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LGALS3 recombinant protein :: Galectin-3 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS691554 LGALS3 recombinant protein
Unit / Price
0.01 mg  /  $215 +1 FREE 8GB USB
0.05 mg  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Galectin-3 (LGALS3), Recombinant Protein

★Popular Item★
 Also Known As   

Human Galectin-3

 Product Synonym Names    Recombinant Human Galectin-3
 Product Gene Name   

LGALS3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    ADNFSLHDAL SGSGNPNPQG WPGAWGNQPA GAGGYPGASY PGAYPG QAPP GAYPGQAPPG AYHGAPGAYP GAPAPGVYPG PPSGPGAYPS S GQPSAPGAY PATGPYGAPA GPLIVPYNLP LPGGVVPRML ITILGTV KPN ANRIALDFQR GNDVAFHFNP RFNENNRRVI VCNTKLDNNW GR EERQSVFP FESGKPFKIQ VLVEPDHFKV AVNDAHLLQY NHRVKKLN EI SKLGISGDID LTSASYTMI
 Chromosome Location    Chromosome: 14; NC_000014.9 (55129217..55145430). Location: 14q22.3
 OMIM    153619
 3D Structure    ModBase 3D Structure for P17931
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 Host    E Coli
 Species Reactivity    Human
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 Purity/Purification    > 98% by SDS-PAGE and HPLC analysis
 Form/Format    Lyophilized from 0.5x PBS, pH 7.2
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 Endotoxin Level    < 0.1 ng per ug of Galectin-3
 Biological Activity    Determined by its ability to chemoattract human blood monocytes. Chemotactic activity was observed at a concentration of 2.5 ug/ml with a peak response obtained at 250 ug/ml.
 Reconstitution    The human Galectin-3 should be reconstituted in water to a concentration of 0.1-1.0 mg/ml. Do not vortex! This solution can be diluted in water or other buffer solutions or stored at -20 degree C.
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 Preparation and Storage    The lyophilized protein is stable for a 1 month at room temperature or 6 months at 4 degree C. The reconstituted protein is stable for 1 week at 2 degree C to 8 degree C and 3 months at -20 degreeC to 8 degree c and 3 months at -20 degree C to -80 degree C. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (e.g. 0.1% BSA) and store in working aliquots at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of LGALS3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for LGALS3 recombinant protein

   Lectins, of either plant or animal origin, are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. The Galectins are lectins that recognize and interact with beta-galactoside moieties. Galectin-3 regulates a number of biological processes, including embryogenesis, inflammatory responses, cell progression and metastasis. Galectin-3 is normally expressed in epithelia of a variety of tissues, including colon and endometrium, and in various inflammatory cells, including macrophages. Galectin-3 can function intracellularly, in controlling cell cycle and preventing T-cell apoptosis, and also extracellularly, in activating various cells, including monocytes/macrophages, mast cells, neutrophils, and lymphocytes. Expression of Galectin-3 is affected by neoplastic transformation, being up-regulated in certain types of lymphomas, and in thyroid and hepatic carcinomas. Conversely, it is down-regulated in other cancers, such as colon, breast, ovarian, and uterine. Recombinant human Galectin-3 is a globular 26.0 kDa protein containing 250 amino acid residues, but no disulfide bonds.
 Product Categories/Family for LGALS3 recombinant protein    Cytokines & Growth Factors
NCBI/Uniprot data below describe general gene information for LGALS3. It may not necessarily be applicable to this product.
 NCBI GI #    115430223
 NCBI GeneID    3958
 NCBI Accession #    NP_002297.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002306.3 [Other Products]
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 UniProt Primary Accession #    P17931 [Other Products]
 UniProt Secondary Accession #    Q16005; Q6IBA7; Q96J47; B2RC38 [Other Products]
 UniProt Related Accession #    P17931 [Other Products]
 Molecular Weight    26.0 kDa [Similar Products]
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 NCBI Official Full Name    galectin-3 isoform 1
 NCBI Official Synonym Full Names    lectin, galactoside-binding, soluble, 3
 NCBI Official Symbol    LGALS3 [Similar Products]
 NCBI Official Synonym Symbols   
L31; GAL3; MAC2; CBP35; GALBP; GALIG; LGALS2
[Similar Products]
 NCBI Protein Information    galectin-3; lectin L-29; 35 kDa lectin; MAC-2 antigen; IgE-binding protein; laminin-binding protein; galactose-specific lectin 3; carbohydrate-binding protein 35
 UniProt Protein Name    Galectin-3
 UniProt Synonym Protein Names   
35 kDa lectin; Carbohydrate-binding protein 35; CBP 35; Galactose-specific lectin 3; Galactoside-binding protein; GALBP; IgE-binding protein; L-31; Laminin-binding protein; Lectin L-29; Mac-2 antigen
 Protein Family    Galectin
 UniProt Gene Name    LGALS3 [Similar Products]
 UniProt Synonym Gene Names    MAC2; Gal-3; CBP 35; GALBP [Similar Products]
 UniProt Entry Name    LEG3_HUMAN
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 NCBI Summary for LGALS3    This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
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 UniProt Comments for LGALS3    Function: Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis

