B rs2024144T, MAPK14 rs3804451A and GADD45A rs581000C may predict platinum-based chemotherapy toxicity outcomes in patients with advanced non-small cell lung cancer
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GADD45B recombinant proteinPathways associated with GADD45B recombinant protein
 Reference Product  PubMed Publications
 GADD45A recombinant protein  >67 publications with GADD45B and GADD45A
 GADD45G recombinant protein  >38 publications with GADD45B and GADD45G
 PCNA recombinant protein  >15 publications with GADD45B and PCNA
 MAP2K3 recombinant protein  >3 publications with GADD45B and MAP2K3
 JAK2 recombinant protein  >2 publications with GADD45B and JAK2
 IL18 recombinant protein  >2 publications with GADD45B and IL18
 MAP3K4 recombinant protein  >2 publications with GADD45B and MAP3K4
 MAP2K6 recombinant protein  >1 publications with GADD45B and MAP2K6
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 DNA Damage Response Pathway antibodies  DNA Damage Response Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
 IL12-mediated Signaling Events Pathway antibodies  IL12-mediated Signaling Events Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
Diseases associated with GADD45B recombinant proteinOrgans/Tissues associated with GADD45B recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >30 publications with GADD45B and Necrosis
 Inflammation Antibodies  >27 publications with GADD45B and Inflammation
 Nervous System Diseases Antibodies  >26 publications with GADD45B and Nervous System Diseases
 Liver Diseases Antibodies  >26 publications with GADD45B and Liver Diseases
 Disease Models, Animal Antibodies  >25 publications with GADD45B and Disease Models, Animal
 Brain Diseases Antibodies  >19 publications with GADD45B and Brain Diseases
 Liver Neoplasms Antibodies  >19 publications with GADD45B and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >18 publications with GADD45B and Carcinoma, Hepatocellular
 Cardiovascular Diseases Antibodies  >16 publications with GADD45B and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >14 publications with GADD45B and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >51 publications with GADD45B and Blood
 Brain Antibodies  >50 publications with GADD45B and Brain
 Liver Antibodies  >49 publications with GADD45B and Liver
 Lung Antibodies  >23 publications with GADD45B and Lung
 Bone Antibodies  >19 publications with GADD45B and Bone
 Muscle Antibodies  >14 publications with GADD45B and Muscle
 Bone Marrow Antibodies  >13 publications with GADD45B and Bone Marrow
 Nerve Antibodies  >13 publications with GADD45B and Nerve
 Heart Antibodies  >13 publications with GADD45B and Heart
 Prostate Antibodies  >10 publications with GADD45B and Prostate
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