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LGALS1 recombinant protein :: Galectin-1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS691972 LGALS1 recombinant protein
Unit / Price
0.01 mg  /  $215 +1 FREE 8GB USB
0.05 mg  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Galectin-1 (LGALS1), Recombinant Protein

★Popular Item★
 Also Known As   

Human Galectin-1

 Product Synonym Names    Recombinant Human Galectin-1
 Product Gene Name   

LGALS1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    ACGLVASNLN LKPGECLRVR GEVAPDAKSF VLNLGKDSNN LCLHFNPRFN AHGDANTIVC NSKDGGAWGT EQREAVFPFQ PGSVAEVCIT FDQANLTVKL PDGYEFKFPN RLNLEAINYM AADGDFKIKC VAFD
 Chromosome Location    Chromosome: 22; NC_000022.11 (37675606..37679802). Location: 22q13.1
 OMIM    150570
 3D Structure    ModBase 3D Structure for P09382
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 Host    E Coli
 Species Reactivity    Human
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 Purity/Purification    > 98% by SDS-PAGE and HPLC analyses
 Form/Format    Lyophilized
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 Endotoxin Level    < 0.1 ng/ug of protein (<1EU/ug).
 Biological Activity    Determined by its ability to chemoattract human blood monocytes. Chemotactic activity was observed at a concentration of 2.5 ug/ml with a peak response obtained at 250 ug/ml.
 Reconstitution    Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0mg/m. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at-20 to -80 degree C.
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 Preparation and Storage    Thy lyophilized protein is stable at room temperature for 1 month and at 4 degree C for 6 months. Reconstituted working aliquots are stable for 1 week at 2-8 degree C and for 3 months at -20 degree to -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of LGALS1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for LGALS1 recombinant protein

   Lectins, of either plant or animal origin, are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. The Galectins are lectins that recognize and interact with beta-galactoside moieties. Galectin-1 is an animal lectin that has been shown to interact with CD3, CD4, and CD45. It induces apoptosis of activated T-cells and T-leukemia cell lines and inhibits the protein phosphatase activity of CD45. Recombinant human Galectin-1 is a 14.5 kDa protein containing 134 amino acid residues.
 Product Categories/Family for LGALS1 recombinant protein    Cytokines & Growth Factors
NCBI/Uniprot data below describe general gene information for LGALS1. It may not necessarily be applicable to this product.
 NCBI GI #    4504981
 NCBI GeneID    3956
 NCBI Accession #    NP_002296.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002305.3 [Other Products]
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 UniProt Primary Accession #    P09382 [Other Products]
 UniProt Secondary Accession #    Q9UDK5; B2R5E8 [Other Products]
 UniProt Related Accession #    P09382 [Other Products]
 Molecular Weight    14.5 kDa [Similar Products]
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 NCBI Official Full Name    galectin-1
 NCBI Official Synonym Full Names    lectin, galactoside-binding, soluble, 1
 NCBI Official Symbol    LGALS1 [Similar Products]
 NCBI Official Synonym Symbols   
GBP; GAL1
[Similar Products]
 NCBI Protein Information    galectin-1; HBL; HPL; gal-1; HLBP14; galaptin; galectin 1; 14 kDa lectin; S-Lac lectin 1; lactose-binding lectin 1; 14 kDa laminin-binding protein; putative MAPK-activating protein PM12; beta-galactoside-binding lectin L-14-I; beta-galactoside-binding protein 14kDa
 UniProt Protein Name    Galectin-1
 UniProt Synonym Protein Names   
14 kDa laminin-binding protein; HLBP14; 14 kDa lectin; Beta-galactoside-binding lectin L-14-I; Galaptin; HBL; HPL; Lactose-binding lectin 1; Lectin galactoside-binding soluble 1; Putative MAPK-activating protein PM12; S-Lac lectin 1
 Protein Family    Galectin
 UniProt Gene Name    LGALS1 [Similar Products]
 UniProt Synonym Gene Names    Gal-1; HLBP14 [Similar Products]
 UniProt Entry Name    LEG1_HUMAN
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 NCBI Summary for LGALS1    The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for LGALS1    Function: May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Ref.24 Ref.26 Ref.31

Subunit structure: Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD7, CD43 and CD45. Interacts with laminin (via poly-N-acetyllactosamine). Ref.18 Ref.23 Ref.30 Ref.31

Subcellular location: Secreted › extracellular space › extracellular matrix Ref.24.

Tissue specificity: Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells. Ref.4 Ref.26

Sequence similarities: Contains 1 galectin domain.
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 Research Articles on LGALS1    1. Gal-1 as a diagnostic biomarker and immunotherapeutic target for LSCC.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LGALS1 recombinant proteinPathways associated with LGALS1 recombinant protein
 Reference Product  PubMed Publications
 PTPRC recombinant protein  >31 publications with LGALS1 and PTPRC
 CD7 recombinant protein  >20 publications with LGALS1 and CD7
 MYC recombinant protein  >10 publications with LGALS1 and MYC
 TDG recombinant protein  >6 publications with LGALS1 and TDG
 GEMIN4 recombinant protein  >4 publications with LGALS1 and GEMIN4
 MAX recombinant protein  >2 publications with LGALS1 and MAX
 BEX2 recombinant protein  >1 publications with LGALS1 and BEX2
 POU2AF1 recombinant protein  >1 publications with LGALS1 and POU2AF1
 Products by Pathway  Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Repression Pathway antibodies  Validated Targets Of C-MYC Transcriptional Repression Pathway Diagram
Diseases associated with LGALS1 recombinant proteinOrgans/Tissues associated with LGALS1 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >351 publications with LGALS1 and Neoplasms
 Inflammation Antibodies  >110 publications with LGALS1 and Inflammation
 Disease Models, Animal Antibodies  >65 publications with LGALS1 and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >64 publications with LGALS1 and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >57 publications with LGALS1 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >46 publications with LGALS1 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >37 publications with LGALS1 and Breast Neoplasms
 Lung Diseases Antibodies  >29 publications with LGALS1 and Lung Diseases
 Lung Neoplasms Antibodies  >29 publications with LGALS1 and Lung Neoplasms
 Necrosis Antibodies  >27 publications with LGALS1 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >336 publications with LGALS1 and Blood
 Brain Antibodies  >85 publications with LGALS1 and Brain
 Vascular Antibodies  >68 publications with LGALS1 and Vascular
 Muscle Antibodies  >59 publications with LGALS1 and Muscle
 Nerve Antibodies  >56 publications with LGALS1 and Nerve
 Bone Antibodies  >50 publications with LGALS1 and Bone
 Lung Antibodies  >48 publications with LGALS1 and Lung
 Skin Antibodies  >47 publications with LGALS1 and Skin
 Embryonic Tissue Antibodies  >45 publications with LGALS1 and Embryonic Tissue
 Liver Antibodies  >44 publications with LGALS1 and Liver
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