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GDF3 recombinant protein

Scan QR to view Datasheet Catalog #    MBS538162 GDF3 recombinant protein
Unit / Price
0.02 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GDF3, Recombinant Protein

 Also Known As   

GDF3 protein

 Product Synonym Names    GDF 3 protein; GDF-3 protein; GDF-3; GDF3; Growth/Differentiation Factor-3 protein; GDF 3
 Product Gene Name   

GDF3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    Region of GDF3 protein correspond ing to amino acids AAIPVPKLSC KNLCHRHQLF INFRDLGWHK WIIAPKGFMA NYCHGECPFS LTISLNSSNY AFMQALMHAV DPEIPQAVCI PTKLSPISML YQDNNDNVIL RHYEDMVVDE CGCG.
 OMIM    606522
 3D Structure    ModBase 3D Structure for Q9NR23
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 Host    Human
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 Purity/Purification    = > 98% by SDS-PAGE and HPLC
 Form/Format    Lyophilized powder, 0.2micron sterile filtered from 20mM HCL. Centrifuge vial prior to opening. Reconstitute to a concentration of 0.1-1.0mg/ml and store at 4 degree C for 1 week or -20 degree C for long term. Do not Vortex.
 Concentration    20ug, lyophilized (lot specific)
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 Protein Type    Recombinant
 Biological Significance    GDF-3 is a member of the TGF beta superfamily of growth and differentiation factors, and is highly homologous to GDF-9. Unlike most TGF beta family members, GDF-3 and GDF-9 are not disulfide-linked dimers. GDF-3 is expressed in adult bone marrow, spleen, thymus, and adipose tissue. The expression of GDF-3 is upregulated in high-fat-fed wild-type FABP4/aP2 null mice and was associated with obesity, but not with the related hyperglycemia/hyperinsulinemia which characterizes Type 2 diabetes.
 Bioactivity    Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 100-150 ng/ml.
 Endotoxin Levels    Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
 Expression System    E Coli
 Biohazard    Use standard laboratory procedures when handling this product.
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 Preparation and Storage    Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of GDF3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for GDF3 recombinant protein

   Purified recombinant Human GDF3 protein
 Product Categories/Family for GDF3 recombinant protein    Cytokines & Growth Factors
 Applications Tested/Suitable for GDF3 recombinant protein   

User optimized

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NCBI/Uniprot data below describe general gene information for GDF3. It may not necessarily be applicable to this product.
 NCBI GI #    10190670
 NCBI GeneID    9573
 NCBI Accession #    NP_065685.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_020634.1 [Other Products]
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 UniProt Primary Accession #    Q9NR23 [Other Products]
 UniProt Secondary Accession #    Q8NEJ4 [Other Products]
 UniProt Related Accession #    Q9NR23 [Other Products]
 Molecular Weight    26 kDa
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 NCBI Official Full Name    growth/differentiation factor 3
 NCBI Official Synonym Full Names    growth differentiation factor 3
 NCBI Official Symbol    GDF3 [Similar Products]
 NCBI Official Synonym Symbols   
KFS3; MCOP7; MCOPCB6
[Similar Products]
 NCBI Protein Information    growth/differentiation factor 3
 UniProt Protein Name    Growth/differentiation factor 3
 Protein Family    Growth/differentiation factor
 UniProt Gene Name    GDF3 [Similar Products]
 UniProt Synonym Gene Names    GDF-3 [Similar Products]
 UniProt Entry Name    GDF3_HUMAN
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 NCBI Summary for GDF3    The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GDF3    GDF3: Defects in GDF3 are the cause of Klippel-Feil syndrome type 3 (KFS3); also called Klippel-Feil syndrome autosomal dominant 3. KFS3 is a skeletal disorder characterized by congenital fusion of cervical vertebrae. It is due to a failure in the normal segmentation of vertebrae during the early weeks of fetal development. The clinical triad consists of short neck, low posterior hairline, and limited neck movement. Defects in GDF3 are the cause of microphthalmia isolated with coloboma type 6 (MCOPCB6); also called isolated colobomatous microphthalmia 6. MCOPCB6 is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Defects in GDF3 are a cause of microphthalmia isolated type 7 (MCOP7). MCOP7 is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide; Cytokine

Chromosomal Location of Human Ortholog: 12p13.1

Cellular Component: extracellular space; cytoplasm

Molecular Function: growth factor activity; cytokine activity; protein kinase binding; transforming growth factor beta receptor binding

Biological Process: response to dietary excess; in utero embryonic development; somite rostral/caudal axis specification; notochord development; formation of anatomical boundary; negative regulation of BMP signaling pathway; regulation of apoptosis; eye development; regulation of MAPKKK cascade; regulation of cell fate commitment; negative regulation of epidermal cell differentiation; mesoderm development; negative regulation of myoblast differentiation; skeletal development; cell development; growth; endoderm development

Disease: Microphthalmia, Isolated 7; Klippel-feil Syndrome 3, Autosomal Dominant; Microphthalmia, Isolated, With Coloboma 6
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 Research Articles on GDF3    1. first evidence that NANOG is a transcriptional activator of the expression of the oncogenic growth factor GDF3 in embryonic carcinoma cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GDF3 recombinant proteinDiseases associated with GDF3 recombinant protein
 Reference Product  PubMed Publications
 NANOG recombinant protein  >34 publications with GDF3 and NANOG
 TDGF1 recombinant protein  >11 publications with GDF3 and TDGF1
 DPPA3 recombinant protein  >5 publications with GDF3 and DPPA3
 ACVR1C recombinant protein  >5 publications with GDF3 and ACVR1C
 SMAD2 recombinant protein  >2 publications with GDF3 and SMAD2
 DDX1 recombinant protein  >1 publications with GDF3 and DDX1
 SMAD3 recombinant protein  >1 publications with GDF3 and SMAD3
 PPARG recombinant protein  >1 publications with GDF3 and PPARG
 LEFTY2 recombinant protein  >1 publications with GDF3 and LEFTY2
 LEFTY1 recombinant protein  >1 publications with GDF3 and LEFTY1
 Disease Name  Pubmed Publications
 Neoplasms, Germ Cell and Embryonal Antibodies  >16 publications with GDF3 and Neoplasms, Germ Cell and Embryonal
 Breast Neoplasms Antibodies  >6 publications with GDF3 and Breast Neoplasms
 Congenital Abnormalities Antibodies  >5 publications with GDF3 and Congenital Abnormalities
 Neoplasms, Experimental Antibodies  >3 publications with GDF3 and Neoplasms, Experimental
 Liver Diseases Antibodies  >2 publications with GDF3 and Liver Diseases
 Infertility, Female Antibodies  >2 publications with GDF3 and Infertility, Female
 Disease Models, Animal Antibodies  >2 publications with GDF3 and Disease Models, Animal
 Kidney Diseases Antibodies  >1 publications with GDF3 and Kidney Diseases
 Liver Neoplasms Antibodies  >1 publications with GDF3 and Liver Neoplasms
 Heart Diseases Antibodies  >1 publications with GDF3 and Heart Diseases
Organs/Tissues associated with GDF3 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Mixed Antibodies  >5 publications with GDF3 and Mixed
 Embryonic Tissue Antibodies  >5 publications with GDF3 and Embryonic Tissue
 Testis Antibodies  >5 publications with GDF3 and Testis
 Kidney Antibodies  >1 publications with GDF3 and Kidney
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