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GRO a recombinant protein :: GRO-alpha Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143818 GRO a recombinant protein
Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $1,800 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GRO-alpha (GRO a), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human GRO-alpha (CXCL1), His Tag

 Product Synonym Names    GRO a Human, His; GRO-Alpha/MGSA Human Recombinant (CXCL1), His Tag; Growth-regulated protein alpha; CXCL1; Melanoma growth stimulatory activity; MGSA; Neutrophil-activating protein 3; NAP-3; GRO-alpha(1-73); chemokine (C-X-C motif) ligand 1; GRO1; GROa; SCYB1; MGSA-a; MGSA alpha; GRO a, His
 Product Gene Name   

GRO a recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MASVATELRC QCLQTLQGIH PKNIQSVNVK SPGPHCAQTE VIATLKNGRK ACLNPASPIV KKIIEKMLNS DKSN
 OMIM    155730
 3D Structure    ModBase 3D Structure for P09341
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 Host    E Coli
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 Purity/Purification    Greater than 90.0% as determined by SDS-PAGE.
 Form/Format    CXCL1 in 20mM Tris-HCL pH-8 and 10% glycerol.
Sterile Filtered colorless solution.
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 Preparation and Storage    Liquid CXCL1 although stable at 10 degree C for 1 week, should be stored below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of GRO a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for GRO a recombinant protein

   Description: CXCL1 Human Recombinant produced in E Coli is a single,non-glycosylated, polypeptide chain containing 94 amino acids (35-107) and having a molecular mass of 10.1 kDa. The CXCL1 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

Introduction: Chemokine (C-X-C motif) ligand 1 (CXCL1) is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-?). It is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. CXCL1 is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis. This chemokine elicits its effects by signaling through the chemokine receptor CXCR2. The gene for CXCL1 is located on human chromosome 4 amongst genes for other CXC chemokines.
 Product Categories/Family for GRO a recombinant protein    CHEMOKINES; Chemokines; GRO
NCBI/Uniprot data below describe general gene information for GRO a. It may not necessarily be applicable to this product.
 NCBI GI #    4504153
 NCBI GeneID    2919
 NCBI Accession #    NP_001502.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001511.3 [Other Products]
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 UniProt Primary Accession #    P09341 [Other Products]
 UniProt Secondary Accession #    Q9UCR7 [Other Products]
 UniProt Related Accession #    P09341 [Other Products]
 Molecular Weight    11,301 Da
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 NCBI Official Full Name    growth-regulated alpha protein
 NCBI Official Synonym Full Names    chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
 NCBI Official Symbol    CXCL1 [Similar Products]
 NCBI Official Synonym Symbols   
FSP; GRO1; GROa; MGSA; NAP-3; SCYB1; MGSA-a
[Similar Products]
 NCBI Protein Information    growth-regulated alpha protein; C-X-C motif chemokine 1; GRO-alpha(1-73); GRO1 oncogene (melanoma growth stimulating activity, alpha); GRO1 oncogene (melanoma growth-stimulating activity); MGSA alpha; fibroblast secretory protein; melanoma growth stimulatory activity alpha; neutrophil-activating protein 3
 UniProt Protein Name    Growth-regulated alpha protein
 UniProt Synonym Protein Names   
C-X-C motif chemokine 1; GRO-alpha(1-73); Melanoma growth stimulatory activity; MGSA; Neutrophil-activating protein 3; NAP-3
 UniProt Gene Name    CXCL1 [Similar Products]
 UniProt Synonym Gene Names    GRO; GRO1; GROA; MGSA; SCYB1; MGSA; NAP-3 [Similar Products]
 UniProt Entry Name    GROA_HUMAN
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 NCBI Summary for GRO a    This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014]
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 UniProt Comments for GRO a    CXCL1: Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function: growth factor activity; chemokine activity; CXCR chemokine receptor binding; enzyme activator activity; receptor binding

Biological Process: positive regulation of catalytic activity; nervous system development; negative regulation of cell proliferation; cell proliferation; G-protein coupled receptor protein signaling pathway; positive regulation of leukocyte chemotaxis; immune response; response to lipopolysaccharide; actin cytoskeleton organization and biogenesis; chemotaxis; signal transduction; inflammatory response
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 Research Articles on GRO a    1. The silencing of the pro-angiogenic chemokine GRO-alpha is proportionally correlated with decreased expression of CXCR2 in pro-inflammatory cytokine-stimulated SGEC indicating the GRO-alpha/CXCR2 complex as a novel therapeutic target for Sjogren's syndrome.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GRO a recombinant proteinPathways associated with GRO a recombinant protein
 Reference Product  PubMed Publications
 CXCL2 recombinant protein  >569 publications with GRO a and CXCL2
 CXCR2 recombinant protein  >330 publications with GRO a and CXCR2
 CCL5 recombinant protein  >257 publications with GRO a and CCL5
 CCL20 recombinant protein  >102 publications with GRO a and CCL20
 CXCL3 recombinant protein  >100 publications with GRO a and CXCL3
 CXCR1 recombinant protein  >98 publications with GRO a and CXCR1
 CXCL6 recombinant protein  >77 publications with GRO a and CXCL6
 IL6 recombinant protein  >69 publications with GRO a and IL6
 CXCL11 recombinant protein  >32 publications with GRO a and CXCL11
 DARC recombinant protein  >12 publications with GRO a and DARC
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response Pathway antibodies  Cytokines And Inflammatory Response Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Diseases associated with GRO a recombinant proteinOrgans/Tissues associated with GRO a recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1184 publications with GRO a and Inflammation
 Necrosis Antibodies  >568 publications with GRO a and Necrosis
 Disease Models, Animal Antibodies  >434 publications with GRO a and Disease Models, Animal
 Lung Diseases Antibodies  >337 publications with GRO a and Lung Diseases
 Cardiovascular Diseases Antibodies  >198 publications with GRO a and Cardiovascular Diseases
 Lung Injury Antibodies  >175 publications with GRO a and Lung Injury
 Pneumonia Antibodies  >116 publications with GRO a and Pneumonia
 Wounds and Injuries Antibodies  >98 publications with GRO a and Wounds and Injuries
 Reperfusion Injury Antibodies  >97 publications with GRO a and Reperfusion Injury
 Fibrosis Antibodies  >91 publications with GRO a and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1272 publications with GRO a and Blood
 Lung Antibodies  >511 publications with GRO a and Lung
 Vascular Antibodies  >372 publications with GRO a and Vascular
 Liver Antibodies  >187 publications with GRO a and Liver
 Skin Antibodies  >177 publications with GRO a and Skin
 Intestine Antibodies  >160 publications with GRO a and Intestine
 Heart Antibodies  >84 publications with GRO a and Heart
 Connective Tissue Antibodies  >65 publications with GRO a and Connective Tissue
 Uterus Antibodies  >26 publications with GRO a and Uterus
 Ascites Antibodies  >5 publications with GRO a and Ascites
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