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GRB2 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203275
SDS-PAGE
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GRB2, Recombinant Protein

★Popular Item★
 Also Known As   

GRB2, 1-217aa, Human, His-tag, Recombinant, E Coli

 Product Synonym Names    Growth factor receptor-bound protein 2 isoform 1; ASH; EGFRBP-GRB2; GRB3-3; Growth factor receptor-bound protein 2 isoform 1 Abundant SRC homology; Adapter protein GRB2; Ash protein; EGFRBP GRB2; Epidermal growth factor receptor binding protein; Epidermal growth factor receptor binding protein GRB2; GRB 2; GRB2 adapter protein; Grb3 3; Growth factor receptor bound protein 2; Growth factor receptor bound protein 3; HT027; MST084; MSTP084; OTTHuMP00000166096; OTTHuMP00000166097; OTTHuMP00000166098; Protein ASH; SEM5; SH2/SH3 adapter GRB2.
 Product Gene Name   

GRB2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQQPTY VQALFDFDPQ EDGELGFRRG DFIHVMDNSD PNWWKGACHG QTGMFPRNYV TPVNRNV
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 Purity/Purification    > 95% by SDS - PAGE
 Form/Format    In 20mM Tris-HCl (pH8.0) buffer containing 30% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag    His-tag
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of GRB2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for GRB2 recombinant protein

   Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. GRB2 is widely expressed and also binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Grb2 is composed of an SH2 domain flanked on each side by an SH3 domain. Inhibition of Grb2 function impairs developmental processes in various organisms and blocks transformation and proliferation of various cell types. Recombinant human GRB2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
 Product Categories/Family for GRB2 recombinant protein    Signal Transduction
 Applications Tested/Suitable for GRB2 recombinant protein   

SDS-PAGE

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 SDS-PAGE of GRB2 recombinant protein    GRB2 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for GRB2. It may not necessarily be applicable to this product.
 NCBI GI #    4504111
 NCBI GeneID    2885
 NCBI Accession #    NP_002077 [Other Products]
 NCBI GenBank Nucleotide #    NM_002086.4 [Other Products]
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 UniProt Secondary Accession #    P29354; Q14450; Q63057; Q63059 [Other Products]
 UniProt Related Accession #    P62993 [Other Products]
 Molecular Weight    27 kDa (237 aa), confirmed by MALDI-TOF.
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 NCBI Official Full Name    growth factor receptor-bound protein 2 isoform 1
 NCBI Official Synonym Full Names    growth factor receptor-bound protein 2
 NCBI Official Symbol    GRB2 [Similar Products]
 NCBI Official Synonym Symbols   
ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2
[Similar Products]
 NCBI Protein Information    growth factor receptor-bound protein 2; HT027; SH2/SH3 adapter GRB2; abundant SRC homology; epidermal growth factor receptor-binding protein GRB2; growth factor receptor-bound protein 3; protein Ash
 UniProt Protein Name    Growth factor receptor-bound protein 2
 UniProt Synonym Protein Names   
Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2
 Protein Family    GRB2-related adapter protein
 UniProt Gene Name    GRB2 [Similar Products]
 UniProt Synonym Gene Names    ASH [Similar Products]
 UniProt Entry Name    GRB2_HUMAN
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 NCBI Summary for GRB2    The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GRB2    Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
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Product References and Citations for GRB2 recombinant protein

   Rudd CE., et al. (2009) Immunol Rev. 229(1):12-26.
Weisswange I., et al. (2009) Nature. 458(7234):87-91.
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 Research Articles on GRB2    1. these results identify Grb2 and Shc as central signaling effectors of Met-driven progression of intestinal epithelial-derived cancers. Notably, they suggest that Grb2 may represent a promising target for the design of novel colorectal cancer therapies.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GRB2 recombinant proteinPathways associated with GRB2 recombinant protein
 Reference Product  PubMed Publications
 EGFR recombinant protein  >263 publications with GRB2 and EGFR
 GAB1 recombinant protein  >203 publications with GRB2 and GAB1
 CBL recombinant protein  >172 publications with GRB2 and CBL
 IRS1 recombinant protein  >138 publications with GRB2 and IRS1
 SOS1 recombinant protein  >134 publications with GRB2 and SOS1
 GAB2 recombinant protein  >128 publications with GRB2 and GAB2
 ERBB2 recombinant protein  >109 publications with GRB2 and ERBB2
 LAT recombinant protein  >102 publications with GRB2 and LAT
 FRS2 recombinant protein  >40 publications with GRB2 and FRS2
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Diseases associated with GRB2 recombinant proteinOrgans/Tissues associated with GRB2 recombinant protein
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >107 publications with GRB2 and Breast Neoplasms
 Adenocarcinoma Antibodies  >49 publications with GRB2 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >46 publications with GRB2 and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >42 publications with GRB2 and Cardiovascular Diseases
 Inflammation Antibodies  >40 publications with GRB2 and Inflammation
 Insulin Resistance Antibodies  >37 publications with GRB2 and Insulin Resistance
 Liver Diseases Antibodies  >31 publications with GRB2 and Liver Diseases
 Liver Neoplasms Antibodies  >28 publications with GRB2 and Liver Neoplasms
 Lung Neoplasms Antibodies  >27 publications with GRB2 and Lung Neoplasms
 Necrosis Antibodies  >25 publications with GRB2 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >458 publications with GRB2 and Blood
 Muscle Antibodies  >154 publications with GRB2 and Muscle
 Nerve Antibodies  >144 publications with GRB2 and Nerve
 Brain Antibodies  >137 publications with GRB2 and Brain
 Vascular Antibodies  >123 publications with GRB2 and Vascular
 Liver Antibodies  >99 publications with GRB2 and Liver
 Bone Antibodies  >97 publications with GRB2 and Bone
 Kidney Antibodies  >81 publications with GRB2 and Kidney
 Lung Antibodies  >80 publications with GRB2 and Lung
 Bone Marrow Antibodies  >67 publications with GRB2 and Bone Marrow
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