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GABRB2 recombinant protein :: Gamma-aminobutyric acid receptor subunit beta-2 (GABRB2) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS953526 GABRB2 recombinant protein
Unit / Price
1 mg (E-Coli)  /  $1,375 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,835 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Gamma-aminobutyric acid receptor subunit beta-2 (GABRB2), Recombinant Protein

 Also Known As   

Recombinant Human Gamma-aminobutyric acid receptor subunit beta-2 (GABRB2)

 Product Synonym Names    Recombinant Gamma-aminobutyric acid receptor subunit beta-2 (GABRB2); Gamma-aminobutyric acid receptor subunit beta-2; GABA(A) receptor subunit beta-2
 Product Gene Name   

GABRB2 recombinant protein

[Similar Products]
 Product Synonym Gene Name    GABRB2 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    26-244
 Sequence    SVNDPSNMSL VKETVDRLLK GYDIRLRPDF GGPPVAVGMN IDIASIDMVS EVNMDYTLTM YFQQAWRDKR LSYNVIPLNL TLDNRVADQL WVPDTYFLND KKSFVHGVTV KNRMIRLHPD GTVLYGLRIT TTAACMMDLR RYPLDEQNCT LEIESYGYTT DDIEFYWRGD DNAVTGVTKI ELPQFSIVDY KLITKKVVFS TGSYPRLSLS FKLKRNIGY
 Chromosome Location    Chromosome: 5; NC_000005.9 (160715436..160975130, complement). Location: 5q34
 OMIM    600232
 3D Structure    ModBase 3D Structure for P47870
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of GABRB2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for GABRB2. It may not necessarily be applicable to this product.
 NCBI GI #    4503865
 NCBI GeneID    2561
 NCBI Accession #    NP_000804.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000813.2 [Other Products]
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 UniProt Primary Accession #    P47870 [Other Products]
 UniProt Secondary Accession #    Q16323; Q4FZB2; A8K115; A8K1A0; D1LYT0; D1LYT1 [Other Products]
 UniProt Related Accession #    P47870 [Other Products]
 Molecular Weight    59,150 Da [Similar Products]
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 NCBI Official Full Name    gamma-aminobutyric acid receptor subunit beta-2 isoform 2
 NCBI Official Synonym Full Names    gamma-aminobutyric acid (GABA) A receptor, beta 2
 NCBI Official Symbol    GABRB2 [Similar Products]
 NCBI Protein Information    gamma-aminobutyric acid receptor subunit beta-2; GABA(A) receptor, beta 2; GABA(A) receptor subunit beta-2; gamma-aminobutyric acid A receptor beta 2
 UniProt Protein Name    Gamma-aminobutyric acid receptor subunit beta-2
 UniProt Synonym Protein Names   
GABA(A) receptor subunit beta-2
 Protein Family    Gamma-aminobutyric acid receptor
 UniProt Gene Name    GABRB2 [Similar Products]
 UniProt Entry Name    GBRB2_HUMAN
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 NCBI Summary for GABRB2    The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GABRB2    Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Subunit structure: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1. Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents

By similarity.

Subcellular location: Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Tissue specificity: Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression. Ref.3 Ref.7

Sequence similarities: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB2 sub-subfamily. [View classification]
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 Research Articles on GABRB2    1. GABRA receptor beta2 subunit is not involved in amygdala hyperexcitability of patients with temporal lobe epilepsy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with GABRB2 recombinant proteinDiseases associated with GABRB2 recombinant protein
 Products by Pathway  Pathway Diagram
 GABA A Receptor Activation Pathway antibodies  GABA A Receptor Activation Pathway Diagram
 GABA Receptor Activation Pathway antibodies  GABA Receptor Activation Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Ligand-gated Ion Channel Transport Pathway antibodies  Ligand-gated Ion Channel Transport Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >33 publications with GABRB2 and Mental Disorders
 Schizophrenia Antibodies  >23 publications with GABRB2 and Schizophrenia
 Nervous System Diseases Antibodies  >12 publications with GABRB2 and Nervous System Diseases
 Central Nervous System Diseases Antibodies  >12 publications with GABRB2 and Central Nervous System Diseases
 Brain Diseases Antibodies  >10 publications with GABRB2 and Brain Diseases
 Seizures Antibodies  >10 publications with GABRB2 and Seizures
 Epilepsy Antibodies  >9 publications with GABRB2 and Epilepsy
 Substance-Related Disorders Antibodies  >8 publications with GABRB2 and Substance-Related Disorders
 Bipolar Disorder Antibodies  >6 publications with GABRB2 and Bipolar Disorder
 Mood Disorders Antibodies  >5 publications with GABRB2 and Mood Disorders
Organs/Tissues associated with GABRB2 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >42 publications with GABRB2 and Brain
 Kidney Antibodies  >11 publications with GABRB2 and Kidney
 Muscle Antibodies  >2 publications with GABRB2 and Muscle
 Eye Antibodies  >2 publications with GABRB2 and Eye
 Intestine Antibodies  >2 publications with GABRB2 and Intestine
 Blood Antibodies  >1 publications with GABRB2 and Blood
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