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GREM2 recombinant protein

Scan QR to view Datasheet Catalog #    MBS204949
SDS-PAGE
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GREM2, Recombinant Protein

 Also Known As   

GREM2, 22-168aa, Human, His tag, E Coli

 Product Synonym Names    Gremlin-2 precursor; CKTSF1B2; DAND3; PRDC
 Product Gene Name   

GREM2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MGSRKNRPAG AIPSPYKDGS SNNSERWQHQ IKEVLASSQE ALVVTERKYL KSDWCKTQPL RQTVSEEGCR SRTILNRFCY GQCNSFYIPR HVKKEEESFQ SCAFCKPQRV TSVLVELECP GLDPPFRLKK IQKVKQCRCM SVNLSDSDKQ
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 Purity/Purification    > 85% by SDS - PAGE
 Form/Format    Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag    His-tag
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of GREM2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for GREM2 recombinant protein

   GREM2 is a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this protein belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this protein may play a role in regulating organogenesis, body patterning, and tissue differentiation. Recombinant human GREM2 protein, fused to His-tag at N-terminus, was expressed in E.coli.
 Product Categories/Family for GREM2 recombinant protein    Signal Transduction
 Applications Tested/Suitable for GREM2 recombinant protein   

SDS-PAGE

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 SDS-PAGE of GREM2 recombinant protein    GREM2 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for GREM2. It may not necessarily be applicable to this product.
 NCBI GI #    71164892
 NCBI GeneID    64388
 NCBI Accession #    NP_071914 [Other Products]
 NCBI GenBank Nucleotide #    NM_022469.3 [Other Products]
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 UniProt Secondary Accession #    Q86UD9 [Other Products]
 UniProt Related Accession #    Q9H772 [Other Products]
 Molecular Weight    19 kDa (170aa)
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 NCBI Official Full Name    gremlin-2
 NCBI Official Synonym Full Names    gremlin 2, DAN family BMP antagonist
 NCBI Official Symbol    GREM2 [Similar Products]
 NCBI Official Synonym Symbols   
PRDC; DAND3; CKTSF1B2
[Similar Products]
 NCBI Protein Information    gremlin-2; DAN domain family member 3; cysteine knot superfamily 1, BMP antagonist 2; gremlin 2, cysteine knot superfamily, homolog; protein related to DAN and cerberus
 UniProt Protein Name    Gremlin-2
 UniProt Synonym Protein Names   
Cysteine knot superfamily 1, BMP antagonist 2; DAN domain family member 3; Protein related to DAN and cerberus
 Protein Family    Gremlin
 UniProt Gene Name    GREM2 [Similar Products]
 UniProt Synonym Gene Names    CKTSF1B2; DAND3; PRDC [Similar Products]
 UniProt Entry Name    GREM2_HUMAN
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 NCBI Summary for GREM2    This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GREM2    GREM2: Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner. Antagonized BMP4-induced suppression of progesterone production in granulosa cells. Belongs to the DAN family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q43

Cellular Component: extracellular space; extracellular region

Molecular Function: heparin binding; protein homodimerization activity; cytokine activity

Biological Process: BMP signaling pathway; embryonic body morphogenesis; cytokine and chemokine mediated signaling pathway; determination of dorsal identity
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Product References and Citations for GREM2 recombinant protein

   Sudo S, et al. (2004). J Biol Chem. 279(22):23134-41.
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 Research Articles on GREM2    1. The minor allele of rs4454537 is significantly associated with low bone density at the total hip of southern Chinese people. Our study further suggests GREM2 as a novel susceptibility gene for osteoporosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GREM2 recombinant proteinPathways associated with GREM2 recombinant protein
 Reference Product  PubMed Publications
 BMP4 recombinant protein  >8 publications with GREM2 and BMP4
 BMP2 recombinant protein  >8 publications with GREM2 and BMP2
 CER1 recombinant protein  >5 publications with GREM2 and CER1
 GDF5 recombinant protein  >2 publications with GREM2 and GDF5
 BMP7 recombinant protein  >1 publications with GREM2 and BMP7
 GDF9 recombinant protein  >1 publications with GREM2 and GDF9
 CHRDL1 recombinant protein  >1 publications with GREM2 and CHRDL1
 NOG recombinant protein  >1 publications with GREM2 and NOG
 Products by Pathway  Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By BMP Pathway antibodies  Signaling By BMP Pathway Diagram
Diseases associated with GREM2 recombinant proteinOrgans/Tissues associated with GREM2 recombinant protein
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >3 publications with GREM2 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >2 publications with GREM2 and Cardiovascular Diseases
 Vascular Diseases Antibodies  >1 publications with GREM2 and Vascular Diseases
 Brain Diseases Antibodies  >1 publications with GREM2 and Brain Diseases
 Neoplasm Metastasis Antibodies  >1 publications with GREM2 and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >1 publications with GREM2 and Adenocarcinoma
 Pain Antibodies  >1 publications with GREM2 and Pain
 Liver Neoplasms Antibodies  >1 publications with GREM2 and Liver Neoplasms
 Weight Loss Antibodies  >1 publications with GREM2 and Weight Loss
 Inflammation Antibodies  >1 publications with GREM2 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >29 publications with GREM2 and Bone
 Embryonic Tissue Antibodies  >9 publications with GREM2 and Embryonic Tissue
 Ovary Antibodies  >4 publications with GREM2 and Ovary
 Connective Tissue Antibodies  >3 publications with GREM2 and Connective Tissue
 Lung Antibodies  >2 publications with GREM2 and Lung
 Brain Antibodies  >2 publications with GREM2 and Brain
 Heart Antibodies  >1 publications with GREM2 and Heart
 Vascular Antibodies  >1 publications with GREM2 and Vascular
 Intestine Antibodies  >1 publications with GREM2 and Intestine
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