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GM-CSF recombinant protein

Scan QR to view Datasheet Catalog #    MBS232465 GM-CSF recombinant protein
Unit / Price
0.02 mg  /  $440 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GM-CSF, Recombinant Protein

★Popular Item★
 Also Known As   

RECOMBINANT MOUSE GM-CSF

 Product Gene Name   

GM-CSF recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P01587
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 Purity/Purification    >98% by SDS PAGE and HPLC analysis
 Form/Format    Purified recombinant protein - lyophilised
 Concentration    Approximate Protein Concentration: 0.1 mg/ml after reconstitution (lot specific)
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 Reconstitution    Reconstitute with 0.2ml distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution.
Preparation
 Buffer Solution    10mM Acetic Acid
 Activity    The ED50 as determined by the dose-dependent stimulation of the proliferation of murine FDC-P1 cells is = 0.05 ng/ml, corresponding to a specific activity of = 2 x 107 units/mg.
 Target Species    Mouse
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 Preparation and Storage    Prior to reconstitution store at 4 degree C. Following reconstitution store at -20 degree C. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 3 months from date of reconstitution.
 Other Notes    Small volumes of GM-CSF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for GM-CSF recombinant protein

   GM-CSF (granulocyte-macrophage colony-stimulating factor) is a haematopoietic growth factor which exists in both glycosylated and non-glycosylated biologically active forms, and stimulates the development of granulocytes, macrophages, early megakaryocytes and eosinophil progenitor cells. The ability of recombinant GM-CSF to increase haematopoietic cell recovery has become a focus area in the therapeutic treatment of patients following bone marrow transplantation.
 Applications Tested/Suitable for GM-CSF recombinant protein   

ELISA (EIA), Functional Assays (FN), Western Blot (WB)

 Application Notes for GM-CSF recombinant protein    ELISA: Minimum Dilution: 0.2; Maximum Dilution: 0.4ng/well;
Western Blotting: Minimum Dilution: 1.5; Maximum Dilution: 3.0ng/lane
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NCBI/Uniprot data below describe general gene information for GM-CSF. It may not necessarily be applicable to this product.
 NCBI GI #    110625658
 NCBI GeneID    12981
 NCBI Accession #    NP_034099.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_009969.4 [Other Products]
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 UniProt Primary Accession #    P01587 [Other Products]
 UniProt Related Accession #    P01587 [Other Products]
 Molecular Weight    Protein Molecular Weight: 14.2kDa (124 amino acid residues)
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 NCBI Official Full Name    granulocyte-macrophage colony-stimulating factor
 NCBI Official Synonym Full Names    colony stimulating factor 2 (granulocyte-macrophage)
 NCBI Official Symbol    Csf2 [Similar Products]
 NCBI Official Synonym Symbols   
Csfgm; GMCSF; Gm-CSf; MGI-IGM
[Similar Products]
 NCBI Protein Information    granulocyte-macrophage colony-stimulating factor; CSF; granulocyte-macrophage colony stimulating factor 2; put. GM-CSF
 UniProt Protein Name    Granulocyte-macrophage colony-stimulating factor
 UniProt Synonym Protein Names   
Colony-stimulating factor; CSF
 UniProt Gene Name    Csf2 [Similar Products]
 UniProt Synonym Gene Names    Csfgm; GM-CSF; CSF [Similar Products]
 UniProt Entry Name    CSF2_MOUSE
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 UniProt Comments for GM-CSF    GMCSF: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Belongs to the GM-CSF family.

Protein type: Secreted, signal peptide; Secreted; Cytokine

Cellular Component: extracellular space; extracellular region

Molecular Function: growth factor activity; granulocyte macrophage colony-stimulating factor receptor binding; cytokine activity

Biological Process: negative regulation of cytolysis; epithelial fluid transport; macrophage activation; embryonic placenta development; positive regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of interleukin-23 production; regulation of gene expression; positive regulation of cell proliferation; immune response; myeloid dendritic cell differentiation; positive regulation of DNA replication; regulation of cell proliferation
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 Research Articles on GM-CSF    1. Expression of PPAR-gamma in fetal lung monocytes was dependent on the cytokine GM-CSF. Therefore, GM-CSF has a lung-specific role in the perinatal development of alveolar macrophages through the induction of PPAR-gamma in fetal monocytes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with GM-CSF recombinant proteinDiseases associated with GM-CSF recombinant protein
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response (BioCarta) Pathway antibodies  Cytokines And Inflammatory Response (BioCarta) Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
 G Beta:gamma Signalling Through PI3Kgamma Pathway antibodies  G Beta:gamma Signalling Through PI3Kgamma Pathway Diagram
 G-protein Beta:gamma Signalling Pathway antibodies  G-protein Beta:gamma Signalling Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >41 publications with GM-CSF and Inflammation
 Necrosis Antibodies  >26 publications with GM-CSF and Necrosis
 Lung Diseases Antibodies  >9 publications with GM-CSF and Lung Diseases
 Breast Neoplasms Antibodies  >7 publications with GM-CSF and Breast Neoplasms
 Fibrosis Antibodies  >4 publications with GM-CSF and Fibrosis
 Neoplasms, Experimental Antibodies  >4 publications with GM-CSF and Neoplasms, Experimental
 Carcinoma Antibodies  >3 publications with GM-CSF and Carcinoma
 Leukemia, Myeloid, Acute Antibodies  >3 publications with GM-CSF and Leukemia, Myeloid, Acute
 Arthritis, Rheumatoid Antibodies  >3 publications with GM-CSF and Arthritis, Rheumatoid
 Lung Neoplasms Antibodies  >3 publications with GM-CSF and Lung Neoplasms
Organs/Tissues associated with GM-CSF recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >12 publications with GM-CSF and Lung
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