NP_057501
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
18.8 kDa (177aa), confirmed by MALDI-TOF
NCBI Official Full Name
glutaredoxin-related protein 5, mitochondrial
NCBI Official Synonym Full Names
glutaredoxin 5
NCBI Official Synonym Symbols
GRX5; PRSA; SIDBA3; SPAHGC; FLB4739; PR01238; PRO1238; C14orf87 [Similar Products]
NCBI Protein Information
glutaredoxin-related protein 5, mitochondrial
UniProt Protein Name
Glutaredoxin-related protein 5, mitochondrial
UniProt Synonym Protein Names
Monothiol glutaredoxin-5
UniProt Synonym Gene Names
NCBI Summary for GLRX5
This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, May 2010]
UniProt Comments for GLRX5
Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (PubMed:20364084). Involved in protein lipoylation, acting in the pathway that provides an iron-sulfur cluster to lipoate synthase (PubMed:24334290). Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (PubMed:20364084). May protect cells against apoptosis due to reactive oxygen species and oxidative stress ().
Product References and Citations for GLRX5 recombinant protein
Holmgren A., et al. (1988) FEMS Microbiol. Rev. 4 (4): 271-297.; Holmgren A., et al. (1988) Biochem. Soc. Trans. 16 (2): 95-96.;
Research Articles on GLRX5
Precautions
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Disclaimer
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Products associated with GLRX5 recombinant protein
Diseases associated with GLRX5 recombinant protein
Disease Name |
Pubmed Publications |
Anemia Antibodies |
>15 publications with GLRX5 and Anemia |
Anemia, Sideroblastic Antibodies |
>13 publications with GLRX5 and Anemia, Sideroblastic |
Fibrosis Antibodies |
>2 publications with GLRX5 and Fibrosis |
Inflammation Antibodies |
>2 publications with GLRX5 and Inflammation |
Carcinoma, Hepatocellular Antibodies |
>1 publications with GLRX5 and Carcinoma, Hepatocellular |
Liver Neoplasms Antibodies |
>1 publications with GLRX5 and Liver Neoplasms |
Adenocarcinoma Antibodies |
>1 publications with GLRX5 and Adenocarcinoma |
Liver Diseases Antibodies |
>1 publications with GLRX5 and Liver Diseases |
Hypertrophy Antibodies |
>1 publications with GLRX5 and Hypertrophy |
Anemia, Sideroblastic, Pyridoxine-Refractory, Autosomal Recessive Antibodies |
>1 publications with GLRX5 and Anemia, Sideroblastic, Pyridoxine-Refractory, Autosomal Recessive |
Organs/Tissues associated with GLRX5 recombinant protein
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