NP_005802
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14.8kDa (132aa)
NCBI Official Full Name
growth/differentiation factor 11 preproprotein
NCBI Official Synonym Full Names
growth differentiation factor 11
NCBI Protein Information
growth/differentiation factor 11
UniProt Protein Name
Growth/differentiation factor 11
UniProt Synonym Protein Names
Bone morphogenetic protein 11
UniProt Synonym Gene Names
NCBI Summary for GDF11
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging. [provided by RefSeq, Aug 2016]
UniProt Comments for GDF11
Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. May play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern (). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:28257634).
Research Articles on GDF11
Precautions
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Products associated with GDF11 recombinant protein
Diseases associated with GDF11 recombinant protein
Organs/Tissues associated with GDF11 recombinant protein
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