NP_066564
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
51.1kDa (447a), confirmed by MALDI-TOF
NCBI Official Full Name
histone acetyltransferase KAT2A
NCBI Official Synonym Full Names
lysine acetyltransferase 2A
NCBI Protein Information
histone acetyltransferase KAT2A
UniProt Protein Name
Histone acetyltransferase KAT2A
UniProt Synonym Protein Names
General control of amino acid synthesis protein 5-like 2; Histone acetyltransferase GCN5; HsGCN5; Lysine acetyltransferase 2A; STAF97
UniProt Synonym Gene Names
NCBI Summary for GCN5L2
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]
UniProt Comments for GCN5L2
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Also acetylates non-histone proteins, such as CEBPB (PubMed:17301242). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.
Product References and Citations for GCN5L2 recombinant protein
Guelman S., et al. (2009) Mol. Cell. Biol. 29:1176-1188; Col E., et al. (2001) J. Biol. Chem. 276:28179-28184
Research Articles on GCN5L2
Precautions
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Products associated with GCN5L2 recombinant protein
Pathways associated with GCN5L2 recombinant protein
Diseases associated with GCN5L2 recombinant protein
Organs/Tissues associated with GCN5L2 recombinant protein
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