NP_001258922.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
39,243 Da
NCBI Official Full Name
galactoside 2-alpha-L-fucosyltransferase 2
NCBI Official Synonym Full Names
fucosyltransferase 2
NCBI Protein Information
galactoside 2-alpha-L-fucosyltransferase 2
UniProt Protein Name
Galactoside 2-alpha-L-fucosyltransferase 2
UniProt Synonym Protein Names
Alpha(1,2)FT 2; Fucosyltransferase 2; GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2; Secretory blood group protein 2
UniProt Synonym Gene Names
NCBI Summary for Fut2
This gene is one of three genes in mouse which encode a galactoside 2-L-fucosyltransferase. These genes differ in their developmental- and tissue-specific expression. The encoded type II membrane protein is anchored in the Golgi apparatus and controls the final step in the creation of alpha (1,2) fucosylated carbhohydrates by the addition of a terminal fucose in an alpha (1,2) linkage. This enzyme is involved in the synthesis of the Lewis antigen as well as the H-antigen, a precursor of the A and B antigens of the ABH histo-blood group. The biological function of the fucosylated carbhohydrate products is thought to involve cell-adhesion and interactions with microorganisms. Disruption of this gene results in altered glycosylation of gastric mucosa and uterine epithelia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
UniProt Comments for Fut2
Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids (PubMed:11323419, PubMed:27161092). The resulting epitope plays a role in cell-cell interaction including host-microbe interaction (PubMed:19706747, PubMed:27161092). Mediates interaction with intestinal microbiota influencing its composition (PubMed:19706747, PubMed:27161092). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen, which is an essential substrate for the final step in the blood group antigen synthesis pathway (PubMed:11323419).
Research Articles on Fut2
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Products associated with Fut2 recombinant protein
Pathways associated with Fut2 recombinant protein
Diseases associated with Fut2 recombinant protein
Organs/Tissues associated with Fut2 recombinant protein
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