By similarity. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Ref.15 Ref.16 Ref.18

Subunit structure: Probably forms homo- or heterodimers. Interacts with DMBT1

By similarity. Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA. Ref.14 Ref.15

Subcellular location: Cytoplasm. Nucleus. Secreted. Note: Secreted by a non-classical secretory pathway and associates with the cell surface. Ref.5 Ref.15 Ref.18

Tissue specificity: A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes. Ref.17

Sequence similarities: Contains 1 galectin domain.
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 Research Articles on LGALS3    1. These data indicate that galectin-3 plays an important role in a murine model of disseminated candidiasis and suggest a potential mechanism of neonatal susceptibility to these infections.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LGALS3 recombinant proteinPathways associated with LGALS3 recombinant protein
 Reference Product  PubMed Publications
 LGALS3BP recombinant protein  >36 publications with LGALS3 and LGALS3BP
 EGFR recombinant protein  >27 publications with LGALS3 and EGFR
 MUC1 recombinant protein  >22 publications with LGALS3 and MUC1
 KRAS recombinant protein  >9 publications with LGALS3 and KRAS
 GEMIN4 recombinant protein  >5 publications with LGALS3 and GEMIN4
 PRKCSH recombinant protein  >2 publications with LGALS3 and PRKCSH
 NRAS recombinant protein  >2 publications with LGALS3 and NRAS
 HRAS recombinant protein  >2 publications with LGALS3 and HRAS
 DDOST recombinant protein  >2 publications with LGALS3 and DDOST
 SUFU recombinant protein  >1 publications with LGALS3 and SUFU
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Advanced Glycosylation Endproduct Receptor Signaling Pathway antibodies  Advanced Glycosylation Endproduct Receptor Signaling Pathway Diagram
 Hedgehog Signaling Events Mediated By Gli Proteins Pathway antibodies  Hedgehog Signaling Events Mediated By Gli Proteins Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
Diseases associated with LGALS3 recombinant proteinOrgans/Tissues associated with LGALS3 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >835 publications with LGALS3 and Neoplasms
 Carcinoma Antibodies  >500 publications with LGALS3 and Carcinoma
 Inflammation Antibodies  >225 publications with LGALS3 and Inflammation
 Adenocarcinoma Antibodies  >217 publications with LGALS3 and Adenocarcinoma
 Neoplasm Metastasis Antibodies  >138 publications with LGALS3 and Neoplasm Metastasis
 Adenoma Antibodies  >134 publications with LGALS3 and Adenoma
 Disease Models, Animal Antibodies  >131 publications with LGALS3 and Disease Models, Animal
 Nervous System Diseases Antibodies  >127 publications with LGALS3 and Nervous System Diseases
 Fibrosis Antibodies  >111 publications with LGALS3 and Fibrosis
 Breast Neoplasms Antibodies  >106 publications with LGALS3 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >507 publications with LGALS3 and Blood
 Thyroid Antibodies  >277 publications with LGALS3 and Thyroid
 Vascular Antibodies  >148 publications with LGALS3 and Vascular
 Heart Antibodies  >130 publications with LGALS3 and Heart
 Brain Antibodies  >124 publications with LGALS3 and Brain
 Liver Antibodies  >107 publications with LGALS3 and Liver
 Kidney Antibodies  >105 publications with LGALS3 and Kidney
 Bone Antibodies  >105 publications with LGALS3 and Bone
 Lung Antibodies  >105 publications with LGALS3 and Lung
 Muscle Antibodies  >80 publications with LGALS3 and Muscle
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