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LGALS4 recombinant protein :: Galectin-4 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143568 LGALS4 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,235 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Galectin-4 (LGALS4), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Galectin-4

 Product Synonym Names    LGALS4 Human; Galectin-4 Human Recombinant; Galectin-4; Gal-4; Lactose-binding lectin 4; L-36 lactose-binding protein; L36LBP; Antigen NY-CO-27; LGALS4; lectin galactoside-binding soluble 4; GAL4
 Product Gene Name   

LGALS4 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MAYVPAPGYQ PTYNPTLPYY QPIPGGLNVG MSVYIQGVAS EHMKRFFVNF VVGQDPGSDV AFHFNPRFDG WDKVVFNTLQ GGKWGSEERK RSMPFKKGAA FELVFIVLAE HYKVVVNGNP FYEYGHRLPL QMVTHLQVDG DLQLQSINFI GGQPLRPQGP PMMPPYPGPG HCHQQLNSLP TMEGPPTFNP PVPYFGRLQG GLTARRTIII KGYVPPTGKS FAINFKVGSS GDIALHINPR MGNGTVVRNS LLNGSWGSEE KKITHNPFGP GQFFDLSIRC GLDRFKVYAN GQHLFDFAHR LSAFQRVDTL EIQGDVTLSY VQI
 OMIM    602518
 3D Structure    ModBase 3D Structure for P56470
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    The LGALS4 protein solution contains 20mM Tris-HCl, pH-8, 1mM DTT and 10% glycerol.
Sterile filtered colorless solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of LGALS4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for LGALS4 recombinant protein

   Description: Galectin-4 produced in E Coli is a single, non-glycosylated polypeptide chain containing 343 amino acids (1-323 a.a.) and having a molecular mass of 38.1kDa.Galectin-4 is fused to 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

Introduction: Galectin-4 is a member of the subfamily of galectins composed of two carbohydrate recognition domains having similar peptide chains. The galectins are a family of beta-galactoside-binding proteins having a role in modulating cell-cell and cell-matrix interactions, which inhibits chronic inflammations, GVHD, and allergic responses. LGALS4 expression is limited to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer. LGALS4 binds as an endogenous ligand to glycosphingolipids having 3-O-sulfated Gal residues and bind as well to cholesterol-3-sulfate. LGALS4 takes part in cell adhesion. LGALS4 plays a role in crosslinking the lateral cell membranes of the surface-lining epithelial cells, thus supporting epithelial integrity against mechanical stress exerted by the bowel lume. LGALS4 is in charge of intestinal inflammation via selective regulation of peripheral and mucosal T-cell cell cycle, in addition to cell death by apoptosis of T-cells by a pathway independent of the activation of caspases. LGALS4 blockade decreases TNF-alpha inhibitor induced T-cell death. LGALS4 decreases pro-inflammatory cytokine secretion including IL-6 & IL-17.
 Product Categories/Family for LGALS4 recombinant protein    CYTOKINES AND GROWTH FACTORS; Growth Factors; Galectin
NCBI/Uniprot data below describe general gene information for LGALS4. It may not necessarily be applicable to this product.
 NCBI GI #    5453712
 NCBI GeneID    3960
 NCBI Accession #    NP_006140.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006149.3 [Other Products]
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 UniProt Primary Accession #    P56470 [Other Products]
 UniProt Related Accession #    P56470 [Other Products]
 Molecular Weight    35,941 Da
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 NCBI Official Full Name    galectin-4
 NCBI Official Synonym Full Names    lectin, galactoside-binding, soluble, 4
 NCBI Official Symbol    LGALS4 [Similar Products]
 NCBI Official Synonym Symbols   
GAL4; L36LBP
[Similar Products]
 NCBI Protein Information    galectin-4; L-36 lactose-binding protein; antigen NY-CO-27; gal-4; galectin 4; lactose-binding lectin 4
 UniProt Protein Name    Galectin-4
 UniProt Synonym Protein Names   
Antigen NY-CO-27; L-36 lactose-binding protein; L36LBP; Lactose-binding lectin 4
 Protein Family    Galectin
 UniProt Gene Name    LGALS4 [Similar Products]
 UniProt Synonym Gene Names    Gal-4; L36LBP [Similar Products]
 UniProt Entry Name    LEG4_HUMAN
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 NCBI Summary for LGALS4    The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The expression of this gene is restricted to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer. [provided by RefSeq, Jul 2008]
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 UniProt Comments for LGALS4    galectin-4: Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: plasma membrane; cytosol

Molecular Function: carbohydrate binding

Biological Process: cell adhesion
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 Research Articles on LGALS4    1. The results show galectin-4 expression closely associates with hepatocellular carcinoma (HCC) progression and might have potential use as a prognostic biomarker for HCC patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LGALS4 recombinant proteinDiseases associated with LGALS4 recombinant protein
 Reference Product  PubMed Publications
 CCNB1 recombinant protein  >1 publications with LGALS4 and CCNB1
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >30 publications with LGALS4 and Carcinoma
 Adenocarcinoma Antibodies  >20 publications with LGALS4 and Adenocarcinoma
 Inflammation Antibodies  >12 publications with LGALS4 and Inflammation
 Neoplasm Metastasis Antibodies  >10 publications with LGALS4 and Neoplasm Metastasis
 Lung Neoplasms Antibodies  >8 publications with LGALS4 and Lung Neoplasms
 Liver Diseases Antibodies  >6 publications with LGALS4 and Liver Diseases
 Liver Neoplasms Antibodies  >6 publications with LGALS4 and Liver Neoplasms
 Brain Diseases Antibodies  >5 publications with LGALS4 and Brain Diseases
 Cell Transformation, Neoplastic Antibodies  >4 publications with LGALS4 and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >4 publications with LGALS4 and Neoplasms, Experimental
Organs/Tissues associated with LGALS4 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >40 publications with LGALS4 and Intestine
 Blood Antibodies  >30 publications with LGALS4 and Blood
 Liver Antibodies  >19 publications with LGALS4 and Liver
 Stomach Antibodies  >17 publications with LGALS4 and Stomach
 Kidney Antibodies  >10 publications with LGALS4 and Kidney
 Brain Antibodies  >10 publications with LGALS4 and Brain
 Lung Antibodies  >10 publications with LGALS4 and Lung
 Embryonic Tissue Antibodies  >6 publications with LGALS4 and Embryonic Tissue
 Bladder Antibodies  >4 publications with LGALS4 and Bladder
 Pancreas Antibodies  >3 publications with LGALS4 and Pancreas
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