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SAR1A recombinant protein :: GTP-Binding Protein SAR1A Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143823 SAR1A recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GTP-Binding Protein SAR1A, Recombinant Protein

 Also Known As   

Recombinant Human GTP-Binding Protein SAR1A

 Product Synonym Names    SAR1A Human; GTP-Binding Protein SAR1A Human Recombinant; GTP-binding protein SAR1a; COPII-associated small GTPase; SAR1A; SAR1; SARA; SARA1
 Product Gene Name   

SAR1A recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MSFIFEWIYN GFSSVLQFLG LYKKSGKLVF LGLDNAGKTT LLHMLKDDRL GQHVPTLHPT SEELTIAGMT FTTFDLGGHE QARRVWKNYL PAINGIVFLV DCADHSRLVE SKVELNALMT DETISNVPIL ILGNKIDRTD AISEEKLREI FGLYGQTTGK GNVTLKELNA RPMEVFMCSV LKRQGYGEGF RWLSQYID
 OMIM    607691
 3D Structure    ModBase 3D Structure for Q9NR31
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 Host    E Coli
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 Purity/Purification    Greater than 90.0% as determined by SDS-PAGE.
 Form/Format    The SAR1A solution contains 20mM Tris-HCl buffer (pH8.0), 1mM DTT and 10% glycerol.
Sterile Filtered colorless solution.
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 Preparation and Storage    SAR1A although stable 4 degree C for 4 weeks, should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of SAR1A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SAR1A recombinant protein

   Description: SAR1A Human Recombinant fused with 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 218 amino acids (1- 198 a.a.) and having a molecular mass of 24.5kDa.The SAR1A is purified by proprietary chromatographic techniques.

Introduction: SAR1A is a member of the small GTPase superfamily. SAR1A is a vital component of COPII vesicle coats involved in export of cargo from the ER (Endoplasmic Reticulum). The GTPase activity of SAR1A serves as a molecular switch to control protein-protein and protein-lipid interactions which dictate vesicle budding from the ER. SAR1A, while GDP-bound interacts with the membrane-bound exchange factor Sec12 and trades its bound GDP for GTP. SAR1A is also involved in the transport from the ER to the Golgi apparatus. SAR1A is required to maintain SEC16A localization at distinct locations on the ER membrane possibly by preventing its dissociation. SAR1A-GTP-dependent compilation of SEC16A on the ER membrane creates a structured scaffold defining endoplasmic reticulum exit sites.
 Product Categories/Family for SAR1A recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
NCBI/Uniprot data below describe general gene information for SAR1A. It may not necessarily be applicable to this product.
 NCBI GI #    217416369
 NCBI GeneID    56681
 NCBI Accession #    NP_001136120.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001142648.1 [Other Products]
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 UniProt Primary Accession #    Q9NR31 [Other Products]
 UniProt Secondary Accession #    B4DQ19 [Other Products]
 UniProt Related Accession #    Q9NR31 [Other Products]
 Molecular Weight    17,500 Da
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 NCBI Official Full Name    GTP-binding protein SAR1a
 NCBI Official Synonym Full Names    secretion associated, Ras related GTPase 1A
 NCBI Official Symbol    SAR1A [Similar Products]
 NCBI Official Synonym Symbols   
SAR1; Sara; SARA1; masra2
[Similar Products]
 NCBI Protein Information    GTP-binding protein SAR1a; COPII-associated small GTPase; SAR1 gene homolog A; SAR1 homolog A; SAR1a gene homolog 1
 UniProt Protein Name    GTP-binding protein SAR1a
 UniProt Synonym Protein Names   
COPII-associated small GTPase
 Protein Family    GTP-binding protein
 UniProt Gene Name    SAR1A [Similar Products]
 UniProt Synonym Gene Names    SAR1; SARA; SARA1 [Similar Products]
 UniProt Entry Name    SAR1A_HUMAN
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 UniProt Comments for SAR1A    SAR1A: Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES). Belongs to the small GTPase superfamily. SAR1 family.

Protein type: G protein, monomeric; G protein, monomeric, SAR1; G protein

Chromosomal Location of Human Ortholog: 10q22.1

Cellular Component: Golgi apparatus; sarcoplasmic reticulum

Molecular Function: GTP binding

Biological Process: vesicle-mediated transport; intracellular protein transport
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 Research Articles on SAR1A    1. although Sar1A antagonizes the lipoprotein secretion-promoting activity of Sar1B, both isoforms modulate the expression of genes encoding cholesterol biosynthetic enzymes and the synthesis of cholesterol de novo.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SAR1A recombinant proteinPathways associated with SAR1A recombinant protein
 Reference Product  PubMed Publications
 SEC13 recombinant protein  >6 publications with SAR1A and SEC13
 SEC31A recombinant protein  >5 publications with SAR1A and SEC31A
 CDC42 recombinant protein  >1 publications with SAR1A and CDC42
 PREB recombinant protein  >1 publications with SAR1A and PREB
 Products by Pathway  Pathway Diagram
 COPII Complex Pathway antibodies  COPII Complex Pathway Diagram
 COPII Complex Pathway antibodies  COPII Complex Pathway Diagram
 Legionellosis Pathway antibodies  Legionellosis Pathway Diagram
 Legionellosis Pathway antibodies  Legionellosis Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 SREBP Signalling Pathway antibodies  SREBP Signalling Pathway Diagram
Diseases associated with SAR1A recombinant proteinOrgans/Tissues associated with SAR1A recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with SAR1A and Nervous System Diseases
 Musculoskeletal Diseases Antibodies  >2 publications with SAR1A and Musculoskeletal Diseases
 Brain Diseases Antibodies  >1 publications with SAR1A and Brain Diseases
 Heart Diseases Antibodies  >1 publications with SAR1A and Heart Diseases
 Fibrosis Antibodies  >1 publications with SAR1A and Fibrosis
 Anemia, Hemolytic Antibodies  >1 publications with SAR1A and Anemia, Hemolytic
 Anemia Antibodies  >1 publications with SAR1A and Anemia
 Organ/Tissue Name  Pubmed Publications
 Pituitary Gland Antibodies  >4 publications with SAR1A and Pituitary Gland
 Brain Antibodies  >4 publications with SAR1A and Brain
 Heart Antibodies  >2 publications with SAR1A and Heart
 Kidney Antibodies  >2 publications with SAR1A and Kidney
 Blood Antibodies  >2 publications with SAR1A and Blood
 Liver Antibodies  >1 publications with SAR1A and Liver
 Vascular Antibodies  >1 publications with SAR1A and Vascular
 Intestine Antibodies  >1 publications with SAR1A and Intestine
 Pancreas Antibodies  >1 publications with SAR1A and Pancreas
 Bone Antibodies  >1 publications with SAR1A and Bone
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