NP_000839
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27.9 kDa (238aa), confirmed by MALDI-TOF
NCBI Official Full Name
glutathione S-transferase Mu 2 isoform 1
NCBI Official Synonym Full Names
glutathione S-transferase mu 2
NCBI Protein Information
glutathione S-transferase Mu 2
UniProt Protein Name
Glutathione S-transferase Mu 2
UniProt Synonym Protein Names
GST class-mu 2; GSTM2-2
UniProt Synonym Gene Names
NCBI Summary for GSTM2
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. [provided by RefSeq, Jul 2008]
UniProt Comments for GSTM2
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Product References and Citations for GSTM2 active protein
Hayes JD, et al. (1995) Crit Rev Biochem Mol Biol. 30 (6):445-600. ; Bogaards JJ, et al. (1992) Biochem J. 286:383-8.;
Research Articles on GSTM2
Precautions
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Disclaimer
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Products associated with GSTM2 active protein
Pathways associated with GSTM2 active protein
Diseases associated with GSTM2 active protein
Organs/Tissues associated with GSTM2 active protein
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