Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow GLuD1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Trypsin Recombinant Protein
 • MAP4K3 Antibody
 • A Disintegrin and Metalloprotease 11 (ADAM11) ELISA Kit
 • NGAL-MMP-9 complex ELISA Kit
 • Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) ELISA Kit
 • Endotoxin (EDT) ELISA Kit
 • GSDMD cDNA Clone
 • PELI3 Antibody
 • ACTH [1-24] Antibody
 • FABP3 ELISA Kit
 • Vimentin Native Protein
 • NLR family, pyrin domain containing 2 (NLRP2) ELISA Kit
 • CytoSelect 96-well In Vitro Tumor Sensitivity Assay (Soft Ag... Assay Kit
 • Leptin Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

GLuD1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS205535
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GLuD1, Recombinant Protein

★Popular Item★
 Also Known As   

GLuD1, 54-558aa, Human, His tag, E Coli (Denatured)

 Product Synonym Names    Glutamate dehydrogenase 1 mitochondrial; Glutamate dehydrogenase 1; mitochondrial; GDH; GDH1; GLuD
 Product Gene Name   

GLuD1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence    MGSSHHHHHH SSGLVPRGSH MGSSEAVADR EDDPNFFKMV EGFFDRGASI VEDKLVEDLR TRESEEQKRN RVRGILRIIK PCNHVLSLSF PIRRDDGSWE VIEGYRAQHS QHRTPCKGGI RYSTDVSVDE VKALASLMTY KCAVVDVPFG GAKAGVKINP KNYTDNELEK ITRRFTMELA KKGFIGPGID VPAPDMSTGE REMSWIADTY ASTIGHYDIN AHACVTGKPI SQGGIHGRIS ATGRGVFHGI ENFINEASYM SILGMTPGFG DKTFVVQGFG NVGLHSMRYL HRFGAKCIAV GESDGSIWNP DGIDPKELED FKLQHGSILG FPKAKPYEGS ILEADCDILI PAASEKQLTK SNAPRVKAKI IAEGANGPTT PEADKIFLER NIMVIPDLYL NAGGVTVSYF EWLKNLNHVS YGRLTFKYER DSNYHLLMSV QESLERKFGK HGGTIPIVPT AEFQDRISGA SEKDIVHSGL AYTMERSARQ IMRTAMKYNL GLDLRTAAYV NAIEKVFKVY NEAGVTFT
 OMIM    X07674 mRNA
 3D Structure    ModBase 3D Structure for P00367
Section Bar
 Host    E Coli
Section Bar
 Purity/Purification    > 80% by SDS-PAGE
 Form/Format    Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.4M urea, 10% glycerol
 Concentration    1mg/ml (determined by Bradford assay) (lot specific)
Section Bar
 Antigen Species    Human
 Tag Information    His-tag
Section Bar
 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of GLuD1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for GLuD1 recombinant protein

   Glutamate dehydrogenase 1, mitochondrial precursor, also known as GLuD1, belongs to the Glu/Leu/Phe/Val dehydrogenases family. GLuD1 has a central role in nitrogen metabolism in plants and animals. GLuD1 is found in all organisms and catalyzes the oxidative deamination of 1-glutamate to 2-oxoglutarate. Mutations in the gene encoding GLuD1 causes hyperinsulinism-hyperammonemia syndrome (HHS), which is an inherited condition characterized by high insulin and ammonia levels in the blood. GLuD1 may also be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. Recombinant human GLuD1 protein, fused to His-tag at N-terminus, was expressed in E Coli.
 Product Categories/Family for GLuD1 recombinant protein    Metabolism
 Applications Tested/Suitable for GLuD1 recombinant protein   

SDS-PAGE

Section Bar
 SDS-Page of GLuD1 recombinant protein    GLuD1 recombinant protein SDS-Page image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for GLuD1. It may not necessarily be applicable to this product.
 NCBI GI #    4885281
 NCBI GeneID    2746
 NCBI Accession #    NP_005262 [Other Products]
 NCBI GenBank Nucleotide #    NM_005271.4 [Other Products]
Section Bar
 UniProt Primary Accession #    P00367 [Other Products]
 UniProt Secondary Accession #    Q5TBU3; B3KV55; B4DGN5 [Other Products]
 UniProt Related Accession #    P00367 [Other Products]
 Molecular Weight    58.4 kDa (528aa)
Table BarTOPTable Bar
 NCBI Official Full Name    glutamate dehydrogenase 1, mitochondrial isoform a
 NCBI Official Synonym Full Names    glutamate dehydrogenase 1
 NCBI Official Symbol    GLUD1 [Similar Products]
 NCBI Official Synonym Symbols   
GDH; GDH1; GLUD
[Similar Products]
 NCBI Protein Information    glutamate dehydrogenase 1, mitochondrial
 UniProt Protein Name    Glutamate dehydrogenase 1, mitochondrial
 UniProt Gene Name    GLUD1 [Similar Products]
 UniProt Synonym Gene Names    GLUD; GDH 1 [Similar Products]
Section Bar
 NCBI Summary for GLuD1    This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X. [provided by RefSeq, Jan 2016]
Section Bar
 UniProt Comments for GLuD1    Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate ().
Table BarTOPTable Bar
 

