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GDNF recombinant protein

Scan QR to view Datasheet Catalog #    MBS539589 GDNF recombinant protein
Unit / Price
0.01 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GDNF, Recombinant Protein

 Also Known As   

GDNF protein

 Product Synonym Names    Glial-Derived Neurotrophic Factor protein; ATF-1 protein
 Product Gene Name   

GDNF recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    Region of GDNF protein correspond ing to amino acids MSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCEAAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDSLV YHILRKHSAK RCGCI.
 OMIM    209880
 3D Structure    ModBase 3D Structure for P39905
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 Host    Human
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 Purity/Purification    > 98% pure
 Form/Format    Supplied as a lyophilized powder.
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 Protein Type    Recombinant
 Biological Significance    GDNF is a disulfide-linked homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFR a(a1-a4) receptors. GDNF specifically promotes dopamine uptake and survival and morphological differentiation of midbrain neurons. Using Parkinson?s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability.
 Bioactivity    Determined by its ability to stimulate the proliferation of rat C6 cells.
 Endotoxin Levels    Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
 Expression System    E Coli
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 Preparation and Storage    Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of GDNF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for GDNF recombinant protein

   Purified recombinant Human GDNF protein
 Product Categories/Family for GDNF recombinant protein    Neuroscience
 Applications Tested/Suitable for GDNF recombinant protein   

User optimized

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NCBI/Uniprot data below describe general gene information for GDNF. It may not necessarily be applicable to this product.
 NCBI GI #    299473781
 NCBI GeneID    2668
 NCBI Accession #    NP_001177398.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001190469.1 [Other Products]
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 UniProt Primary Accession #    P39905 [Other Products]
 UniProt Secondary Accession #    O95448; O95449; O95986; Q6FH33; Q96L44; Q9UD32; Q9UD33; Q9UMV2; Q9UP67; Q9UP97; B7WPK7 [Other Products]
 UniProt Related Accession #    P39905; AAB33493; AAB33494 [Other Products]
 Molecular Weight    18,123 Da
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 NCBI Official Full Name    glial cell line-derived neurotrophic factor isoform 4 preproprotein
 NCBI Official Synonym Full Names    glial cell derived neurotrophic factor
 NCBI Official Symbol    GDNF [Similar Products]
 NCBI Official Synonym Symbols   
ATF1; ATF2; HSCR3; HFB1-GDNF
[Similar Products]
 NCBI Protein Information    glial cell line-derived neurotrophic factor
 UniProt Protein Name    Glial cell line-derived neurotrophic factor
 UniProt Synonym Protein Names   
Astrocyte-derived trophic factor; ATF
 Protein Family    GDNF family receptor
 UniProt Gene Name    GDNF [Similar Products]
 UniProt Synonym Gene Names    hGDNF; ATF [Similar Products]
 UniProt Entry Name    GDNF_HUMAN
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 NCBI Summary for GDNF    This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease. [provided by RefSeq, Jun 2010]
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 UniProt Comments for GDNF    GDNF: Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. Defects in GDNF may be a cause of Hirschsprung disease type 3 (HSCR3). In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS); also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. Belongs to the TGF-beta family. GDNF subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 5p13.1-p12

Cellular Component: extracellular region

Molecular Function: protein homodimerization activity; growth factor activity; receptor binding

Biological Process: positive regulation of dopamine secretion; nervous system development; axon guidance; peristalsis; adult locomotory behavior; mRNA stabilization; regulation of dopamine uptake; positive regulation of monooxygenase activity; signal transduction; enteric nervous system development; sympathetic nervous system development; regulation of gene expression; ureteric bud branching; induction of an organ; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; postganglionic parasympathetic nervous system development; negative regulation of neuron apoptosis; postsynaptic membrane organization; positive regulation of cell differentiation; neural crest cell migration; metanephros development; neurite development; negative regulation of apoptosis

Disease: Hirschsprung Disease, Susceptibility To, 3; Central Hypoventilation Syndrome, Congenital; Pheochromocytoma
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 Research Articles on GDNF    1. Study found association between single nucleotide polymorphisms in the regulatory sites of Glial Derived Neurotrophic Factor (GDNF) and bipolar disorder.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with GDNF recombinant proteinDiseases associated with GDNF recombinant protein
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 NCAM Signaling For Neurite Out-growth Pathway antibodies  NCAM Signaling For Neurite Out-growth Pathway Diagram
 NCAM1 Interactions Pathway antibodies  NCAM1 Interactions Pathway Diagram
 Signaling Events Regulated By Ret Tyrosine Kinase Pathway antibodies  Signaling Events Regulated By Ret Tyrosine Kinase Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1438 publications with GDNF and Nervous System Diseases
 Neurodegenerative Diseases Antibodies  >636 publications with GDNF and Neurodegenerative Diseases
 Disease Models, Animal Antibodies  >591 publications with GDNF and Disease Models, Animal
 Movement Disorders Antibodies  >568 publications with GDNF and Movement Disorders
 Parkinsonian Disorders Antibodies  >532 publications with GDNF and Parkinsonian Disorders
 Parkinson Disease Antibodies  >468 publications with GDNF and Parkinson Disease
 Nerve Degeneration Antibodies  >283 publications with GDNF and Nerve Degeneration
 Neurologic Manifestations Antibodies  >202 publications with GDNF and Neurologic Manifestations
 Inflammation Antibodies  >177 publications with GDNF and Inflammation
 Brain Injuries Antibodies  >158 publications with GDNF and Brain Injuries
Organs/Tissues associated with GDNF recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2081 publications with GDNF and Brain
 Embryonic Tissue Antibodies  >381 publications with GDNF and Embryonic Tissue
 Muscle Antibodies  >289 publications with GDNF and Muscle
 Bone Antibodies  >215 publications with GDNF and Bone
 Skin Antibodies  >77 publications with GDNF and Skin
 Ovary Antibodies  >20 publications with GDNF and Ovary
 Placenta Antibodies  >5 publications with GDNF and Placenta
 Uncharacterized Tissue Antibodies  >1 publications with GDNF and Uncharacterized Tissue
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