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GDF15 recombinant protein

Scan QR to view Datasheet Catalog #    MBS205834
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GDF15, Recombinant Protein

★Popular Item★
 Also Known As   

GDF15, 189-303aa, Mouse, His tag, E Coli (Denatured)

 Product Synonym Names    Growth/differentiation factor 15 precursor; Growth/differentiation factor 15 precursor; MIC-1; NAG-1; SBF
 Product Gene Name   

GDF15 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MGSSAHAHPR DSCPLGPGRC CHLETVQATL EDLGWSDWVL SPRQLQLSMC VGECPHLYRS ANTHAQIKAR LHGLQPDKVP APCCVPSSYT PVVLMHRTDS GVSLQTYDDL VARGCHCA
 3D Structure    ModBase 3D Structure for Q9Z0J7
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 Host    E Coli
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 Purity/Purification    > 90% by SDS-PAGE
 Form/Format    Liquid. In 20mM Phosphate buffer (pH 8.0) containing 10% glycerol.
 Concentration    1.0 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Mouse
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of GDF15 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for GDF15 recombinant protein

   Growth/differentiation factor 15, also known as GDF15, is a member of the TGF superfamily. It has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein. Recombinant mouse GDF15 fused to His-tag at N-terminus, was expressed in E Coli.
 Product Categories/Family for GDF15 recombinant protein    Hormones & Cytokines
 Applications Tested/Suitable for GDF15 recombinant protein   

SDS-PAGE

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 SDS-Page of GDF15 recombinant protein    GDF15 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for GDF15. It may not necessarily be applicable to this product.
 NCBI GI #    170784848
 NCBI GeneID    23886
 NCBI Accession #    NP_035949 [Other Products]
 NCBI GenBank Nucleotide #    NM_011819.3 [Other Products]
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 UniProt Primary Accession #    Q9Z0J7 [Other Products]
 UniProt Secondary Accession #    Q6NX63 [Other Products]
 UniProt Related Accession #    Q9Z0J7 [Other Products]
 Molecular Weight    14.9 kDa (138aa)
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 NCBI Official Full Name    growth/differentiation factor 15 preproprotein
 NCBI Official Synonym Full Names    growth differentiation factor 15
 NCBI Official Symbol    Gdf15 [Similar Products]
 NCBI Official Synonym Symbols   
SBF; MIC-1; NAG-1
[Similar Products]
 NCBI Protein Information    growth/differentiation factor 15
 UniProt Protein Name    Growth/differentiation factor 15
 Protein Family    Growth/differentiation factor
 UniProt Gene Name    Gdf15 [Similar Products]
 UniProt Synonym Gene Names    Sbf; GDF-15 [Similar Products]
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 NCBI Summary for GDF15    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. Mice lacking a functional copy of this gene exhibit progressive loss of motor neurons, and more rapid blood clot formation. [provided by RefSeq, Aug 2016]
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Product References and Citations for GDF15 recombinant protein

   Zimmers TA, Jin X, et al. (2005). Shock. 23 (6):543-8.; Hsiao EC, Koniaris LG, et al. (2000). Mol Cell Biol. 20 (10):3742-51.;
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 Research Articles on GDF15    1. These data suggest that GDF15 is required for IL-13-induced improvement of glucose intolerance in mice fed an HFD.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GDF15 recombinant proteinDiseases associated with GDF15 recombinant protein
 Reference Product  PubMed Publications
 Hamp recombinant protein  >42 publications with GDF15 and Hamp
 Trp53 recombinant protein  >39 publications with GDF15 and Trp53
 Atf3 recombinant protein  >27 publications with GDF15 and Atf3
 Egfr recombinant protein  >14 publications with GDF15 and Egfr
 Bmpr2 recombinant protein  >3 publications with GDF15 and Bmpr2
 Hfe2 recombinant protein  >3 publications with GDF15 and Hfe2
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >105 publications with GDF15 and Heart Diseases
 Inflammation Antibodies  >105 publications with GDF15 and Inflammation
 Gastrointestinal Neoplasms Antibodies  >74 publications with GDF15 and Gastrointestinal Neoplasms
 Heart Failure Antibodies  >60 publications with GDF15 and Heart Failure
 Prostatic Neoplasms Antibodies  >54 publications with GDF15 and Prostatic Neoplasms
 Brain Diseases Antibodies  >51 publications with GDF15 and Brain Diseases
 Anemia Antibodies  >48 publications with GDF15 and Anemia
 Myocardial Ischemia Antibodies  >43 publications with GDF15 and Myocardial Ischemia
 Necrosis Antibodies  >40 publications with GDF15 and Necrosis
 Nervous System Diseases Antibodies  >37 publications with GDF15 and Nervous System Diseases
Organs/Tissues associated with GDF15 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >92 publications with GDF15 and Bone
 Liver Antibodies  >61 publications with GDF15 and Liver
 Lung Antibodies  >50 publications with GDF15 and Lung
 Muscle Antibodies  >47 publications with GDF15 and Muscle
 Kidney Antibodies  >41 publications with GDF15 and Kidney
 Intestine Antibodies  >17 publications with GDF15 and Intestine
 Connective Tissue Antibodies  >14 publications with GDF15 and Connective Tissue
 Pancreas Antibodies  >6 publications with GDF15 and Pancreas
 Thyroid Antibodies  >4 publications with GDF15 and Thyroid
 Mammary Gland Antibodies  >3 publications with GDF15 and Mammary Gland
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