NP_001503
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28.3kDa (246aa) confirmed by MALDI-TOF
NCBI Official Full Name
glutathione S-transferase A4
NCBI Official Synonym Full Names
glutathione S-transferase alpha 4
NCBI Protein Information
glutathione S-transferase A4
UniProt Protein Name
Glutathione S-transferase A4
UniProt Synonym Protein Names
GST class-alpha member 4; Glutathione S-transferase A4-4
NCBI Summary for GSTA4
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis. [provided by RefSeq, Jul 2008]
UniProt Comments for GSTA4
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE).
Product References and Citations for GSTA4 recombinant protein
Bruns C.M., et al. (1999) J. Mol. Biol. 288:427-439; Balogh L.M., et al. (2010) Biochemistry 49:1541-1548
Research Articles on GSTA4
Precautions
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Disclaimer
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Products associated with GSTA4 recombinant protein
Pathways associated with GSTA4 recombinant protein
Diseases associated with GSTA4 recombinant protein
Organs/Tissues associated with GSTA4 recombinant protein
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