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GDF11 recombinant protein

Scan QR to view Datasheet Catalog #    MBS538017 GDF11 recombinant protein
Unit / Price
0.02 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GDF11, Recombinant Protein

 Also Known As   

GDF11 protein

 Product Synonym Names    BMP-11 protein; GDF 11 protein; GDF-11 protein; GDF-11; Growth/Differentiation Factor-11 protein; GDF11; GDF 11
 Product Gene Name   

GDF11 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    Region of GDF11 protein correspond ing to amino acids NLGLDCDEHS SESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGQCEYM FMQKYPHTHL VQQANPRGSA GPCCTPTKMS PINMLYFNDK QQIIYGKIPG MVVDRCGCS.
 OMIM    603936
 3D Structure    ModBase 3D Structure for O95390
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 Host    Human
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 Purity/Purification    > 98% by SDS-PAGE analysis and HPLC
 Form/Format    Sterile Filtered through a 0.2 micron filter. Lyophilized with no additives. Centrifuge vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0mg/ml. Keep pH below 5.0. Do not vortex.
 Concentration    20 ug per vial: lyophilized (lot specific)
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 Protein Type    Recombinant
 Biological Significance    GDF-11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF-11 has been shown to suppress neurogenesis through a myostatin-like pathway, which involves arrest of progenitor cell-cycle in the G1 phase. Similarities between myostatin and GDF-11, which are 90% identical in their amino acid sequence, suggests that the regulatory mechanisms responsible for maintaining proper tissue size during neural and muscular development might be the same.
 Bioactivity    The ED50 was determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The expected ED50 for this effect is 0.08-0.10 ug/ml.
 Biohazard    Use normal laboratory precautions and techniques when handling this reagent.
 Endotoxin Levels    Endotoxin level is less than 0.1 ng/ug
 Source    E Coli
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 Preparation and Storage    Ships ambient or refrigerated. Upon receipt store at -20 degree C. After reconstituted, the undiluted solution is stable at 4 degree C for up to 1 week. For extended storage, dilute further in a buffer containing a carrier protein and store in working aliquots at -20 degree C to -80 degree C. Avoid repeat freeze-thaw cycles.
 Other Notes    Small volumes of GDF11 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for GDF11 recombinant protein

   Purified recombinant Human GDF11 protein
 Product Categories/Family for GDF11 recombinant protein    Cytokines & Growth Factors
 Applications Tested/Suitable for GDF11 recombinant protein   

User optimized

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NCBI/Uniprot data below describe general gene information for GDF11. It may not necessarily be applicable to this product.
 NCBI GI #    5031613
 NCBI GeneID    10220
 NCBI Accession #    NP_005802.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005811.3 [Other Products]
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 UniProt Primary Accession #    O95390 [Other Products]
 UniProt Secondary Accession #    Q9UID1; Q9UID2 [Other Products]
 UniProt Related Accession #    O95390 [Other Products]
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 NCBI Official Full Name    growth/differentiation factor 11
 NCBI Official Synonym Full Names    growth differentiation factor 11
 NCBI Official Symbol    GDF11 [Similar Products]
 NCBI Official Synonym Symbols   
BMP11; BMP-11
[Similar Products]
 NCBI Protein Information    growth/differentiation factor 11
 UniProt Protein Name    Growth/differentiation factor 11
 UniProt Synonym Protein Names   
Bone morphogenetic protein 11; BMP-11
 UniProt Gene Name    GDF11 [Similar Products]
 UniProt Synonym Gene Names    BMP11; GDF-11; BMP-11 [Similar Products]
 UniProt Entry Name    GDF11_HUMAN
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 NCBI Summary for GDF11    The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GDF11    GDF11: Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q13.2

Cellular Component: extracellular space

Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: nervous system development; cell maturation; palate development; regulation of apoptosis; negative regulation of cell proliferation; negative regulation of cell differentiation; camera-type eye morphogenesis; spinal cord anterior/posterior patterning; ureteric bud development; regulation of MAPKKK cascade; pancreas development; mesoderm development; metanephros development; skeletal development; cell development; growth
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 Research Articles on GDF11    1. Suggest GDF11 functions as encephalic regionalizing factor in neural differentiated mouse embryonic stem cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to GDF11 protein
 Catalog #  Product Name  Catalog #  Product Name
 MBS2502734  Human GDF11 (Growth Differentiation Factor 11) ELISA Kit  MBS2000806  Growth Differentiation Factor 11 (GDF11) CLIA Kit
 MBS2000637  Growth Differentiation Factor 11 (GDF11) CLIA Kit  MBS2014017  Biotin-Linked Antibody to Growth Differentiation Factor 11 (GDF11)
 MBS2532495  Mouse GDF11 (Growth Differentiation Factor 11) CLIA Kit  MBS205864  GDF11, 299-407aa, Human, His tag, E Coli
 MBS2532641  Human GDF11 (Growth Differentiation Factor 11) CLIA Kit  MBS9213164  GDF11 Antibody (N-term)
 MBS2022680  Growth Differentiation Factor 11 (GDF11) ELISA Kit  MBS2501347  Rabbit GDF11 (Growth Differentiation Factor 11) ELISA Kit
Products associated with GDF11 recombinant proteinDiseases associated with GDF11 recombinant protein
 Reference Product  PubMed Publications
 WFIKKN2 recombinant protein  >4 publications with GDF11 and WFIKKN2
 ACVR2B recombinant protein  >3 publications with GDF11 and ACVR2B
 ACVR1C recombinant protein  >2 publications with GDF11 and ACVR1C
 ACVR1B recombinant protein  >2 publications with GDF11 and ACVR1B
 MAFA recombinant protein  >1 publications with GDF11 and MAFA
 FOXG1 recombinant protein  >1 publications with GDF11 and FOXG1
 PAX6 recombinant protein  >1 publications with GDF11 and PAX6
 ATOH7 recombinant protein  >1 publications with GDF11 and ATOH7
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >5 publications with GDF11 and Disease Models, Animal
 Atrophy Antibodies  >3 publications with GDF11 and Atrophy
 Kidney Diseases Antibodies  >3 publications with GDF11 and Kidney Diseases
 Brain Diseases Antibodies  >2 publications with GDF11 and Brain Diseases
 Anemia, Hemolytic Antibodies  >2 publications with GDF11 and Anemia, Hemolytic
 Urogenital Abnormalities Antibodies  >1 publications with GDF11 and Urogenital Abnormalities
 Hyperplasia Antibodies  >1 publications with GDF11 and Hyperplasia
 Fatty Liver Antibodies  >1 publications with GDF11 and Fatty Liver
 Pain Antibodies  >1 publications with GDF11 and Pain
 Inflammation Antibodies  >1 publications with GDF11 and Inflammation
Organs/Tissues associated with GDF11 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >81 publications with GDF11 and Bone
 Muscle Antibodies  >35 publications with GDF11 and Muscle
 Blood Antibodies  >20 publications with GDF11 and Blood
 Embryonic Tissue Antibodies  >16 publications with GDF11 and Embryonic Tissue
 Heart Antibodies  >11 publications with GDF11 and Heart
 Nerve Antibodies  >11 publications with GDF11 and Nerve
 Kidney Antibodies  >9 publications with GDF11 and Kidney
 Brain Antibodies  >9 publications with GDF11 and Brain
 Eye Antibodies  >6 publications with GDF11 and Eye
 Liver Antibodies  >5 publications with GDF11 and Liver
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