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GLRX5 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203623
SDS-PAGE
Unit / Price
0.1 mg  /  $285 +1 FREE 8GB USB
0.5 mg  /  $640 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GLRX5, Recombinant Protein

 Also Known As   

GLRX5, 1-157aa, Human, His tag, E Coli

 Product Synonym Names    C14orf87; GRX5; Glutaredoxin-related protein 5; mitochondrial Chromosome 14 open reading frame 87; FLB4739; GLRX 5; Glutaredoxin 5 homolog; Glutaredoxin related protein 5; Glutaredoxin5; GRX5; MGC14129; PRO1238.
 Product Gene Name   

GLRX5 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MSGSLGRAAA ALLRWGRGAG GGGLWGPGVR AAGSGAGGGG SAEQLDALVK KDKVVVFLKG TPEQPQCGFS NAVVQILRLH GVRDYAAYNV LDDPELRQGI KDYSNWPTIP QVYLNGEFVG GCDILLQMHQ NGDLVEELKK LGIHSALLDE KKDQDSK
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 Purity/Purification    > 85% by SDS - PAGE
 Form/Format    Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 0.1M NaCl
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag    His-tag
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of GLRX5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for GLRX5 recombinant protein

   GLRX5 is small redox enzymes of approximately one hundred amino-acid residues which uses glutathione as a cofactor. This protein is oxidized by substrates, and reduced non-enzymatically by glutathione. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Recombinant human GLRX5 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques
 Product Categories/Family for GLRX5 recombinant protein    Redox Proteins
 Applications Tested/Suitable for GLRX5 recombinant protein   

SDS-PAGE

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 SDS-PAGE of GLRX5 recombinant protein    GLRX5 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for GLRX5. It may not necessarily be applicable to this product.
 NCBI GI #    42516576
 NCBI GeneID    51218
 NCBI Accession #    NP_057501 [Other Products]
 NCBI GenBank Nucleotide #    NM_016417.2 [Other Products]
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 UniProt Secondary Accession #    Q0X088; Q3YML0; Q86WY3; Q8IZ54 [Other Products]
 UniProt Related Accession #    Q86SX6 [Other Products]
 Molecular Weight    18.8 kDa (177aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    glutaredoxin-related protein 5, mitochondrial
 NCBI Official Synonym Full Names    glutaredoxin 5
 NCBI Official Symbol    GLRX5 [Similar Products]
 NCBI Official Synonym Symbols   
GRX5; PRSA; FLB4739; PR01238; PRO1238; C14orf87
[Similar Products]
 NCBI Protein Information    glutaredoxin-related protein 5, mitochondrial; glutaredoxin 5 homolog; monothiol glutaredoxin-5
 UniProt Protein Name    Glutaredoxin-related protein 5, mitochondrial
 UniProt Synonym Protein Names   
Monothiol glutaredoxin-5
 Protein Family    Glutaredoxin-related protein
 UniProt Gene Name    GLRX5 [Similar Products]
 UniProt Synonym Gene Names    C14orf87 [Similar Products]
 UniProt Entry Name    GLRX5_HUMAN
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 NCBI Summary for GLRX5    This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, May 2010]
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 UniProt Comments for GLRX5    GLRX5: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1. Defects in GLRX5 are a cause of anemia sideroblastic pyridoxine-refractory autosomal recessive (PRARSA). A form of sideroblastic anemia not responsive to pyridoxine. Sideroblastic anemia is characterized by anemia of varying severity, hypochromic peripheral erythrocytes, systemic iron overload secondary to chronic ineffective erythropoiesis, and the presence of bone marrow ringed sideroblasts. Sideroblasts are characterized by iron-loaded mitochondria clustered around the nucleus. Belongs to the glutaredoxin family. Monothiol subfamily.

Protein type: Oxidoreductase

Chromosomal Location of Human Ortholog: 14q32.13

Cellular Component: mitochondrion; nucleus

Molecular Function: 2 iron, 2 sulfur cluster binding; electron carrier activity; metal ion binding; protein disulfide oxidoreductase activity

Biological Process: cell redox homeostasis; hemopoiesis

Disease: Anemia, Sideroblastic, Pyridoxine-refractory, Autosomal Recessive
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Product References and Citations for GLRX5 recombinant protein

   Holmgren A., et al. (1988) FEMS Microbiol. Rev. 4 (4): 271-297.
Holmgren A., et al. (1988) Biochem. Soc. Trans. 16 (2): 95-96.
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 Research Articles on GLRX5    1. Patients with GLRX5-associated variant nonketotic hyperglycemia had normal development with childhood-onset spastic paraplegia, spinal lesion, and optic atrophy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GLRX5 recombinant proteinDiseases associated with GLRX5 recombinant protein
 Reference Product  PubMed Publications
 ALAS2 recombinant protein  >11 publications with GLRX5 and ALAS2
 ABCB7 recombinant protein  >8 publications with GLRX5 and ABCB7
 SLC25A38 recombinant protein  >6 publications with GLRX5 and SLC25A38
 BOLA3 recombinant protein  >2 publications with GLRX5 and BOLA3
 ISCU recombinant protein  >2 publications with GLRX5 and ISCU
 GLRX2 recombinant protein  >2 publications with GLRX5 and GLRX2
 Disease Name  Pubmed Publications
 Anemia Antibodies  >14 publications with GLRX5 and Anemia
 Anemia, Sideroblastic Antibodies  >12 publications with GLRX5 and Anemia, Sideroblastic
 Musculoskeletal Diseases Antibodies  >2 publications with GLRX5 and Musculoskeletal Diseases
 Atrophy Antibodies  >1 publications with GLRX5 and Atrophy
 Inflammation Antibodies  >1 publications with GLRX5 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >1 publications with GLRX5 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >1 publications with GLRX5 and Liver Diseases
 Adenocarcinoma Antibodies  >1 publications with GLRX5 and Adenocarcinoma
 Liver Neoplasms Antibodies  >1 publications with GLRX5 and Liver Neoplasms
 Hypertrophy Antibodies  >1 publications with GLRX5 and Hypertrophy
Organs/Tissues associated with GLRX5 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >6 publications with GLRX5 and Bone
 Bone Marrow Antibodies  >6 publications with GLRX5 and Bone Marrow
 Brain Antibodies  >2 publications with GLRX5 and Brain
 Liver Antibodies  >1 publications with GLRX5 and Liver
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