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GDF-5 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203335
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GDF-5, Recombinant Protein

 Also Known As   

GDF-5, 382-501aa, Human, His tag, E Coli

 Product Synonym Names    Growth differentiation factor 5; Growth differentiation factor 5; BMP14; CDMP1; LAP4; OS5; SYNS2; Growth differentiation factor 5 Cartilage derived morphogenetic protein 1
 Product Gene Name   

GDF-5 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MAPLATRQGK RPSKNLKARC SRKALHVNFK DMGWDDWIIA PLEYEAFHCE GLCEFPLRSH LEPTNHAVIQ TLMNSMDPES TPPTCCVPTR LSPISILFID SANNVVYKQY EDMVVESCGC R
 OMIM    X80915 Genomic DNA
 3D Structure    ModBase 3D Structure for P43026
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. In 10 mM Sodium citrate pH 3.5, 10% glycerol
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
 Endotoxin Level    < 1.0 EU per 1 microgram of protein (determined by LAL method)
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of GDF-5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for GDF-5 recombinant protein

   Growth differentiation factor 5 (GDF-5) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This protein plays a role in chondrogenesis and chondrocyte metabolism, tendon and ligament tissue formation, and bone repair. It also increases the survival of neurones that respond to a neurotransmitter called dopamine, and is a potential therapeutic molecule associated with Parkinson's disease. GDF-5, fused to His-tag at N-terminus, was expressed as insoluble protein aggregate in E Coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
 Product Categories/Family for GDF-5 recombinant protein    Hormones & Cytokines
 Applications Tested/Suitable for GDF-5 recombinant protein   

SDS-PAGE

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 SDS-Page of GDF-5 recombinant protein    GDF-5 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for GDF-5. It may not necessarily be applicable to this product.
 NCBI GI #    611435007
 NCBI GeneID    8200
 NCBI Accession #    NP_000548 [Other Products]
 NCBI GenBank Nucleotide #    NM_000557.4 [Other Products]
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 UniProt Primary Accession #    P43026 [Other Products]
 UniProt Secondary Accession #    Q96SB1; E1P5Q2 [Other Products]
 UniProt Related Accession #    P43026 [Other Products]
 Molecular Weight    15.8 kDa (141aa), confirmed by MALDI-TOF.
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 NCBI Official Full Name    growth/differentiation factor 5 preproprotein
 NCBI Official Synonym Full Names    growth differentiation factor 5
 NCBI Official Symbol    GDF5 [Similar Products]
 NCBI Official Synonym Symbols   
OS5; LAP4; BDA1C; BMP14; CDMP1; LAP-4; SYM1B; SYNS2; BMP-14
[Similar Products]
 NCBI Protein Information    growth/differentiation factor 5
 UniProt Protein Name    Growth/differentiation factor 5
 UniProt Synonym Protein Names   
Bone morphogenetic protein 14; BMP-14; Cartilage-derived morphogenetic protein 1; CDMP-1; Lipopolysaccharide-associated protein 4; LAP-4; LPS-associated protein 4; Radotermin
 UniProt Gene Name    GDF5 [Similar Products]
 UniProt Synonym Gene Names    BMP14; CDMP1; GDF-5; BMP-14; CDMP-1; LAP-4; LPS-associated protein 4 [Similar Products]
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 NCBI Summary for GDF-5    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates the development of numerous tissue and cell types, including cartilage, joints, brown fat, teeth, and the growth of neuronal axons and dendrites. Mutations in this gene are associated with acromesomelic dysplasia, brachydactyly, chondrodysplasia, multiple synostoses syndrome, proximal symphalangism, and susceptibility to osteoarthritis. [provided by RefSeq, Aug 2016]
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 UniProt Comments for GDF-5    Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (PubMed:24098149, PubMed:21976273, PubMed:15530414, PubMed:25092592). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (PubMed:21976273). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205).
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Product References and Citations for GDF-5 recombinant protein

   Feng G., et al. (2008). Growth Factor. 26 (3):132-42; Sullivan AM., et al. (2005). J Anat. 207 (3):219-26.;
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 Research Articles on GDF-5    1. BMP-14 rs143383 polymorphism reduced the susceptibility to knee osteoarthritis (OA) and hand OA not only in total analysis but also in subgroup analysis; BMP-14 rs143383 polymorphism may be a protective factor against OA occurrence
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GDF-5 recombinant proteinPathways associated with GDF-5 recombinant protein
 Reference Product  PubMed Publications
 BMPR1B recombinant protein  >27 publications with GDF-5 and BMPR1B
 BMPR2 recombinant protein  >23 publications with GDF-5 and BMPR2
 NOG recombinant protein  >18 publications with GDF-5 and NOG
 BMPR1A recombinant protein  >13 publications with GDF-5 and BMPR1A
 Products by Pathway  Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Differentiation Pathway antibodies  Differentiation Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Molecules Associated With Elastic Fibres Pathway antibodies  Molecules Associated With Elastic Fibres Pathway Diagram
Diseases associated with GDF-5 recombinant proteinOrgans/Tissues associated with GDF-5 recombinant protein
 Disease Name  Pubmed Publications
 Osteoarthritis Antibodies  >95 publications with GDF-5 and Osteoarthritis
 Disease Models, Animal Antibodies  >30 publications with GDF-5 and Disease Models, Animal
 Brachydactyly type C Antibodies  >14 publications with GDF-5 and Brachydactyly type C
 Inflammation Antibodies  >14 publications with GDF-5 and Inflammation
 Brachydactyly type A2 Antibodies  >10 publications with GDF-5 and Brachydactyly type A2
 ACROMESOMELIC DYSPLASIA, HUNTER-THOMPSON TYPE Antibodies  >7 publications with GDF-5 and ACROMESOMELIC DYSPLASIA, HUNTER-THOMPSON TYPE
 Fibrosis Antibodies  >6 publications with GDF-5 and Fibrosis
 Necrosis Antibodies  >6 publications with GDF-5 and Necrosis
 Arthritis, Rheumatoid Antibodies  >6 publications with GDF-5 and Arthritis, Rheumatoid
 Chondrodysplasia, Grebe type Antibodies  >4 publications with GDF-5 and Chondrodysplasia, Grebe type
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >334 publications with GDF-5 and Bone
 Connective Tissue Antibodies  >98 publications with GDF-5 and Connective Tissue
 Embryonic Tissue Antibodies  >47 publications with GDF-5 and Embryonic Tissue
 Brain Antibodies  >22 publications with GDF-5 and Brain
 Skin Antibodies  >14 publications with GDF-5 and Skin
 Eye Antibodies  >10 publications with GDF-5 and Eye
 Heart Antibodies  >8 publications with GDF-5 and Heart
 Lung Antibodies  >5 publications with GDF-5 and Lung
 Prostate Antibodies  >4 publications with GDF-5 and Prostate
 Uterus Antibodies  >4 publications with GDF-5 and Uterus
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