Product References and Citations for GLuD1 recombinant protein

   Mastorodemos V., et al. (2009) Biochem Cell Biol. 87:505-516.; Tanizawa Y., et al. (2002) Diabetes. 51:712-717.;
Section Bar
 Research Articles on GLuD1    1. the present study shows that the GDHS445L enzyme is highly sensitive to the allosteric activator ADP, explaining the hyperactivity of this mutant. INS-1E beta-cells expressing GDHS445L responded to glutamine stimulation by increasing the mitochondrial respiration and ATP production, as well as by a rise in cytosolic calcium.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with GLuD1 recombinant proteinPathways associated with GLuD1 recombinant protein
 Reference Product  PubMed Publications
 CPS1 recombinant protein  >4 publications with GLuD1 and CPS1
 GOT1 recombinant protein  >4 publications with GLuD1 and GOT1
 GLUL recombinant protein  >4 publications with GLuD1 and GLUL
 IDH1 recombinant protein  >1 publications with GLuD1 and IDH1
 GPT2 recombinant protein  >1 publications with GLuD1 and GPT2
 GOT2 recombinant protein  >1 publications with GLuD1 and GOT2
 Products by Pathway  Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Amino Acid Metabolism Pathway antibodies  Amino Acid Metabolism Pathway Diagram
 Amino Acid Synthesis And Interconversion (transamination) Pathway antibodies  Amino Acid Synthesis And Interconversion (transamination) Pathway Diagram
 Arginine Biosynthesis Pathway antibodies  Arginine Biosynthesis Pathway Diagram
 Arginine Biosynthesis Pathway antibodies  Arginine Biosynthesis Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 D-Glutamine And D-glutamate Metabolism Pathway antibodies  D-Glutamine And D-glutamate Metabolism Pathway Diagram
 D-Glutamine And D-glutamate Metabolism Pathway antibodies  D-Glutamine And D-glutamate Metabolism Pathway Diagram
Diseases associated with GLuD1 recombinant proteinOrgans/Tissues associated with GLuD1 recombinant protein
 Disease Name  Pubmed Publications
 Hyperinsulinism Antibodies  >79 publications with GLuD1 and Hyperinsulinism
 Hyperammonemia Antibodies  >36 publications with GLuD1 and Hyperammonemia
 Seizures Antibodies  >18 publications with GLuD1 and Seizures
 Hyperinsulinemic hypoglycemia, familial, 6 Antibodies  >10 publications with GLuD1 and Hyperinsulinemic hypoglycemia, familial, 6
 Liver Diseases Antibodies  >7 publications with GLuD1 and Liver Diseases
 Hyperplasia Antibodies  >5 publications with GLuD1 and Hyperplasia
 Inflammation Antibodies  >4 publications with GLuD1 and Inflammation
 Neurobehavioral Manifestations Antibodies  >4 publications with GLuD1 and Neurobehavioral Manifestations
 Movement Disorders Antibodies  >4 publications with GLuD1 and Movement Disorders
 Poisoning Antibodies  >4 publications with GLuD1 and Poisoning
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >73 publications with GLuD1 and Brain
 Blood Antibodies  >32 publications with GLuD1 and Blood
 Pancreas Antibodies  >24 publications with GLuD1 and Pancreas
 Liver Antibodies  >21 publications with GLuD1 and Liver
 Nerve Antibodies  >18 publications with GLuD1 and Nerve
 Testis Antibodies  >9 publications with GLuD1 and Testis
 Kidney Antibodies  >7 publications with GLuD1 and Kidney
 Placenta Antibodies  >4 publications with GLuD1 and Placenta
 Embryonic Tissue Antibodies  >3 publications with GLuD1 and Embryonic Tissue
 Vascular Antibodies  >3 publications with GLuD1 and Vascular
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions