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| Product Name
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GREM2, Recombinant Protein
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| Also Known As
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GREM2, 22-168aa, Human, His tag, E Coli (Denatured)
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| Product Synonym Names
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Gremlin-2 precursor; Gremlin-2 precursor; CKTSF1B2; DAND3; PRDC
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| Sequence
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MGSSHHHHHH SSGLVPRGSH MGSRKNRPAG AIPSPYKDGS SNNSERWQHQ IKEVLASSQE ALVVTERKYL KSDWCKTQPL RQTVSEEGCR SRTILNRFCY GQCNSFYIPR HVKKEEESFQ SCAFCKPQRV TSVLVELECP GLDPPFRLKK IQKVKQCRCM SVNLSDSDKQ
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| OMIM
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AK024848 mRNA
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| 3D Structure
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ModBase 3D Structure for Q9H772
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| Host
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E Coli
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| Purity/Purification
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> 85% by SDS-PAGE
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| Form/Format
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Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.4M urea, 10% glycerol
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| Concentration
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1 mg/ml (determined by Bradford assay) (lot specific)
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| Antigen Species
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Human
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| Tag Information
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His-tag
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| Preparation and Storage
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Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
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| Other Notes
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Small volumes of GREM2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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GREM2 is a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this protein belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this protein may play a role in regulating organogenesis, body patterning, and tissue differentiation. Recombinant human GREM2 protein, fused to His-tag at N-terminus, was expressed in E Coli.
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| Product Categories/Family for GREM2 recombinant protein
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Signal Transduction
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| Applications Tested/Suitable for GREM2 recombinant protein
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SDS-PAGE
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| SDS-Page of GREM2 recombinant protein
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TOP
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| NCBI/Uniprot data below describe general gene information for GREM2. It may not necessarily be applicable to this product. |
| NCBI GI #
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71164892
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| NCBI GeneID
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64388
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| NCBI Accession #
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NP_071914
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_022469.3
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[Other Products]
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| UniProt Primary Accession #
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Q9H772
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[Other Products]
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| UniProt Secondary Accession #
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Q86UD9
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[Other Products]
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| UniProt Related Accession #
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Q9H772
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[Other Products]
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| Molecular Weight
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19 kDa (170aa)
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TOP
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| NCBI Official Full Name
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gremlin-2
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| NCBI Official Synonym Full Names
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gremlin 2, DAN family BMP antagonist
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| NCBI Official Symbol
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GREM2
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[Similar Products]
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| NCBI Official Synonym Symbols
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PRDC; DAND3; STHAG9; CKTSF1B2
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[Similar Products]
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| NCBI Protein Information
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gremlin-2
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| UniProt Protein Name
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Gremlin-2
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| UniProt Synonym Protein Names
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Cysteine knot superfamily 1, BMP antagonist 2; DAN domain family member 3; Protein related to DAN and cerberus
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| Protein Family
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Gremlin
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| UniProt Gene Name
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GREM2
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[Similar Products]
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| UniProt Synonym Gene Names
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CKTSF1B2; DAND3; PRDC
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[Similar Products]
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| NCBI Summary for GREM2
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This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq, Jul 2008]
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| UniProt Comments for GREM2
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Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells.
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TOP
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Sudo S, et al. (2004). J Biol Chem. 279 (22):23134-41.
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| Research Articles on GREM2
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1. Data show that the GREMLIN 2 (GREM2) expression during Induced Pluripotent Stem Cell (hiPS) cell cardiac differentiation follows the expression pattern of cardiac-specific genes.
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TOP
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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TOP
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| Products associated with GREM2 recombinant protein | Pathways associated with GREM2 recombinant protein |
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| Diseases associated with GREM2 recombinant protein | Organs/Tissues associated with GREM2 recombinant protein |
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TOP
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Recombinant Protein 
